Sentences with phrase «understanding cellular function»

RNA - based gene regulation is revealing itself as key to understanding cellular function, organismal development and homeostasis.

Not exact matches

Although much of the cellular and sub-cellular functions of the human brain remain unknown, the insights we currently have paint a more nuanced understanding of human nature, which in turn helps shape our understanding of politics, IR theory, and global order.

Close collaboration between the Pasteur Institute and Inria, taking the form of the InBio join research group, whose aim is to develop a methodological framework for achieving a quantitative understanding of the functioning of cellular processes, is the perfect illustration of the value of interdisciplinary research combining experimental approaches with methodological developments.

Allan Jacobson, Ph.D., of the University of Massachusetts Medical School and co-founder of PTC Therapeutics, the company that developed ataluren, and David Bedwell, Ph.D., professor of the UAB Department of Biochemistry and Molecular Genetics, have sought to understand precisely how ataluren allows the ribosome, the machinery of cellular protein synthesis, to skip over these inserted stop signs and produce proteins that have normal or near - normal function.

Clinicians are well - versed with the human body and the delicate use of surgeries and drugs, while scientists understand the intricacies of how the body functions at the molecular and cellular level,» he explains.

RNA, widely known as a cellular messenger that makes proteins and carries out DNA's instructions to other parts of the cell, is now understood to perform sophisticated chemical reactions and is believed to perform an extraordinary number of other functions, at least some of which are unknown.

Understanding the best ways to work with RNA and the various RNA detection methods can help scientists advance our understanding of gene expression patterns and elucidate the roles of different genomic elements in cellular function andUnderstanding the best ways to work with RNA and the various RNA detection methods can help scientists advance our understanding of gene expression patterns and elucidate the roles of different genomic elements in cellular function andunderstanding of gene expression patterns and elucidate the roles of different genomic elements in cellular function and dysfunction.

Her research is at the interface between bioimaging and proteomics, and aims to define the spatiotemporal organization of the human proteome at a subcellular level in an effort to understand how variations and deviations in localization contribute to cellular function as well as disease.

The goal of the NIH program, as described on its website, is «to understand the principles behind the three - dimensional organization of the nucleus in space and time (the fourth dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.»

Previously, understanding a patient's condition relied on analysis of symptoms and signs, such as lung function measurements and airway hyper - responsiveness, but now clinicians can access information about a range of other underlying complex biological traits, including cellular and molecular traits.

Knowing how cells exert force and sense mechanical feedback in their microenvironment is crucial to understanding how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion — basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.

«Now that we have the cellular and molecular information, the future promises to be very exciting when this knowledge can be used to understand how this system is formed during gestation and how the different neuron types go about controlling the body's functions,» says study leader Patrik Ernfors, professor of tissue biology

«While it is well - established that obesity generates cellular and molecular stress leading to abnormal functioning of many cellular processes, the mechanisms remain incompletely understood,» said senior author Gökhan S. Hotamisligil, chair of the Department of Genetics and Complex Diseases and the Sabri Ülker Center for Nutrient, Genetic, and Metabolic Research.

This correlation between disease and functional modules can also inform our understanding of cellular networks by helping us to identify which genes are involved in the same cellular function or network module.

Construction of genetic models continues to be a most effective measure in understanding gene functions because loss of functional mutants accurately reflects non-redundant protein functions and elucidates the cellular impact of a protein of interest.

The research focus of the laboratory is to better understand the functions of ADAR and the cellular processes regulated by A-to-I RNA editing and to identify possible human diseases caused by malfunction of these processes.

These studies will provide new leads to understand the cellular pathways that control K2P function in other organisms.

At Weizmann, Dr. Spiegel will be establishing his own independent research group which will attempt to identify the molecular and cellular mechanisms through which experience alters the structure and function of neural circuits in the brain in behaviorally relevant ways and to understand how these processes, when they go awry, might give rise to psychiatric disorders.

Studying coral calcification with antagonists can provide further information and knowledge to better understand the role and function of genes that participate in the cellular control mechanism, and in the coral organic matrix.

Building on these extreme examples that emphasize the potential roles played by healthy lysosomes in protecting neurons against the age - dependent accumulation of toxic cellular debris, we ultimately seek to understand how neurons sense and regulate the status of their lysosomes, how lysosomes are affected during age - related disease states and whether lysosomal function can be modulated for therapeutic purposes.

Their crisscrossing paths and collective efforts have nonetheless led to a clear - eyed understanding of how neurons — the brain's cellular building blocks — form and function and how ion - conducting channels control the flow of electrical signals through the nervous system.

Scott Henderson, who has been directing microscopy core facilities for nearly 25 years, loves to talk about how such facilities help scientists explore essential cellular functions and gain a better understanding of the mechanisms associated with disease.

My research interest is to understand the neuroendocrine mechanisms that regulate reproductive function and behaviors at molecular, cellular, and systemic levels.

As we gain a deeper understanding of the cellular regulation mechanisms of Tau function, we will shed more light on the complex role of Tau in the aetiopathogenesis of neurodegeneration.

As part of the Genomics, Development and Disease Section (GDDS), Dr. Loftus» research focus is on understanding the cellular processes regulating melanocyte function.

Elizabeth B. Moloney, PhD, is a post-doctoral research fellow at the Neuroregeneration Research Institute at McLean Hospital, where she is involved in developing both in vitro and in vivo approaches for understanding the role of lysosomal function in the pathophysiology of cellular aging and...

The far more nuanced and precise data produced by single cell analyses will allow for better understanding of pancreatic islet function and dysfunction at the cellular level.

Dominant mutations in the MORC2 gene have recently been shown to cause axonal Charcot - Marie - Tooth (CMT) disease, but the cellular function of MORC2 is poorly understood.

To understand the mechanism (s) underlying the MELK function in BBC cells, we examined how inducible shRNA - mediated MELK depletion affects various cellular processes.

To accurately assess thyroid function, it must be understood that deiodinase enzymes are essential control points of cellular thyroid activity that determine intracellular activation and deactivation of thyroid hormones.

Maybe there's other reasons we don't understand and the cholesterol is just something we can measure and there's some other cellular function that gives them a slight survival advantage that is unrelated specifically to cholesterol but they seem to have perfectly fine sexual hormone function, vitamin D function.