Sentences with phrase «underlying aetiology»

Now we grope along without any idea about what is happening because we have no framework to understand the underlying aetiology of obesity.

Not exact matches

You need to understand the aetiology of obesity (the underlying cause) if you are to have any hope of treating it.

The negative effects seem to lie in the capacity of some foods / nutrients to stimulate proliferative pathways that in turn stimulate development of acne — suspect foods include those with a high glycaemic load and milk.11, 43, 44 Other evidence comes from several studies reporting that the prevalence of acne varies significantly between different populations and is substantially lower in non-Westernized populations that follow traditional diets, 45 a common factor among these traditional diets being a low glycaemic load.46 Various studies have provided evidence that high - glycaemic - load diets are implicated in the aetiology of acne through their capacity to stimulate insulin, androgen bioavailability and insulin - like growth factor - 1 (IGF - 1) activity, whereas the beneficial effects of low - glycaemic - load diets, apart from weight and blood glucose levels, also include improved skin quality.44 The clinical and experimental evidence does in fact suggest ways in which insulin can increase androgen production and affect via induction of steroidogenic enzymes, 47 the secretion by the pituitary gland of gonadotropin - releasing hormone and the production of sex hormone - binding globulin.48 Insulin is also able to reduce serum levels of IGF - binding protein - 1 increasing the effect of IGF - 1.49 These insulin - mediated actions can therefore influence diverse factors that underlie the development of acne such as:

The anti-emetic efficacy of maropitant (Cerenia ™) in the treatment of ongoing emesis caused by a wide range of underlying clinical aetiologies in canine patients in Europe.

The importance of considering GxE interactions in understanding the aetiology of complex psychiatric disorders has become more widely acknowledged (Caspi & Moffitt 2006; Canli & Lesch 2007; Munafo et al. 2009), yet the association between specific cultural and genetic factors underlying affective disorders across human populations has been largely unexplored until now.