Thus, the discovery of DNA methylation in early diverging fungi helps the research community better
understand regulation of genes that encode the parts for bio-based economy and bioenergy applications.»
His group work on
understanding the regulation of gene expression, especially at the single - cell level where he has pioneered analytical approaches.
Not exact matches
This finding by Whitehead Institute scientists challenges current
understandings of gene regulation via DNA methylation, from development through adulthood.
This research tool can be used to better
understand the function
of histone proteins, which play critical roles in the
regulation of gene expression in animals and plants.
The quantum machine was also able to generate conclusions that were consistent with a biologist's current
understanding of gene regulation.
However, to make use
of that information required an
understanding of gene expression and
regulation, areas in which institute members made a conscious decision to invest and that became its strengths.
Plants perform these
regulations mainly by regulating nuclear
gene expression and multiple intracellular signaling pathways have been shown to play a role in the genomic response
of plants to stress, but the processes are not well
understood.
At the nucleic acid level,
understanding the precise
regulation of genes through analysis
of gene expression data will be
of utmost importance.
The research that led to these findings is part
of a larger effort to better
understand gene regulation and expression, carried out by the GTEx Consortium, a National Institutes
of Health - funded group that includes researchers from around 80 institutions founded in 2010.
Building on years
of mouse and
gene regulation studies, they have developed a resource that can help scientists better
understand how similarities and differences between mice and humans are written in their genomes.
She leads a multidisciplinary team integrating computational and experimental approaches to develop an
understanding of gene regulation in immune cells.
The publication
of the latest Canine genome build and annotation, CanFam3.1 provides an opportunity to enhance our
understanding of gene regulation across tissues in the dog model system.
«Using this approach, we will eventually be able to do the same thing you would do in English class — pick up a book
of haiku or Shakespeare and
understand that «this is a love poem,» or «this is an elegy,» because we'll
understand how the words — the DNA elements — are used in different contexts to convey different meanings on the
regulation of genes,» Arnosti said.
Targeted
gene therapies, however, had to wait for (1) the identification
of the
genes to target, (2) the cloning and / or sequencing
of the relevant
genes and in some cases, the specific disease - causing variant, (3) a full
understanding of the normal
gene function and
regulation, and (4) the development
of efficient ways to deliver
genes to the relevant tissues at therapeutic levels.
Along this line, our primary research goals are directed towards
understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the
regulation of gene expression and modulation
of the host immune response during ¿ - herpesviral infection.
He has made fundamental contributions to our
understanding of vertebrate developmental biology and microRNA - based
gene regulation using the model organism zebrafish.
«The knowledge gained will help us
understand many human disorders caused by malfunctions
of gene regulation, a major goal
of the NIH and
of our new Institute for Genomics and Systems Biology in Chicago» White said.
To
understand and analyze the
regulation of gene expression patterns, quantitative RNA sequencing is used.
Along this line, our primary research goals are directed towards
understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the
regulation of gene expression and modulation
of the host immune response during gammaherpesvirus infection.
Professor Segal's research has two major directions 1)
Gene regulation — using quantitative and computational models to
understand how DNA sequence variation among human individuals generates phenotypic diversity 2) Microbiome and Nutrition —
understanding how the microbial composition
of individuals affect their physiology and health.
Our laboratory focuses on
understanding gene regulation in the cardiovascular system, skeletal muscle, and other metabolic tissues, with the ultimate goal
of finding novel therapeutic strategies to prevent and treat cardio - metabolic and - myopathic diseases.
Several functions vary among the members
of this group
of bacteria, such as metabolism
of nitrogen, respiration, cell wall and capsule, stress response, secondary metabolite biosynthesis,
regulation and cell signaling; this variation in
gene functions could help us
understand the ability
of colonization and adaptability
of these rhizosphere - colonizing bacteria.
Throughout his postdoctoral years, at Memorial Sloane - Kettering Cancer Center, and into his tenure at the University
of Michigan, Dr. Al - Hashimi remained steadfast in his determination to solve the problem
of how to visualize atomic motion, «to obtain a deeper
understanding of gene regulation and to build new technologies for drug discovery and biotechnology.»
We study learning and memory at the genetic level to
understand the structure,
regulation, evolution and biological function
of genes that are required for normal learning and memory.
Research Focus: I dedicate my time and effort to develop high - throughput sequencing technologies such as single cell transcriptomic, ChIP - Seq, ChIA - PET, and many more... The scientific rational is to
understand better and with a different angle, the mechanisms
of epigenetic
regulation of gene expression in (rare) immune cells, pathologically relevant in many diseases such as asthma, SLE, tuberculosis...
We have a longstanding interest in
understanding gene expression
regulation, and in our wetlab at the Sanger Institute use mouse T helper cells as a model
of cell differentiation.
To
understand gene regulation, Panne works on a cell - free model
of the human interferon beta response to viral infection.
Methylation
of mammalian DNA and histone residues are known to regulate transcription, and the discovery
of demethylases that remove methylation in DNA and histones provide a basis for the
understanding of dynamic
regulation of mammalian
gene expression.
- The work, published in Nature Genetics, represents an important advance in our
understanding of gene regulation and reveals a new layer
of complexity that needs to be studied to properly interpret genomics and
gene expression in the future.
Major areas
of activity in our lab include 1) identification and characterization
of Sgenes, 2) genomic analyses to identify the diversity
of TAL effectors in pathogen populations and
understand their evolution, and 3) structural and biochemical studies to better harness the unique properties
of these proteins for applications such as targeted
gene regulation and genome editing.
The current findings could provide important clues to determine the culture conditions for promoting the differentiation
of primate ES cells into mature gametes, and to
understand molecular mechanisms
of primate gametogenesis including the timing
of germ cell induction, the
regulation of germ cell
gene expression, and the response to growth factors for germ cell differentiation.
Her scientific expertise lies in
understanding the epigenetic basis
of gene regulation during embryonic development and disease ontology.
To uncover molecular processes in individual cells and to
understand the full complexity
of biological systems, our lab applies and develops novel microscopy and genomics based techniques to study the
regulation of gene - expression in single cells.
A basic
understanding on the set
of genes and
gene networks responsible from directly regulating lifespan and the mechanisms used in this
regulation is also missing.
The single - cell perspective has helped to better
understand gene regulation and regulatory networks during exit from pluripotency, cell - fate determination as well as molecular mechanisms driving cellular reprogramming
of somatic cells to induced pluripotent stage.
The focus
of the Mar lab is to
understand how variability in
gene expression contributes to the
regulation of cellular phenotypes.
High fibre diets also contain various fatty acids such as the short chain fatty acids (SCFA) and the
understanding of synergistic effects
of SCFA and phytosterols in glucose
regulation and cholesterol homeostasisis important to our
understanding of diet, lifestyle and drugs in relation to peripheral amyloidosis and
gene expression
High fibre diets also contain various fatty acids such as the short chain fatty acids (SCFA) and the
understanding of synergistic effects
of SCFA and phytosterols in glucose
regulation and cholesterol homeostasisis important to our
understanding of diet, lifestyle and drugs in relation to peripheral amyloidosis and
gene expression that play an early role in the development
of AD.
We want to
understand this observation through the investigation
of gene regulation in the context
of the epigenetic landscape.
Respiratory sinus arrhythmia in the fourth decade
of life depends on birth weight and the DRD4
gene: Implications for
understanding the development
of emotion
regulation.