Sentences with phrase «understand gene function»

Gene disruption in cells and model organisms followed by phenotypic analysis has been a traditional approach to understand gene function.

Ongoing comparative analysis will provide insights to help us understand gene function across all large animal species, including humans.»

This would allow them to better understand gene function in a variety of neurological disorders.

The light - activated genetic switch could be used to turn genes on and off in gene therapies; to turn off gene expression in future cancer therapies; and to help track and understand gene function in specific locations in the human body.

Construction of genetic models continues to be a most effective measure in understanding gene functions because loss of functional mutants accurately reflects non-redundant protein functions and elucidates the cellular impact of a protein of interest.

Understanding gene function can help you balance hormones and create an efficient detoxification system.

Not exact matches

Essentially the model reproduces the inner workings of all of the proteins within the organism and allows scientists to see everything from how cells interact with each other to the functions of genes in a larger context that had not been previously understood.

The EC has historically supported IRRI's work to conserve the genetic diversity of rice, understand the function of rice genes, and develop new rice varieties, particularly for use in difficult growing environments.

Genetic modification is a modern breeding method that is used at IRRI to investigate and understand the diversity and function of rice genes and to develop and deliver GM rice varieties.

Genetic modification is a useful tool to help us understand the function of genes.

«This is not only valuable to understand basic biological functions, but will also help investigating diseases that involve defective gene regulators.»

The answers could help open many doors in medicine and greatly expand our understanding of the functions of genes.

Better understanding of the association between genes, lung function and lung diseases The identified genes open up new molecular biological approaches for a better understanding of lung development and of the repair and remodelling processes during disease pathogenesis.

«This could mean that the reversal or suppression of pathological gene expression by beta blockers is somehow protective against heart failure, but it's something we would need to look into further to understand how individual genes function in the heart.»

Understanding the function of this gene — described this month in journal Molecular Psychiatry — could lead to more effective treatments for schizophrenia.

Since beginning a lab dedicated to understanding cancer metastasis at Rockefeller six years ago, Associate Professor Sohail Tavazoie has found that microRNAs — tiny strands of RNA that function as switches to inactivate specific genes — play an important role in controlling genes linked to metastasis.

This research tool can be used to better understand the function of histone proteins, which play critical roles in the regulation of gene expression in animals and plants.

We are currently experimentally studying the function of many of these genes to gain a better functional understanding of the plant microbiome.»

«If we want to engineer the right microbiome to support plant growth, we need to understand the real function of the microbiome and not just sequence marker genes,» said study co-first author Asaf Levy, a research scientist at the JGI.

«Gaining a better understanding of the functions genes perform in cells, whether plant or animal, is going to help us understand how to diagnose and treat diseases in humans,» says Richard K. Wilson of Washington University.

«Gene analysis adds layers to understanding how our livers function: Tracking gene expression patterns for 20,000 gene in 1,500 cells revealed a mosaic of activities.&raGene analysis adds layers to understanding how our livers function: Tracking gene expression patterns for 20,000 gene in 1,500 cells revealed a mosaic of activities.&ragene expression patterns for 20,000 gene in 1,500 cells revealed a mosaic of activities.&ragene in 1,500 cells revealed a mosaic of activities.»

Understanding the best ways to work with RNA and the various RNA detection methods can help scientists advance our understanding of gene expression patterns and elucidate the roles of different genomic elements in cellular function andUnderstanding the best ways to work with RNA and the various RNA detection methods can help scientists advance our understanding of gene expression patterns and elucidate the roles of different genomic elements in cellular function andunderstanding of gene expression patterns and elucidate the roles of different genomic elements in cellular function and dysfunction.

To understand how DIXDC1 mutations put normal brain function at risk, Cheyette's team turned to mutant mice that lacked a functioning copy of the gene.

Because these genes have the same function in zebrafish, humans, and other tetrapods, it should help researchers further understand how our ancestors left the water and evolved limbs from fins.

Given how useful any insights into gene function are for understanding the genetic basis of disease, the data are «priceless,» says Kári Stephánsson, a geneticist at deCODE in Reykjavík.

A better understanding of their functions related to body fat and obesity could provide a better picture of the roles these genes play in a variety of diseases.

The team anticipates their findings could be used understand how other non-coding RNAs function and to develop potential gene therapies to treat cancer.

The goal of the NIH program, as described on its website, is «to understand the principles behind the three - dimensional organization of the nucleus in space and time (the fourth dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.»

«If we want to understand how genes are turned on and off, we need to know where the sequences that perform this function are located in the genome,» said Mitchell.

The disease is caused by gene mutations that destroy the function of a protein whose physiological function is little understood.

The scientists also characterized the functions of some of these genes in the microglia, which contributed to an in - depth understanding of the developmental processes.

«We hope that in the future, by fully understanding how this gene affects signaling in the brain, we may be able to identify drugs to restore the normal signaling balance in neurons and improve cognitive and social function in patients,» says lead author Dr. M. Chiara Manzini.

«These findings help us to understand where in the body the function of this gene is vital and how the loss of the gene in certain tissues can give rise to Menke's disease,» said Petris, who is a researcher in the Bond Life Sciences Center and holds an appointment in the Department of Nutrition and Exercise Physiology.

Finally, the study provides an example of a highly integrative approach to understanding brain function at multiple scales, «linking genes and gene networks to the properties of single neurons and populations of neuron subtypes, all the way up to the level of animal behaviors,» said Okaty.

With further research into how these genes affect the brain, it could become possible to understand how genes linked to schizophrenia affect people's cognitive function,» said McIntosh.

Cebrià highlights that «as there are genes which are similar to egr - 4 in other lineages — for instance the human species — , this function may be particularly interesting to understand the process of regeneration in metazoans.»

Scientists are beginning to understand that genetic mutations are not the sole contributors to disease development and that the way in which genes are arranged in our cells can affect whether they function appropriately — that is, whether they are turned on or off.

Understanding enhancer functions is of great interest due to their importance in gene expression as well as evolution and disease.

Carlton devised a way of rapidly developing experimental mouse models, a staple of the translational field, to understand the function of novel genes.

Studying embryos of the little skate, Gillis focused on the gene Sonic hedgehog, which produces a signaling protein whose function is well understood in the mammalian limb.

«A better understanding of the brain region and cell type - specific binding targets of Hnrnph1 will tell us more about the function of this gene and possibly identify new therapeutic strategies for minimizing risk and treating psychostimulant addiction — a disorder for which there is currently no FDA - approved drug,» explained corresponding author Camron Bryant, PhD, assistant professor of Pharmacology and Experimental Therapeutics & Psychiatry at BUSM.

An improved understanding of the biological background of musical aptitude can contribute new insights into, for instance, genes that affect normal brain functions, the interactions between genes and the environment and the significance of music as a form of therapy.

«We now plan to apply this technology to dissect the process of invasion and understand what genes and proteins function at what step,» Rayner says.

Targeted gene therapies, however, had to wait for (1) the identification of the genes to target, (2) the cloning and / or sequencing of the relevant genes and in some cases, the specific disease - causing variant, (3) a full understanding of the normal gene function and regulation, and (4) the development of efficient ways to deliver genes to the relevant tissues at therapeutic levels.

«The collaboration of scientists with computational skills, others with population genetics and large - scale genomics knowledge, and those with in - depth understanding of gene function and interaction from the molecular to the whole - tree level is a major step forward,» she said.

This correlation between disease and functional modules can also inform our understanding of cellular networks by helping us to identify which genes are involved in the same cellular function or network module.

It is a real opportunity to explore the diversity of marine micro-eukaryotes which will help us to understand their relative importance through studying specifics such as their metabolic function from a gene repertoire to more broad concepts such as the identification of their ecological functions.

His efforts are directed toward understanding the nature and function of genes that control these processes and how disturbances in gene networks may lead to cancer.

One of the most important tools at our scientific disposal in understanding mammalian gene function is the laboratory mouse.

I must say, it is truly fascinating to understand how genes can influence the function of a cell.