The screen turned up some proteins that the Penn team had explored before but also a new one, a protein called BAG3, known as a chaperone protein,
which under normal physiological conditions acts to promote cell survival.
Glucose is the sole metabolic fuel used for nearly all brain
functions under normal physiological conditions, but the brain will metabolize ketone bodies for energy when access to glucose is limited, as would occur during water - only therapeutic fasting in humans or during calorie restriction in mice.
Now investigators at the University of Dortmund in Germany have figured out how to unlink
them under normal physiological conditions, potentially offering a controllable way to construct complicated nanostructures or devices that interact with the body.
Under normal physiological conditions, CXCR4 is mainly expressed in the hematopoietic and immune systems (Figure 1), where it carries out multiple functions.
Under normal physiological conditions the number of water molecules entering and exiting an aquaporin - expressing cell is the same, so that the total amount of water in each cell does not change.
With BAIT, Melov and other Buck faculty are building a resource for tracking how mice age, both in response to drug treatment and
under normal physiological conditions.
In neurons,
under normal physiological conditions, 95 % of APP is cleaved by the α secretase.
Under normal physiological conditions, ROS production is tightly regulated, and ROS participate in both pathogen defense and cellular signaling.