Sentences with phrase «understand human variation»

ASHG and its members are committed to become fluent in the language of the genome, understand human variation, and promote the public health as well as transfering new knowledge to the next generation of genetics professionals and the public in order to improve clinical practice.

Not exact matches

By considering the variations that can occur from one person to another, we can best understand the full range of human behavior.

Dr Tomi Pastinen, senior author on the second study, from McGill University said: «We have created an expansive, high - resolution atlas of variations that deepens our understanding of the interplay between the genetic and epigenetic machinery that drives the three primary cells of the human immune system.

Juries are willing to put people to death based upon the variations in DNA, but they're not willing to understand the mechanism that creates that variation and shapes what makes humans different from other things.

Although researchers do not yet know the biological significance of these discoveries, they say that fully cataloguing the genome may help them understand how genetic variations affect the risk of contracting diseases such as cancer as well as how humans grow from a single - celled embryo into an adult.

Stanford's Snyder is pleased about the growing push to understand human biological variation via personal connectome and other «- ome» profiles, such as metabolomes (the total metabolites present at a given time in our bodies) and proteomes (ditto for proteins).

The discovery sheds new light on our understanding of the genetic complexity underpinning variations in human pigmentation, and could advance our knowledge of conditions linked to pigmentation, such as skin, testicular, prostate and ovarian cancers.

«Thus, it is clear that further studies must investigate an increasingly complex matrix of cell types and conditions to fully understand the role of human genetic variation in disease.»

Her research is at the interface between bioimaging and proteomics, and aims to define the spatiotemporal organization of the human proteome at a subcellular level in an effort to understand how variations and deviations in localization contribute to cellular function as well as disease.

«NGS technologies have vastly improved our understanding of the human genome and its variation in diseases such as cancer,» said Ken Chen, Ph.D., assistant professor of Bioinformatics and Computational Biology and co-author of the Nature Methods article.

The start - up's mission is to understand the nature of human genetic variation and its impact on human disease (medical genomics) and treatment (pharmacogenomics).

Several lines of evidence suggest that a person's facial shape is controlled by one's genes, but scientists don't yet understand how genetic variation contributes to the range of healthy shapes and sizes that human faces take.

The work on gorilla and other human genomes clearly demonstrates that large swathes of genetic variation can't be understood with the short sequence - read approaches.

Entire swaths of human genetic variation, however, remain to be understood and we should push toward the routine de novo assembly of genomes as opposed to simply aligning to a reference for variant discovery.

Djimdé leads a research group at the University of Science, Techniques and Technologies of Bamako that is working to understand how genome variation in the Plasmodium falciparum parasite, its human host, and the Anopeheles gambaie mosquito vector contribute to the mechanisms of malaria disease spread.

Professor Segal's research has two major directions 1) Gene regulation — using quantitative and computational models to understand how DNA sequence variation among human individuals generates phenotypic diversity 2) Microbiome and Nutrition — understanding how the microbial composition of individuals affect their physiology and health.

Monitoring, understanding, and predicting oceanic variations associated with natural climate variability and human - induced changes, and assessing the related roles of the ocean on multiple spatial - temporal scales.

I was working in a community of people who were all thinking about looking at genetic variations, of how you might look at them and how you might understand them, and so reading lots of papers from other folks who were doing great work in that area I just looked at ways that you could basically go across the human genome and look at every variation, everything that's variable between human populations.

Identifying disease «hot spots» by studying variation across populations could help scientists better understand how genetics influence human health.

The next phase in our scientific understanding of human health and disease is to decipher the molecular basis of cell and tissue circuits and the impact of genetic variations on these circuits.

«Since the human genome was finished, one of the big efforts has been to try to understand and catalogue human variation.»

The Center for Research on Genomics and Global Health (CRGGH) aims to facilitate a global understanding of the relationship between human genetic variation and population differences in disease distribution, with the ultimate goal of informing health inequalities.

Exploration of these findings in the context of human disease genetics provides insights into the role of inherited variation in blood metabolic diversity and identify potential new opportunities for drug development and for understanding disease.

In this study we have integrated genome and transcriptome sequencing data to understand the landscape of functional variation in human populations.

It's this diversity of looks that make man's best friend the perfect laboratory for connecting sets of genes to particular traits and understanding the molecular mechanisms that govern variation in dogs as well as humans and other mammals.

He's interested in understanding how non-coding genetic variation contributes to human traits by integrating the genome and transcriptome.

As our understanding of the noncoding portion of the genome improves, it will become even more apparent that whole - genome sequencing (and not exome sequencing) will be required to characterize the full extent of phenotypically - relevant genetic variation in humans.

Dr. Vijayanand also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.

In 2003, two large - scale consortia undertook ambitious efforts to understand the variation and function in the human genome.

South Asian genetic landscape, bearing in mind its geographic, linguistic, socio - cultural and skin color diversity, offers an excellent model system to decipher the genetic underpinnings of human skin color variation and for a better understanding of it's evolutionary history.

His research focuses on understanding the role of genetic variation in contributing to human health and disease using mouse models of human disease, and more recently exploiting technologies developed for biomedical research for application in the field of genetic pest management.

Vijay also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.

Massively parallel sequencing (next - generation sequencing) has revolutionized research in cancer genetics and genomics [1] and enhanced our understanding of natural human genetic variation [2], [3].

Our research group is interested in the genetic basis of mammalian variation and its evolution, with an eye towards better understanding the human condition.

He stressed, though, that the latest study was only a first step and that future work on other living primates were necessary to better understand the range of variation within modern humans.

«GTEx will begin to provide researchers with a comprehensive view of genetic variation and a more precise understanding of how it affects genes critical to the normal function of tissues and organs,» said NIH Director Francis S. Collins, M.D., Ph.D. «This resource will add a new dimension to our understanding of human biology and the mechanisms that lead to disease.»

Race: A Teacher's Guide A substantive teaching tool to help middle and high school educators understand and address race and human variation, from the Race Project.

Whether studying behavioral, cognitive, or social - emotional development in children or the design of learning technologies to maximize understanding, you will gain a strong background in human development, the science of learning, and sociocultural factors that explain variation in learning and developmental pathways.

The course includes core concepts in relative management, such as, understanding the variation between universalistic and particularistic theories, evaluate then use and usefulness of theory, assessing the explanatory role of culture, relative approach to management and administration, theories of relative management and administration, human resources management practice

The lines of evidence and analysis supporting the mainstream position on climate change are diverse and robust — embracing a huge body of direct measurements by a variety of methods in a wealth of locations on the Earth's surface and from space, solid understanding of the basic physics governing how energy flow in the atmosphere interacts with greenhouse gases, insights derived from the reconstruction of causes and consequences of millions of years of natural climatic variations, and the results of computer models that are increasingly capable of reproducing the main features of Earth's climate with and without human influences.

The new atlas could also improve understanding of climate phenomena like the Atlantic Multi-decadal Oscillation, a variation in North Atlantic sea - surface temperatures that hasn't been tracked long enough to tell if it is a transitory event, forced by human intervention in the climate system, or a natural long - term oscillation.

The way I understand Murry's brief presentation is that he has found that natural variations in the carbon cycle are so large that the human contribution is pretty much irrelevant.

If we do not understand the time scale, even if it differs from place to place, we can not distinguish between the natural variations in weather and a climate change in which we want to identify the human component.

These shorter - term variations are mostly due to natural causes, and do not contradict our fundamental understanding that the long - term warming trend is primarily due to human - induced changes in the atmospheric levels of CO2 and other greenhouse gases.

Increased understanding about how environmental variations, such as socio - economic disparities, affect human brain development and behavior has significant implications for advancing basic scientific questions such as understanding genetic versus environmental contributions of brain and behavioral development.

Implications of the current findings for understanding culture — gene coevolution of human brain and behaviour as well as how this coevolutionary process may contribute to global variation in pathogen prevalence and epidemiology of affective disorders, such as anxiety and depression, are discussed.

Although evolution has shaped human infant crying and the corresponding response from caregivers, there is marked variation in paternal involvement and caretaking behavior, highlighting the importance of understanding the neurobiology supporting optimal paternal responses to cries.

One contribution of 14 to a theme issue «Understanding variation in human fertility: what can we learn from evolutionary demography?»