Sentences with phrase «underlying complex diseases»

76/2: 45 A general analytical framework to identify pathogenic genes underlying complex diseases.

Not exact matches

But even when the genetic mechanism is more complex, he adds, the new approach might yield insights into underlying disease processes that could pave the way for more finely targeted treatments.

The team also discovered that genetic insults underlying Mendelian diseases do not appear to independently contribute to complex diseases but likely interact in a combinatorial way to ultimately cause the disorders.

Launched with a $ 215 million investment in the President's 2016 budget, the initiative aims to «give clinicians tools to better understand the complex mechanisms underlying a patient's health, disease, or condition, and to better predict which treatments will be most effective,» according to a statement issued by the White House.

«Aberrant splicing in humans may lead to various complex diseases and also underlies the development of some forms of cancer and the onset of neurodegenerative diseases, so a better understanding of the process can add important information for our fight against these diseases.»

«The approach may be extended to additional complex disorders and diseases for which we don't understand the underlying biology but do have drugs that may have some beneficial actions, such as depression, anxiety, schizophrenia and others in need of more effective therapies.

The objective of this project is to discover X-linked loci underlying various age - related complex diseases and normal aging while putting forth improved statistical genetic methods that are specially designed for ChrX.

We are now using these models to study the gene function and complex mechanisms underlying disease pathways, with a focus on genetic background effects, genetic modifiers and interaction partners.

We advocate instead to embrace the complexity and have developed approaches that allow us to uncover the underlying causes of human diseases no matter how complex.

However, a substantial proportion of patients defined as «complex» are often left without a molecular diagnosis, either because they are suffering from more than one rare disease or because the molecular mechanism underlying their disease can not be detected by NGS.

In conclusion, our study highlights the importance of studying gene — gene interactions in complex diseases and provides insights into the underlying cellular and molecular mechanisms.

My long - term research interests involve understanding the complex mechanisms underlying transcriptional regulation of human disease.

Most physicians are not adequately trained to address the underlying cause of complex, chronic disease and to apply strategies such as nutrition, diet, detoxification, exercise and stress management.

The underlying causes of autoimmune disease are multifactorial and complex, and until now, too little attention has been focused on determining the central causal factors.

In most anemic pets, an underlying disease is interfering with the complex processes that allows red blood cells to form within your pet's bone marrow.

The ideal treatment for glomerulonephritis is determined by identifying the underlying infectious, inflammatory or cancerous disease that is causing the immune system to create the immune complexes that are being trapped in the glomeruli.

However, it takes time and resources to discover genes underlying complex traits and diseases in any species.

Families and individuals living with severe, chronic, potentially life - shortening illnesses or disability often have multiple, complex, and interrelated problems that emerge as part of the underlying disease processes.