Sentences with word «uncharacterized»

She studied a previously uncharacterized protein called YabA, which controls the binding of bacterial DNA to a protein called DnaA, whose essential role in kick - starting DNA replication had long been known.

Structural genomics analysis of uncharacterized protein families overrepresented in human gut bacteria identifies a novel glycoside hydrolase.

The findings suggest that Cell Painting may provide researchers with an inexpensive, high - throughput means to understanding the functions of uncharacterized genes — a category that currently includes more than 30 percent of the human genome.

We identify previously uncharacterized genes and variants associated with skin pigmentation in ethnically diverse Africans.

«We are also using the same high throughput screening technology to investigate a collection of more than 200,000 completely novel compounds with as yet uncharacterized biological activity in the hopes of identifying new classes of compounds with potent activity against CRE and other multi-drug resistant pathogens,» Kirby said.

This observation suggests that the bulk of genes involved in Nasonia immune response remain uncharacterized, with the current study being the first identification of additional candidate genes for immunity based on functional response to infection.

Using a specially designed computational tool as a lure, scientists have netted the genomic sequences of almost 12,500 previously uncharacterized viruses from public databases.

The study, which appears online October 29 in the journal Science Signaling, describes a previously uncharacterized interaction between GRK2 and an enzyme called endothelial nitric oxide synthase (eNOS), in which the two enzymes attempt to block one another's activity, with different outcomes on heart function.

The researchers are continuing their study of bacterial viruses in the hope of identifying compounds and processes that facilitate improved treatment of antibiotic - resistant bacteria using yet uncharacterized bacterial viruses» proteins.

1) This study reveals a previously uncharacterized role for RNA in beebread / pollen instead of protein, sugar and hormone in royal jelly to influence caste differentiation.

My lab is dedicated to explore the vast uncharacterized microbial diversity using cutting - edge culture independent technologies, such as single cell genomics and metagenomics.

They also suggest that «this strategy may facilitate control of... viruses uncharacterized at the molecular level, regardless of their genome type or variations in gene products.»

Many reports indicate that he is suffering from some serious illness, uncharacterized illness»...

The tumor - derived peptide is identical in biological activity and similar in physiochemical properties to the still uncharacterized growth hormone - releasing factor present in extracts of hypothalamic tissues.

We identify previously uncharacterized variants at HERC2 associated with the expression of OCA2.

Researchers at Tohoku University have identified a previously uncharacterized type of autophagy, during which an autophagic process termed chlorophagy removes collapsed chloroplasts in plant leaves.

«The PHPN is a hypothesis - generating tool, potentially capable of identifying yet uncharacterized common drug targets,» said Darabos.

«Even though we've sequenced the entire genome of Plasmodium falciparum, half of it still remains functionally uncharacterized.

Yao and Xia say their technique has already revealed a surprisingly critical role for a previously uncharacterized EB1 linker region in tracking microtubule plus - ends in live cells.

The structures and mechanisms necessary for this were largely uncharacterized until now.

It's obviously a boon for our genome center and an incredible opportunity to tackle some rare and uncharacterized cancers.

Overall, our data provide intriguing insights into the uncultivability, pathogenicity, and unique lifestyle of this previously uncharacterized oral TM7 phylotype.

Here, we identified a previously uncharacterized mammalian - specific protein, Beclin 2, which, like Beclin 1, functions in autophagy and interacts with class III PI3K complex components and Bcl - 2.

Researchers at the University of Helsinki and Karolinska Institutet have discovered previously uncharacterized mutational patterns in the human regulatory genome, in gastrointestinal tract and other cancers.

By comparing gene activation when enhancers were active or silent, they could identify the target genes of previously uncharacterized enhancers.

The players» task is to recognize patterns in microscope images of cells where proteins have been dyed in different colors; uncharacterized microscope images are compared with reference images showing the pattern of all major organelles and structures in the cell.

His recent published findings have included tracing the genetic origins of a previously uncharacterized brain disorder, establishing diagnostic criteria for Christianson Syndrome and showing how a genetic mutation of a gene associated with some autism forms in humans can hinder the proper growth and connectivity of brain cells in mice.

In a recent paper in the Journal of Biological Chemistry, Franziska Dierck of the University Medical Center of Schleswig - Holstein and colleagues write that they identified a previously uncharacterized z - disc protein named CEFIP upregulated in cardiomyopathy.

By blending classic biochemistry, molecular & cellular biology, and bioenergetics with large - scale proteomics and systems approaches, our lab aims to systematically annotate the functions of uncharacterized mitochondrial proteins (MXPs) and to establish the detailed mechanisms that drive essential mitochondrial pathways.

In two days, Doug (Justin Bartha) will marry Tracy (Sasha Barrese), who's rich, pretty and otherwise uncharacterized.

In addition to the early rcd1 - PRA and the late rcd4 - PRA there are also uncharacterized cases of PRA in many breeds, including the Irish Setter.

During the material health optimization process however, MBDC identified opportunities to optimize the materials and chemicals used for both manufacturers, replacing potentially hazardous or uncharacterized chemicals with chemicals that had been positively assessed.

Our approach is to use high resolution structural information for the generation of selective inhibitors (chemical probes) which we use to gain understanding of the functions of these largely uncharacterized proteins.

The experiments identified a previously uncharacterized gene as essential for intoxication by diphtheria toxin and exotoxin A toxicity, and a cell surface protein needed for cytolethal distending toxin toxicity.

Though some of the affected genes have been identified, the physical manifestations of these alterations remain largely uncharacterized.

James Collins, a professor of biomedical engineering at Boston University who was not associated with this research, says, «Efforts in synthetic biology to create complex gene circuits are often hindered by unanticipated or uncharacterized interactions between submodules of the circuits.

Uncharacterized bacterial structures revealed by electron cryotomography.

«Single cell genomics can be applied to understand the heterogeneity of tumors, to explain how genetically identical cells may show distinct behavior, and to explore the vast, uncharacterized microbial landscape.

It is not known at this time whether the PRA observed in a minority of Carriers of the IG - PRA1 risk allele is due to another, as yet uncharacterized, form of PRA or whether IG - PRA1 is inherited as a dominant trait with incomplete penetrance.

«A huge fraction of the human «proteome» remains uncharacterized, and this paper shows how chemical approaches can be used to uncover proteins of a given functionality that have eluded classification based on sequence or predicted structure,» said co-senior author Benjamin F. Cravatt, chair of TSRI's Department of Chemical Physiology.

Structural genomics analysis of uncharacterized protein families overrepresented in human gut...

Through systematic annotation of the resulting movies, we developed a phenotypic profiling system, which shows high correlation with cellular processes and biochemical pathways, thus enabling us to predict new functions for previously uncharacterized genes.