Sentences with phrase «understanding cell differentiation»

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«I think it will mark a paradigm shift» in how scientists understand stem cell differentiation, he adds.

The new technique could also be useful in understanding how stem cells change oxidation properties during differentiation into other cell types.

They also are key to cell differentiation in developing organisms, but the mechanisms are not fully understood.

But like the medieval alchemists, today's cloning and stem cell biologists are working largely with processes they don't fully understand: What actually happens inside the oocyte to reprogram the nucleus is still a mystery, and scientists have a lot to learn before they can direct a cell's differentiation as smoothly as nature's program of development does every time fertilized egg gives rise to the multiple cell types that make up a live baby.

Mouse embryos: Scientists first found embryonic stem cells in mice in the 1970s, but an understanding of the critical role they play in cell differentiation only emerged years later.

Because these organisms are excellent models for understanding stem cell biology, researchers were able to shed light on the earliest stages of follicle cell differentiation, a previously poorly understood area of developmental biology.

«This study can further our shared understanding of how the microenvironment can regulate the differentiation and fate of a progenitor or stem cell.»

Understanding the mechanisms that regulate the self - renewal and differentiation of stem cells is important, in order that stem cells can be effectively and safely utilised in medical applications in the future.

I've still kept my own lab going focusing on understanding what pluripotent stem cells really are, and the extrinsic signals that govern their self - renewal and differentiation.

Knowing how cells exert force and sense mechanical feedback in their microenvironment is crucial to understanding how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion — basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.

This inefficiency is partly due to a poor understanding of the molecular mechanisms controlling the differentiation of these cells.

«Researchers apply brainpower to understanding neural stem cell differentiation.»

Fetal development in mammals is becoming well understood in terms of the causes of cell differentiation and gene activation.

In a relatively short period since its foundation in 2002, the CRG has generated important scientific insights in our understanding of the organization, deployment and evolution of genetic information, the internal workings of cells, their differentiation and reprogramming, their collective organization to form tissues and their alterations in disease, including cancer.

We are investigating the roles of various transcription factors, kinases, and molecules involved in intracellular vesicular traffic in order to understand the differentiation of Vα14 iNKT cells.

The exploration of the therapeutic potential of stem cells requires the characterization of their biological properties, the deciphering of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding of the signals that direct their fate towards discrete cell phenotypes... Their therapeutic use requests further, in particular in the case of substitutive therapies, the analysis of their capacities of integration in injured adult tissues and of their potential tumorigenicity, as well as the development of original ways of delivery.

Human iPS cell - derived hepatocytes differentiated with our robust differentiation protocol and cultured using our novel maintenance medium provide an inexhaustible, consistent supply of functional hepatocytes that can be used to advance the understanding of diseases related to dysfunction in liver metabolism, including NAFLD / NASH, type 2 diabetes, and metabolic syndrome.

In addition to p53, there are other transcriptional activatory mechanisms that are not well understood for the most part and which operate in response to mitogenic stimulation (11, 12), transforming growth factor - β (13, 14, 15), and aberrant oncogenic signals (16, 17) or during a number of cell differentiation processes (18, 19).

«This new understanding of the role played by scrawny may make it easier to expand stem cell populations in culture, and to direct stem cell differentiation in desired directions,» says Spradling.

Understanding how individual stem cells engage into differentiation or remain in a non-differentiated, quiescent and / or self - renewing state.

Human iPS cell - derived hepatocytes differentiated with our robust differentiation protocol and cultured using a novel maintenance medium provide an inexhaustible, consistent supply of functional hepatocytes that can be used to advance the understanding of diseases related to dysfunction in liver metabolism, including NAFLD / NASH, type 2 diabetes, and metabolic syndrome.

We aim at understanding (1) the regulatory properties emerging from and the constrains imposed by the modular and dynamic organisation of the network; (2) the epigenetic mechanisms ensuring the rapid reestablishment of the network after each cell division and, conversely, those promoting its dismantling upon differentiation; (3) the contribution of non-coding RNAs to the regulation of the network's activity.

Professor Smith was awarded the prize for his seminal contribution to understanding the mechanisms governing the renewal or differentiation of stem cells, a vital stage in the development of cell treatments.

The new knowledge and target candidate genes resulted from such unbiased study are ultimately important for researchers to understand the fundamental nature of stem cell proliferation and differentiation.»

Starting my lab beginning of 2015 in Dresden we will focus on understanding the role of membrane organization during cell differentiation and tissue formation.

Understanding the principles of continuous regeneration and cell differentiation is a prerequisite to modulate hematopoiesis.

Dissecting the roles of mitochondria in stem cell homeostasis and differentiation is essential to understand stem cell dynamics and fate.

We have a longstanding interest in understanding gene expression regulation, and in our wetlab at the Sanger Institute use mouse T helper cells as a model of cell differentiation.

This study, published in Science, will help researchers understand why and how stem cells transition through states of differentiation through their different molecular properties.

The current findings could provide important clues to determine the culture conditions for promoting the differentiation of primate ES cells into mature gametes, and to understand molecular mechanisms of primate gametogenesis including the timing of germ cell induction, the regulation of germ cell gene expression, and the response to growth factors for germ cell differentiation.

By identifying, activating and inhibiting critical signaling nodes in cells, the scientists seek to better understand how these drive responses such as cell death and differentiation.

Research in Dr. Sun's laboratory is focused on understanding the mechanisms regulating T cell differentiation, and developing targeted therapeutics based on these mechanisms.

usage of model organisms to understand and exploit the mechanisms controlling stem and precursor cell generation, maintenance, activation, recruitment, proliferation, homing and differentiation,

The use of embryonic stem cells as therapeutics requires firm understanding of the mechanisms that control their proliferation and differentiation.

In order to better understand how the scientists have come to this conclusion, one needs to get familiar with cell differentiation markers.