The experiments identified a previously
uncharacterized gene as essential for intoxication by diphtheria toxin and exotoxin A toxicity, and a cell surface protein needed for cytolethal distending toxin toxicity.
University of Michigan researchers have discovered a new cause of congenital myopathy: a mutation in a previously
uncharacterized gene, according...
These analyses eventually pointed to a previously
uncharacterized gene listed in the database — Gm7325.
It is likely that previously
uncharacterized gene products with intriguing effects on behavior will be discovered within these networks.
We identify previously
uncharacterized genes and variants associated with skin pigmentation in ethnically diverse Africans.
Through systematic annotation of the resulting movies, we developed a phenotypic profiling system, which shows high correlation with cellular processes and biochemical pathways, thus enabling us to predict new functions for previously
uncharacterized genes.
The sequence uncovers previously
uncharacterized genes encoding type IV pili, a surface polysaccharide and iron - acquisition systems.
The findings suggest that Cell Painting may provide researchers with an inexpensive, high - throughput means to understanding the functions of
uncharacterized genes — a category that currently includes more than 30 percent of the human genome.
Not exact matches
James Collins, a professor of biomedical engineering at Boston University who was not associated with this research, says, «Efforts in synthetic biology to create complex
gene circuits are often hindered by unanticipated or
uncharacterized interactions between submodules of the circuits.
They also suggest that «this strategy may facilitate control of... viruses
uncharacterized at the molecular level, regardless of their genome type or variations in
gene products.»
Though some of the affected
genes have been identified, the physical manifestations of these alterations remain largely
uncharacterized.
There is evidence that a substantial portion of the
uncharacterized risk for breast cancer is genetic, and this has encouraged the search for additional breast cancer predisposition
genes.
This observation suggests that the bulk of
genes involved in Nasonia immune response remain
uncharacterized, with the current study being the first identification of additional candidate
genes for immunity based on functional response to infection.
In some cases these seem to represent novel, previously
uncharacterized antimicrobial peptides, but many more of these immune - inducible
genes are difficult to characterize in the absence of detailed functional studies.
Naturally occurring inactivating mutations in
genes in humans represents a powerful entry point into this
uncharacterized biology.