Sentences with phrase «understand signaling pathways»

A combined experimental and computational approach, to better understand signaling pathways that lead to genetic mutations, is at the core of this research.

Current projects in the laboratory include: 1) functional screens of ubiquitin ligases to identify novel cancer drug targets; 2) defining the molecular regulation of breast cancer metastasis to the brain; and 3) understanding signaling pathways that influence the response of cancer cells to chemotherapy.

Not exact matches

I was desperately interested in trying to understand how we could manipulate signaling pathways to improve the treatment of injuries.

Work spearheaded by professor Vicent Arbona is progressing in the understanding of the signaling pathway of a plant hormone that will make plants more resistant to stress by flooding.

Understanding how this signaling pathway functions would allow for development of strategies to protect crops against climatic change and to improve photosynthesis so as to generate biofuels and other valuable products.

By understanding the genes and pathways involved in the immune response, we may be able to interpret the signals that determine whether an organism decides it is beyond repair or tries to regenerate.

Understanding how this immune system is regulated at the appropriate level of activity gives the researchers more ideas of points in the immune signaling pathway that could targeted to increase the plant's baseline ability to resist disease.

Scientists study the germline of the roundworm Caenorhabditis elegans to identify the mechanisms that control stem cell proliferation and homeostasis, as well as to advance our molecular understanding of homologous signaling pathways humans.

Plants perform these regulations mainly by regulating nuclear gene expression and multiple intracellular signaling pathways have been shown to play a role in the genomic response of plants to stress, but the processes are not well understood.

«Making our inhibitors available could take basic research and the understanding of JAK signal pathways and their role in guiding the immune system a big step further in the future,» Laufer says.

Jasper says TOR can be regulated by a number of stimuli, and researchers are now attempting to better understand how the activity of this signaling pathway is controlled in stem cells.

Researchers aiming to understand why autism spectrum disorders (ASD) are more common in boys have discovered differences in a brain signaling pathway involved in reward learning and motivation that make male mice more vulnerable to an autism - causing genetic glitch.

At a clinical level we need to understand where we can interfere or intervene with the signaling pathway to the benefit of the patient.

An understanding of how these noise features differentially affect signal encodings along the auditory pathway would require further experiments utilizing a broader set of background noises.

«I believe that the result of this collaboration not only sheds light on the long sought mystery of arabinogalactan sugar chains but will also advance the understanding of the yet to be resolved signaling pathway between cells involving sugar chains.»

The actin cytoskeleton mediates these responses, but the signal transduction pathway leading to chloroplast movement and the mechanism of chloroplast motility is not entirely understood.

What's next: Important follow - on studies include using these initial discoveries to design targeted efforts for understanding the specific signaling pathways under EGFR transactivation.

To better understand how insulin signaling affects beta - cell growth, the Joslin scientists next studied a pathway involving a protein called FOXM1.

The research described in this essay focused on understanding this pathway by identifying protein factors that form a lysosome - based signaling platform that positively and negatively regulates the function of the Rags.

Her goals are to continue working to understand how the dynamics of p53 and other signaling pathways important in cancer control cell fate decisions.

This landmark revelation was the first definition of an entire cellular signaling pathway from the cell surface to the nucleus, providing an important paradigm for understanding intracellular signaling.

Systems biology is an approach to biomedical research in which scientists combine complex «omics» datasets to develop a more complete understanding of complex biological systems, such as the regulation of whole genome - level transcription, regulation of the 3D genome, the role of signaling and metabolic pathways in disease, and more.

Her research focuses on understanding how signaling pathways control gene expression, using T cells and other cells of the immune system as models.

However, other signaling pathways, including MAPK, are less well understood.

«Knowing the subcellular location of a given protein is of great importance as it indicates the protein function and leads to a better understanding of how and why proteins interact in networks and signaling pathways.»

The team found that Zoloft acted on the worms» GABA signaling in a neuron that affects the animal's sleep, pointing to a potential pathway to understand why Zoloft works in some people and not others.

The Ellerby lab is known for its pioneering studies on Huntington's disease (HD), and Karen is now using human stem cell models of HD to understand why important molecular signaling pathways, such as the TGF - β pathway, are dysregulated in HD.

The broad conservation of neurohormonal signaling pathways between mammalian systems and C. elegans such as insulin - like signaling, serotonin, etc., validates studying the cell non-autonomous control of protein homeostasis by the nervous system of C. elegans to instruct our understanding of age - related human disease.

The advanced understanding of the mechanisms underlying Oligophrenin1 - related ID, allowed us to develop a therapeutic approach targeting the RHOA / ROCK signalling pathway and repurpose Fasudil - a well - tolerated ROCK and PKA inhibitor - as a treatment of ID.

Dr. Doyle's laboratory focuses on understanding the initial signaling pathways activated during an inflammatory response.

Signaling pathways which contribute to regulation of Oct4 stability and transactivation have not been identified previously; indeed, this area remains a conspicuous «black box» in our understanding of the circuitry which controls pluripotency.

But trying to understand the nerve signalling pathways involved is a gargantuan task, given the complexity of the human nervous system, with its billions of neurons and trillions of connections between them.

May 11, 2015 Disrupting cancer pathway could enhance new immunotherapies Understanding how to overrule a signaling pathway that can cause treatments to fail in metastatic melanoma patients should help physicians extend the benefits of recently approved immunity - boosting drugs known as checkpoint inhibitors to more patients.