Sentences with phrase «understand immune response»

As current therapeutics are limited, it is essential to define the immune evasion strategies of these fungal pathogens which cause life - threatening infections and at the same time to understand the immune response of the human host to these fungal pathogens.

She continued describing human history with pathogens, showing how signals of ancient, pathogen - driven selection can be used to understand immune response.

The findings are significant because it helps researchers further understand the immune response to a virus such as Ebola and could lead to treatments for Ebola as well as other related viruses.

That study showed how a similar model can be used to understand immune response in patients with pancreatic cancer who survive longer than others.

«These data provide the basis for understanding the immune response to filovirus infections in humans,» said Bukreyev.

«Progress in understanding immune response in severe schistosomiasis.»

Dr. Alessandro Sette has devoted more than 30 years of study towards understanding the immune response, measuring immune activity, and developing disease intervention strategies against cancer, autoimmunity, allergy, and infectious diseases.

The laboratory is defining in chemical terms the specific structures (epitopes) that the immune system recognizes, and uses this knowledge to measure and understand immune responses.

AbScan is freely available and can be used for understanding the immune response in other cancers.

Not exact matches

A basic and simple understanding of the immune system including the basic premise of the immune response and the components of the non-specific immune system.

«This research represents a big step forward in understanding why some tumors are more aggressive than others and being able to predict rationally which neoantigens will be the most effective at stimulating an immune response,» said Dr. Balachandran, a member of the David M. Rubenstein Center for Pancreatic Cancer Research at MSK, and corresponding author of the companion study in Nature.

Understanding how dendritic cells are created will aid scientists in finding ways to boost the immune response to infections or dampen it in autoimmune diseases such as lupus and rheumatoid arthritis.

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

In addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapies.

As a basic researcher, he has been most interested in looking for ideas that point toward new directions in the field: a new role for a protein or a new understanding of how cellular proteins drive the immune response.

Professor Nutt said increasing our knowledge of the mechanisms that controlled the immune response was vital for understanding how immune and inflammatory diseases arise and, ultimately, developing more effective treatments.

The study grew out of a desire to understand the biology behind a basic part of the immune response.

Understanding the body's immune response to a given vaccine could help make better and more effective vaccines in the future.

Understanding how intestinal bugs alter the immune response of MS patients could help develop treatments, such as cocktails of anti-inflammatory bacteria or drugs, Quintana says.

To better understand how this abnormal distribution of B cell types in people with uncontrolled HIV affected their immune response to the virus, researchers compared HIV - specific antibodies derived from both TLM and RM B cells.

By understanding the genes and pathways involved in the immune response, we may be able to interpret the signals that determine whether an organism decides it is beyond repair or tries to regenerate.

Equipped with this deeper understanding, researchers are trying to make allergy vaccines safer and more effective by designing them to micromanage the allergic immune response.

«We have achieved the important goal of helping these young patients and made progress in understanding the biological pathways and proteins that are important for the regulation of the immune system's responses.»

Given the public health emergency that Zika virus poses, scientists are seeking to understand the Zika - specific immune response.

The UNC research team, led by Lemon and Jason Whitmire, Ph.D., Associate Professor in UNC's Department of Genetics, is now poised to investigate the complicated interplay of nonspecific «innate» and specific «adaptive» immune responses that ultimately control the infection and eliminate HAV from the host — processes that are not well understood for any of the five human hepatitis viruses.

The scientists conclude that the study reveals an essential function for CTCF in the orchestration of transcriptional changes during the terminal differentiation of B lymphocytes and advances understanding of the mechanisms that regulate the immune response.

Importantly, we need to ask whether the use of common biomarkers is good enough, or if a larger number of cytokines needs to be routinely measured to better understand the complexity of immune responses.

This discovery lays the groundwork for a better understanding of the role progenitor cells can play in immune system response and could lead to the development of more effective therapies for a wide range of diseases.

«These results represent a significant advance in our understanding of how commensal microbes can regulate host intestinal immune responses and suggest that the identification of downstream targets in macrophages and dendritic cells along the GM - CSF axis can help the rationale design of novel strategies for the treatment of IBD patients with defective GM - CSF function,» explained Dr. Merad.

Research is also underway to understand whether it can elicit a response against tumors that typically don't provoke an immune attack.

The study offers new information about LASV mutations and its replication in infected individuals that may help scientists understand how the virus causes infection and evades the immune response, and why clinical outcomes can differ so widely.

They say more research is needed to understand whether this level of virus suppression would be enough to halt disease transmission, and they are working on other experiments to see if they can produce antiviral factors in the gut, which could assist in inducing a stronger immune response and possibly confer resistance to the other viruses.

To understand how the different alleles influence the immune response to vaccination, the researchers next looked in more detail at immune cells from 47 of the patients (34 had two major T alleles, and 13 had at least one minor G allele).

The cholera studies led to the scuttling of a leading vaccine candidate, a finer understanding of effective immune responses, and, ultimately, compelling evidence that a different cholera vaccine worked.

As a means to better understand such pathogen - plant interactions, Chory's team turned to the well - studied weed Arabidopsis thaliana and, in particular, an enzyme called SOBER1 — which had previously been reported to suppress the weed's immune response to a bacterial protein known as AvrBsT.

The protein GATA - 3 plays an important role in mammalian immune response, but its overall function in cell development and cancer formation is not well understood.

This work brings us one step closer to understanding how the body's immune response works and what we can do to control it.

To better understand the nature of the immune response in PV, the researchers cloned anti-Dsg3 monoclonal autoantibodies (mAbs) from four unrelated PV patients.

A better understanding of the mechanisms responsible for suppressing the immune response to prevent such damage could benefit many patients.

Continued research could lead to a better understanding of how diet and nutrition affect immune function, and possibly lead to the development of therapeutically useful natural compounds that could boost the innate immune response, the researchers said in their report.

Scientists do not yet fully understand how the immune response is turned on and off and continue to study it in hopes of harnessing its power to cure disease.

Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the regulation of gene expression and modulation of the host immune response during ¿ - herpesviral infection.

Renal Carcinoma Immunology Laboratory: The overall goal of this laboratory research effort is to understand how renal tumors can inhibit the development of an effective anti-tumor immune response.

Kim et al. suggest that moving away from empirical research to either systems analysis or hypothesis driven approaches may advance our vaccinology understanding.5 Interrogation of peripheral blood responses following vaccination, termed «systems vaccinology», has led to the identification of immune signatures and pathways that are correlated to immune responses.

Fortunately, as a cutting edge research institute at the very heart of the HIV and TB co-epidemic, we are ideally placed to overcome these challenges and improve our understanding of the innate immune response to HIV, TB and their co-infection.

Hypothesis driven approaches to vaccinology can utilise the knowledge gained from mechanistic mouse models and our molecular understanding of intrinsic defects to human cells.5 However, caution is required when extrapolating data from murine models, as there are substantial differences between immune ageing in mice and humans.6 Nevertheless, model systems and ex vivo analyses of molecular alterations in aged human cells have identified multiple changes in the vaccination response with age and the aged immune system in general.

Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the regulation of gene expression and modulation of the host immune response during gammaherpesvirus infection.

We were interested in understanding regulation of T cell responses and I began to suspect that, in addition to positive signals that need to be given to initiate immune responses, there are also negative signals that no one had really thought of before that might limit responses.

We assess spontaneous and vaccine - induced immune responses against melanoma, and have a particular interest in developing methods for understanding functional subpopulations within melanoma and the optimal ways of targeting them therapeutically.

As such, genomic research is improving our understanding of infectious disease pathogenesis and immune response and may help guide future vaccine development and treatment strategies [11][18].