In the longer - term, the findings provide an important resource for exploring
the underlying mechanisms of resistance.
Not exact matches
This could be key given that the
underlying mechanisms of metastasis and
resistance to cancer drugs are nothing if not complex interactions in a biological system.
«Further research into the detailed
mechanisms underlying ASIS in naked mole - rats may shed new light on cancer
resistance in the mole - rats and contribute to the generation
of non-tumorigenic human - iPSCs, enabling safer cell - based therapeutics,» said Kyoko Miura, an assistant professor at Hokkaido University.
Another benefit
of the approach, Beisel says, is that «by targeting specific DNA strands through the CRISPR - Cas system, we're able to bypass the
mechanisms underlying the many examples
of antibiotic
resistance.»
Reporting
of extensively drug - resistant A. baumannii infection is not required by most public health jurisdictions in the United States, and clinical laboratories generally do not test for an organism's
underlying genetic
resistance mechanisms.
Further investigations could pave the way to a more complete understanding
of the genetics and metabolomics
of cell growth in yeast and the
underlying mechanisms relevant to other settings in which cells face challenging conditions, such as cancer progression and the evolution
of drug
resistance.
The
mechanism underlying the lack
of an effect
of MP in cerebellar DV in abusers is unclear but could reflect the effects
of chronic marijuana on cerebrovascular reactivity (increased cerebral vascular
resistance)(23 ⇓ — 25), which might have prevented MP - induced vasoconstriction and associated reductions in radiotracer delivery to the brain.
Understanding the
mechanisms underlying antifungal
resistance is a crucial part
of managing our limited antifungal repertoire, devising strategies to control C. auris spread, and predicting the pathogen's future outbreaks.
Although that study didn't specify the disease
mechanism at play, it's a well - known fact that excessive grain consumption leads to insulin
resistance — sooner or later — and that insulin
resistance is the primary
underlying factor
of most chronic disease, including cancer.
Also, mutations have been shown to be the
underlying mechanisms of general
resistance to thyroid hormone.