Sentences with phrase «understand human immune responses»

Career Goals: I plan to pursue a career in scientific research focused on understanding the human immune response to various infectious agents for diagnostic and vaccine design purpose.

Not exact matches

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

The UNC research team, led by Lemon and Jason Whitmire, Ph.D., Associate Professor in UNC's Department of Genetics, is now poised to investigate the complicated interplay of nonspecific «innate» and specific «adaptive» immune responses that ultimately control the infection and eliminate HAV from the host — processes that are not well understood for any of the five human hepatitis viruses.

«These data provide the basis for understanding the immune response to filovirus infections in humans,» said Bukreyev.

Hypothesis driven approaches to vaccinology can utilise the knowledge gained from mechanistic mouse models and our molecular understanding of intrinsic defects to human cells.5 However, caution is required when extrapolating data from murine models, as there are substantial differences between immune ageing in mice and humans.6 Nevertheless, model systems and ex vivo analyses of molecular alterations in aged human cells have identified multiple changes in the vaccination response with age and the aged immune system in general.

For understanding the biology of gene - gene, gene - drug and gene - microenvironment interactions, a considerably broader range of in vitro and in vivo model systems is required — we are generating 1,000 organoid cultures from human cancers, characterising their genomes, functional dependencies and drug response, and we are expanding our in vivo models to study the interface between cancer and the immune system and microenvironment.

She continued describing human history with pathogens, showing how signals of ancient, pathogen - driven selection can be used to understand immune response.

It is based on the scientific understanding and high - throughput analyses of human immune responses to disease - related proteins in selected populations including elderly with the capability to stay healthy during the aging process.

In the proposed partnership between Addis Ababa University (AAU) and J. Craig Venter Institute (JCVI), the objective is to build genomics capacity at AAU and to apply newly developed skills towards understanding the relationships of active TB disease with Mtb strain type diversity and host components such as the human respiratory microbiome and protein - based analysis of immune responses in the respiratory tract.

Using gene - targeted mice and human cells that lack specific components of the immune system, a better understanding of the immune response to DENV and ZIKV is critical for developing much - needed vaccines and antivirals.

As current therapeutics are limited, it is essential to define the immune evasion strategies of these fungal pathogens which cause life - threatening infections and at the same time to understand the immune response of the human host to these fungal pathogens.