But in some cancers — prostate, pancreatic, ovarian and lung in particular — the hedgehogs somehow turn back on, and
force uncontrolled cell growth: cancer.
The glands lining the inner wall of the colon are the sites for most abnormal cell behavior such
as uncontrolled cell growth, which results in polyps (non-cancerous growths) and later on in adenocarcinomas or tumors.
The model will describe cellular pathways that contribute to tumor formation and explain in detail how the genetic disposition of an individual can activate expression of genes that
drive uncontrolled cell growth and lead to cancer.
Cancer is characterized
by uncontrolled cell growth, which means the protein production machinery goes into overdrive to provide the building materials and control systems for new cells.
When estrogen is unchecked by progesterone it can
cause uncontrolled cell growth, which can lead to cancer, especially of the breast, ovaries and uterus.
Failure of this regulation not only impairs the process of development, but also contributes to the reversal of cell differentiation and
the uncontrolled cell growth that are the hallmarks of cancer.
Cancer is due to DNA modifications in a cell, which leads to
uncontrolled cell growth.
Head and neck cancers are a group of diseases involved abnormal,
uncontrolled cell growth in head and neck tissues.
In 1972, she identified a genetic glitch in chronic myelogenous leukemia cells — a swap of genes she called chromosomal translocation — that resulted in
the uncontrolled cell growth of cancer.
The loss of this regulation by Ezh2 «releases the brakes» on Gfi1 and leads to
uncontrolled cell growth.
While there are several different forms of cancer, they are all characterized by
uncontrolled cell growth that typically forms a lump or tumor.