Sentences with phrase «understand mechanisms of resistance»
His research aims to understand mechanisms of resistance to targeted therapies in cancer and identify potential therapies to overcome that resistance.
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Dr. Douillard, lead author of the study, says his next steps are to «look for resistance mutations, like T790M, during treatment to better understand mechanisms of resistance and anticipate later line treatment at progression.»
Therefore, strategies for understanding mechanisms of resistance and determining how to therapeutically target specific gene fusion partners are also being explored.
Not exact matches
If only we had done this experiment 15 years ago, when vancomycin came into widespread use, we might have understood exactly what kind of resistance mechanisms would follow the drug into our clinics and hospitals.»
Although proteasome inhibitors are very efficient in selective killing of cancer tumor cells grown in a dish (in - vitro), their success in the clinic has largely been undermined by the development of resistance — mechanisms of which are poorly understood.
The initiative is great because it has three components: it leads to an increased understanding of resistance mechanisms, brings new candidate drugs forward, and provides a way to share data, including about what does not work.»
«Isolation of Stb6 is a major breakthrough that will allow deeper understanding of disease resistance mechanisms operating in wheat against this important pathogen,» says Kanyuka.
The emphasis now is to store samples from almost every major study with correlative science in mind, and this is essential if we are to understand disease biology, mechanism of response and resistance to therapy in the era of targeted therapy and precision medicine.»
With that comprehensive understanding of the structures and mechanisms behind bacterial resistance to antibiotics, Yu said his research group is beginning to look at how the pumps and transporters can be turned off.
Understanding the mechanisms by which resistance arises is essential for optimizing the clinical benefits of these drugs.
Further investigations could pave the way to a more complete understanding of the genetics and metabolomics of cell growth in yeast and the underlying mechanisms relevant to other settings in which cells face challenging conditions, such as cancer progression and the evolution of drug resistance.
Professor Bill Keevil, Chair in Environmental Healthcare at the University of Southampton and the paper's co-author, explains the significance of these findings: «It's important to understand the mechanism of copper's antimicrobial efficacy because microorganisms have evolved various mechanisms to convey resistance to disinfectants and antibiotics.
Understanding one of the mechanisms by which cancers develop resistance to drugs could in turn open up new ways to combat cancer.
«These data can contribute to a better understanding of the mechanisms that govern resistance or susceptibility to infection by Leishmania parasites upon transmission by the P. papatasi sandflies.»
However, our study clearly shows that the proportion of public and charitable funding for research into new antibiotics, understanding resistance mechanisms and ways of tackling resistance are inadequate for the size of the task.»
This may improve our understanding of resistance mechanisms and potentially offer new therapeutic entry points,» said James Collins, Ph.D., who is also the Termeer Professor of Medical Engineering & Science at Massachusetts Institute of Technology (MIT) and a Professor of Biological Engineering at MIT.
The study also may have broader implications for how clinicians approach the development of such treatments and understand mechanisms behind resistance to treatment in other cancers.
Drs. Baughn and Minato hope that the understanding of mechanisms for synergy will lead them and others to more potent drug combinations that can be deployed in the fight against pathogenic microbes as drug resistance becomes increasingly commonplace.
The researchers also suggest further research on the mechanisms of resistance and cross-resistance within the flea vector, to gain a fuller understanding of how insecticide develops and spreads across populations.
New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.
However, unfortunately, the vast majority of patients do not respond to checkpoint inhibition therapy and a minority of patients, who do respond to treatment, develop secondary resistance and experience relapse by mechanisms still inadequately understood.
Such a strategy will require a better understanding of the molecular mechanisms of antibiotic resistance, so in this study, the researchers solved the crystal structure of the resistance enzyme aminoglycoside phosphotransferase (4)- Ia in complex with the aminoglycoside hygromycin B.
Ultimately, the goals are to develop cost - effective genetic tools to determine whether a patient is carrying parasites that are drug resistant; to map the emergence of resistance; to understand the mechanisms and routes of spread of resistance; and to plan the most effective strategy to control and eliminate the problem.
«By understanding how the environment in which the parasite lives influences its susceptibility to drugs and the molecular mechanisms of drug resistance, we hope to be able to develop new intervention strategies to combat visceral leishmaniasis in Brazil.»
«In our model, stress conditions, such as a genetic variant or insulin resistance or a high - fat diet, lead to increased availability of the tribbles protein by as yet poorly understood mechanisms,» says Dr. Kulkarni, who is also an Assistant Professor of Medicine at Harvard Medical School.
These research studies improve our understanding of the disease by uncovering the mechanisms of response and resistance, potentially gaining insight that would allow us to predict the future patients who will benefit from each of these treatments and to develop new therapies that are even more effective.
Understanding the mechanisms underlying antifungal resistance is a crucial part of managing our limited antifungal repertoire, devising strategies to control C. auris spread, and predicting the pathogen's future outbreaks.
Moreover, our current understanding of possible antimicrobial resistance mechanisms in B. burgdorferi s.l. is limited and is largely founded on in vitro experiments on relatively few borrelial isolates.
Little research has been performed to understand the specific rules and mechanisms of minimal residual disease, including clonal evolution at the metastatic site, epigenetic programs, interaction with organ defense and immune systems, mechanisms of dormancy and re-awakening, and last but not least, mechanisms of therapy resistance in specific niches.
This residency will be the starting point for an investigation into the developing technology of VR and questioning our mechanisms and processes of understanding, desire, the unknown, fear and our physiological resistance to these digital worlds.