«Also, are these antibodies producing
symptoms in everyone or do they function as a probe
of an
underlying, perhaps genetic, vulnerability for
psychosis?»
The effort aims to facilitate a better understanding
of the
underlying mechanisms
of these
symptoms, which include
psychosis, agitation, apathy, depression and sleep disturbances.
Patients can find themselves on a whole pharmacopoeia
of drugs that address their NMS on a one - off basis, targeting individual
symptoms — sildenafil (Viagra ®) for erectile dysfunction, stimulants for daytime sleepiness and fatigue, clozapine for
psychosis, and even glycopyrrolate for frank, uncontrolled drooling — but again, these drugs do nothing to check the
underlying progression
of AS pathology, and the NMS continue to worsen over time.