Sentences with phrase «undercarboxylated osteocalcin»

It is unclear whether the absolute amount of undercarboxylated osteocalcin or its ratio to total osteocalcin would be the best measure of its hormonal activity because no one to my knowledge has determined whether the carboxylated form interferes with the hormonal activity of the undercarboxylated form.

* Oddly enough, however, the experiments with fresh pancreatic islets and fat cells taken from the mice suggested that the positive effects of uncarboxylated osteocalcin on insulin only occurred at concentrations extremely low compared to those of undercarboxylated osteocalcin normally present in mice, while the effects on adiponectin and energy expenditure only occurred at normal to high concentrations.

For example, both increasing or decreasing the rate of bone resorption affects energy balance and testosterone, apparently via undercarboxylated osteocalcin, showing that departures from «normal» in both directions are effective, and thus that «normal» is within the effective range.

As mentioned above, genetic or pharmaceutical interventions to increase or decrease bone resorption not only controlled the release of undercarboxylated osteocalcin, but also produced the expected effects on energy metabolism and testosterone.

Without sufficient amounts of vitamin K2, undercarboxylated osteocalcin and MGP can lead to increased coronary calcification and cardiovascular disease.

In postmenopausal American women in the Framingham Offspring Study, for example, which did not account for whether anyone was supplementing with vitamin K, undercarboxylated osteocalcin ranged from zero to 91 percent, and averaged 17 percent.

Osteocalcin - deficient mice exhibit insulin resistance and hyperglycemia (27), and administration of undercarboxylated osteocalcin protects against the metabolic consequences of diet - induced obesity in WT mice (30, 60).

Although the metabolic effects of osteocalcin are still being elucidated (58, 59), several studies suggest that undercarboxylated osteocalcin regulates glycemic control and lipid metabolism in mouse models (27, 30, 60).

Not exact matches

In the present studies, the effects of musculoskeletal loading on serum osteocalcin in db / db mice were correlated with improvements in glycemic control and insulin sensitivity, but it is important to note that total, rather than undercarboxylated, osteocalcin was measured here.

If this paradigm is correct, one could argue that adequate vitamin K is needed to ensure that osteocalcin is fully carboxylated as it is produced, allowing it to accumulate in bone matrix, so that the presence of the undercarboxylated form in the bloodstream accurately reflects the degree of bone resorption.