«We have revealed novel
components and connections in the regulatory network
underlying how these T cells mount an
immune response,» said study co-leader Kai Tan, PhD, of the Center for Childhood Cancer Research and the Departments of Pediatrics and Biomedical and Health Informatics at CHOP.
While it is not straightforward to directly compare the
immune repertoire reported here with previous reports that have used different
underlying gene models [15], [34], we do note that our inference about the number and identity of signaling
components is consistent with previous annotations [15], [34], while our inference about recognition and effectors tends to reflect greater, albeit still relatively minor, differences.