Sentences with phrase «understanding cell development»
«Therefore,» Nogales continued, «gaining insight into how PRC2 function is adjusted both in space and time is crucial to understanding cell development.»
https://www.sciencedaily.com/ Not exact matches
In fact, the latest research in epigenetics, stem cells, and the developmental origins of health and disease is unlocking a whole new line of understanding of what breastmilk contains and its role in development.
However, the prime minister stressed the public at large must understand and accept new scientific developments such as the MMR vaccination, stem cell research and GM foods.
Improved understanding of the biology of cancer cells has led to the development of biological agents that mimic some of the natural signals that the body uses to regulate growth.
In a groundbreaking study that provides scientists with a critical new understanding of stem cell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embcell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embCell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embryo.
To start with human stem cells will be a powerful way to understand what goes on in the development of human physiology.
Although proteasome inhibitors are very efficient in selective killing of cancer tumor cells grown in a dish (in - vitro), their success in the clinic has largely been undermined by the development of resistance — mechanisms of which are poorly understood.
«As scientists, we have focused a good deal of attention on understanding the role of stem cells in the development of cancers, but there hasn't been a focus on mature cells,» said senior investigator Jason C. Mills, MD, PhD, a professor of medicine in the Division of Gastroenterology.
Development of new therapies for the prevention and treatment of prostate cancer bone metastasis depends on understanding the dynamic reciprocal interactions between prostate cancer cells and the bone microenvironment.
«With the rise of new and unproven stem cell treatments, the NFL faces a daunting task of trying to better understand and regulate the use of these therapies in order to protect the health of its players,» said Kirstin Matthews, the Baker Institute fellow in science and technology policy and an expert on ethical and policy issues related to biomedical research and development.
But like the medieval alchemists, today's cloning and stem cell biologists are working largely with processes they don't fully understand: What actually happens inside the oocyte to reprogram the nucleus is still a mystery, and scientists have a lot to learn before they can direct a cell's differentiation as smoothly as nature's program of development does every time fertilized egg gives rise to the multiple cell types that make up a live baby.
In the future, our technique could help people understand the details of a disease by providing snapshots of proteins synthesized in specific cells at different times during development and allowing comparisons of healthy and diseased cells.
These techniques are key to understanding the molecular mechanisms underlying cell function in healthy and diseased individuals and the development of diseases like cancer.
«In addition to advancing our understanding of human embryonic development, the findings suggest we may be able to use metabolites, relatively simple compounds, to alter cell fate in the treatment of common disorders.»
Fresh insights into how our cells control muscle development could aid understanding of muscular dystrophy and other inherited diseases.
DNA sequences were once thought to be identical from cell to cell, but it's increasingly understood that mutations can arise during brain development that affect only certain groups of brain cells.
The researchers also observed that 6 - week - old germ cells created in the lab do not match a 6 - week - old human germ cell, suggesting that there is a blockage in the development of lab cells that scientists are failing to understand.
«With a better understanding of how potential is regulated, it could be possible to broaden the development spectrum of aging stem cells, allowing them to regain their capacity to produce cell types from earlier development stages, which in the long - term perspective could be relevant to future treatment methods for neurodegenerative disease.»
Understanding the coordinated development of motor neurons and glia may inform ways to prod stem cells into generating more glia after someone suffers an injury with nerve damage.
«Scientists discover stem cells that build a fly's nervous system: Study in fruit flies sheds light on key aspect of development; findings could build understanding of comparable system in people.»
Therefore, the insights of Dr. Melendez and her colleagues may deepen our understanding of cancer and aid in the development of therapies against malignant cell growth.
To understand the development of the human brain, the researchers looked to a much simpler animal, the fruit fly, in which they could control and observe cells more easily.
Though a range of developmental scenarios in multiple brain regions is surely at work in ASDs, the researchers said the ability to place these specific genetic mutations in one specific set of cells — among hundreds of cell types in the brain, and at a specific point in human development — is a critical step in beginning to understand how autism comes about.
The team's insights not only illuminate normal vertebrate development but also could lead to improved understanding of human spinal defects such as scoliosis, said Pourquié, who is also the Harvard Medical School Frank Burr Mallory Professor of Pathology at Brigham and Women's Hospital and a principal faculty member of the Harvard Stem Cell Institute.
«LEVER 3 - D is amazing, it opens new vistas for understanding the stem cell niche,» said Dr. Sally Temple, a cell biologist at the Neural Stem Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2cell niche,» said Dr. Sally Temple, a cell biologist at the Neural Stem Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2cell biologist at the Neural Stem Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2cell research since 2005.
Apart from advancing our understanding of how plants regulate their growth and shape, this research presents new questions for stem cell researchers in regards to cell size checkpoints and their importance during organism development.
This discovery lays the groundwork for a better understanding of the role progenitor cells can play in immune system response and could lead to the development of more effective therapies for a wide range of diseases.
Professor Knight added: «Super resolution microscopy is a major step forward and we are looking forward to using this technology in a wide range of applications from stem cell behaviour to understanding arthritis or the development of nanomedicine.»
This led to development of newer technology, called single cell sequencing (SCS), that has had a major impact in many areas of biology, including cancer research, neurobiology, microbiology, and immunology, and has greatly improved understanding of certain tumor characteristics in cancer.
«We're looking at the genes and gene networks involved in stem cell proliferation, meristem development and flowering and branching,» said Van Eck, «with the end goal being that maybe genes that we identify in tomato, which is strictly being used as a model, might help us understand what can be done to increase yield in other crops.»
He adds, «Exciton diffusion and transport are important processes in solar - cell devices, so understanding what limits these may well help the design of better materials, or the development of better ways to process materials so that energy losses during exciton migration are limited.»
Many researchers are already using stem cell lines in drug development, and to further understanding of often - complex diseases.
This marks only the second time researchers have generated a whole organ from a single stem cell, representing major advances for stem cell research and our understanding of prostate development, experts say.
The protein GATA - 3 plays an important role in mammalian immune response, but its overall function in cell development and cancer formation is not well understood.
The results have implications for understanding male infertility as well as cancer development and were published in the journal Cell Stem Cell.
For more than 20 years, Van Blerkom has been trying to understand the story that egg cells are telling, and although the tale is far from complete, some compelling new clues to early development have emerged.
The discovery of cells» ultra-sensitivity for mechanical property of their environment is crucial to understanding basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.
Knowing how cells exert force and sense mechanical feedback in their microenvironment is crucial to understanding how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion — basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.
«Our focus here has been on early heart development, but the basic principles of patterning of human pluripotent stem cells, and subsequently differentiating them, can be readily expanded into a broad range of tissues for understanding embryogenesis and tissue morphogenesis,» said Healy.
For example, he says, researchers studying infertility have grafted human testis and ovary cells under the skin of animals in an effort to better understand their development.
Although we know that chemicals in tobacco smoke cause mutations in lung cells that lead to lung cancers and ultraviolet light causes mutations in skin cells that lead to skin cancers, we have remarkably little understanding of the biological processes that cause the mutations which are responsible for the development of most cancers.
Scientists are beginning to understand that genetic mutations are not the sole contributors to disease development and that the way in which genes are arranged in our cells can affect whether they function appropriately — that is, whether they are turned on or off.
The research highlights the importance of investigating different cell types in normal human tissues to understand the cellular origin of cancer and the factors that may contribute to its development.
«For a stem cell therapy for Duchenne to move forward, we must have a better understanding of the cells we are generating from human pluripotent stem cells compared to the muscle stem cells found naturally in the human body and during the development process.»
Ultimately, this knowledge will be useful for understanding the very early events in human development, which are reflected in the naïve and primed stem cell states, and could also lead to improved methods to reprogram human cells for stem cell - based therapies.
But studying these genes, many of which play roles in brain cell development, may ultimately help scientists understand how intelligence is built into brains.
This information is crucial to understand how cells maintain their identity and protect their genome, which is essential to avoid cancer development,» says associate professor Anja Groth, who has been heading the research team.
The study has important implications for human health, and is particularly useful for understanding the changes that occur in cells during the development of the tumors that underlie cancers.
«Our data give us a new, detailed understanding of the intercellular communication between developing liver cells, and shows we can produce human liver buds that come remarkably close to recapitulating fetal cells from natural human development.»
Interestingly, genomic analyses suggested that ESCC and head and neck squamous cell carcinoma (HNSCC) shared some common pathogenic mechanisms, and ESCC development is associated with alcohol drinking.These findings would provide a brand - new insight into the understandings of ESCC tumorigenesis, and would help clinicians to develop more effective diagnostic and therapeutic approaches for ESCC.