The phrase
"uncharacterized genes" refers to genes whose functions and roles in the body are not fully understood or known yet. These genes have not been studied or described in detail, so they remain unknown regarding their specific functions, expressions, or implications.
Full definition
The findings suggest that Cell Painting may provide researchers with an inexpensive, high - throughput means to understanding the functions
of uncharacterized genes — a category that currently includes more than 30 percent of the human genome.
The experiments identified a previously
uncharacterized gene as essential for intoxication by diphtheria toxin and exotoxin A toxicity, and a cell surface protein needed for cytolethal distending toxin toxicity.
A cellular imaging technique called Cell Painting creates visual «signatures» that help reveal the functions
of uncharacterized genes or disease - associated gene variants.
Upon closer examination of the flies, the researchers found a mutation in a previously
uncharacterized gene, which they named hangover.
Through systematic annotation of the resulting movies, we developed a phenotypic profiling system, which shows high correlation with cellular processes and biochemical pathways, thus enabling us to predict new functions for previously
uncharacterized genes.
University of Michigan researchers have discovered a new cause of congenital myopathy: a mutation in a previously
uncharacterized gene, according...