Sentences with phrase «uncertainty of the future state»

This sounds like a prudent practice to account for the uncertainty of the future state of the market, however, such an assumption may not reflect the true path of cap rates over the investment holding period.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

With mounting uncertainty over Qatar's near - to - midterm future as a growing LNG supplier amid fissures in the Gulf Cooperation Council, Europe should capitalize on the emergence of the United States as an energy exporter.

As the Climate Science Special Report states, the magnitude of future climate change depends significantly on «remaining uncertainty in the sensitivity of Earth's climate to [greenhouse gas] emissions,»» White House spokesperson Raj Shah said Friday in a statement.

Given the recent political turmoil in the United States, there has been a great deal of uncertainty regarding Canada's future dealings with its biggest trade partner.

With mounting uncertainty over the future of the North American free - trade agreement and more states eyeing possible Buy American rules, Ontario is keeping the policy ready in case it is needed, a senior government official told The Globe and Mail.

Even just uncertainty over future tax hikes can be enough to drive investment out of the state toward a more investment - friendly, fiscally sound climate.

Barring any unexpected breakthrough, the future of the United States» trade relationship with Mexico and Canada will likely remain in a state of uncertainty indefinitely.

She has lived in a perpetual state of uncertainty about what future she has in the UK ever since the Home Office rejected her application for asylum.

Sigurdsson did not travel with the rest of the Swansea team for their pre-season tour of the United States, with a club statement explaining that the midfielder «did not feel in the right frame of mind to travel due to the current uncertainty over his future».

The problem with making satisfying interactions the main criteria of marital success is that it plunges partners into a permanent state of uncertainty about the future of the relationship, undermining the very good & 8212; both emotional and practical security & 8212; that moves men and women toward marriage.

New York is short $ 4.4 billion, and there's uncertainty over federal policies, including the overhaul of the tax code, that could leave the state with even a bigger budget hole in the future.

The Electoral Commission of Ghana over 5 months period has walked this Nation along a volatile path of uncertainty over what the future state of the voters» register is.

«The state continues to contemplate putting the district under increased state oversight, but uncertainty remains regarding the state's future level of involvement in the district's operations.»

The battle for increased reimbursement will play out over the next 90 days as the budget is negotiated, and against the backdrop of a state - imposed Medicaid cap, uncertainty over the future of federal Medicaid funding and cries from long - term care facilities and home health care providers, which are also pleading for higher reimbursements.

That may prove difficult given the uncertainty around the future of Medicaid under a Donald Trump administration and the uncertainty surrounding efforts to replace the Affordable Care Act, which has cut the state's uninsured rate in half.

«It's living every day with the uncertainty of what your future may hold,» stated Pinto.

Prior to joining ECI, she completed her Ph.D. at Oregon State University, where she worked on the weather@home project over western US region, looking at drivers of extreme drought events in the US, future regional climate change projections over the western US, as well as investigating uncertainties due to internal variability and physical parameter perturbations.

The study of past warm climates may not narrow uncertainty in future climate projections in coming centuries because fast climate sensitivity may itself be state - dependent» http://www.pnas.org/content/110/35/14162.full

A battle over the future of Colorado's Cesar Chavez Schools Network, plagued by recent management problems and financial scandal, has created uncertainty in one of the state's most successful charter school groups.

Sixty - six of the state's 67 school districts did not spend all of the Chapter 1 money that was coming to them, electing to carry over some money as a cushion against future funding uncertainties, confirmed Cecil G. Carlton, director of the state's bureau of compensatory education.

Increasing uncertainty and apprehension about the future state of the economy and labor market, no doubt a result of the recent slowdown in job growth, are the primary reasons for the sharp reversal in confidence.

Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; Merck's ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of Merck's patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and / or regulatory actions.

Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; the company's ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the company's patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and / or regulatory actions.

Recommended reading The uncertainty ushered in by the choices of the electorate in Britain, the United States, and Italy have prompted much speculation as to the immediate future of the art market.

Looking particularly to the female perspective, the exhibition attempts to address this uncanny post-accelerationist body in its new surroundings, questioning our state of turmoil, loneliness, and uncertainty surrounding the future.

The study of past warm climates may not narrow uncertainty in future climate projections in coming centuries because fast climate sensitivity may itself be state - dependent» http://www.pnas.org/content/110/35/14162.full

We must also communicate the growth in model uncertainty as model predictions of the future advance farther and farther from the present climate state.

Uncertainty - An expression of the degree to which a value (e.g., the future state of the climate system) is unknown.

The current state of knowledge of atmospheric science leaves us with uncertainty about the future.

«The state of our knowledge about future climate change is such that the degree of uncertainty and the level of ignorance precludes formulating a PDF of outcomes -LSB-...]»

The state of our knowledge about future climate change is such that the degree of uncertainty and the level of ignorance precludes formulating a PDF of outcomes, or even putting bounds on the outcomes with a high confidence level.

By the way: «the degree of uncertainty and» should be scratched to attain accuracy: «The state of our knowledge about future climate change is such that the level of ignorance precludes formulating a PDF of outcomes -LSB-...] ``

Even in light of the complexities and uncertainties, Hulme et al. (2001) state that a «warming climate will nevertheless place additional stresses on water resources [in Africa], whether or not future rainfall is significantly altered» and they project reduced precipitation over Tunisia.

N (3) The computer climate models are not reliable or consistently accurate, and projections of future climate states are little more than speculation as the uncertainty and error ranges are enormous in a non-linear climate system.

The 19 - page guide states clearly,» It is not possible to determine exactly how much the Earth will warm or exactly how the climate will change in the future, but careful estimates of potential changes and associated uncertainties have been made».

The Earth has entered a new geological period in which human influence dominates the state of the planet, compounding uncertainty about the future.

Projecting the future water balance and moisture state of Arctic soils — and thus the ratio of CO2 to CH4 production — contributes the largest uncertainty in forecasting methane emissions from Arctic land surfaces.

However, uncertainty about the current state of Himalayan glaciers (4) and the future state of the climate, as well as an incomplete understanding of the processes affecting Himalayan glaciers under the current climate, make any projections of climate change's impact on glaciers uncertain as well (2, 23, 17, 39).

The RSE's web site states: «The science that indicates that climate change is resulting from greenhouse gas emissions is well established, with the only real uncertainty being the scale of the future changes.»

The uncertainty here stems in large part from the wording of Article 50 (2) TEU, which provides that the EU shall negotiate and conclude an agreement with a withdrawing state «setting out the arrangements for its withdrawal, taking account of the framework for its future relationship with the Union.»

If what a sovereign state offers to a business in return for it doing certain activity in that state is not something upon which the business can rely in the future, we have a degree of business uncertainty which is potentially catastrophic.

It's not all that surprising, given the nascent state of this industry and the asset in question but it does serve to illustrate the uncertainty surrounding the future of Bitcoin from an institutional perspective.

The current political climate in Russia and the Commonwealth of Independent States (CIS) has led to uncertainty over the future of oil and gas operations and projects in the region.

The problem with making satisfying interactions the main criteria of marital success is that it plunges partners into a permanent state of uncertainty about the future of the relationship, undermining the very good & 8212; both emotional and practical security & 8212; that moves men and women toward marriage.

Are you tired of being in a state of uneasiness, apprehension resulting from fear of future uncertainties (realistic or fantasized) then you are probably experiencing anxiety.

For instance, items such as «the longer the relationship, the more likely it will change», «relationships change as people are unpredictable» and «relationships change as change is the only constant in life», share the perceived uncertainty of the state and direction of the relationship in the future.

«Increasing uncertainty and apprehension about the future state of the economy and labor market, no doubt a result of the recent slowdown in job growth, are the primary reasons for the sharp reversal in confidence,» said Lynn Franco, director of Conference Board's consumer research center.

For instance, insufficient information about a potential economic recession, unsubstantiated rumors about future layoffs, or uncertainty about the closure of a sale and subsequent payment may result in a state of uncertainty.