Sentences with phrase «understanding cellular mechanisms»

Everon is a leader in understanding cellular mechanisms of aging and translating this knowledge into development of anti-aging therapies.

These results mark another step toward understanding the cellular mechanisms that enable a bacterial protein - in this case, the cytochrome MtrC - to transfer electrons to minerals in soil, sediment, and subsurface materials.

Research: Neurophysiology, with a focus on understanding the cellular mechanisms that enable animals to generate flexible rhythmic movements

The results of the research open new possibilities for understanding the cellular mechanisms responsible for genome instability and for being able to explore new therapeutic approaches.

«This kind of study allows us to start understanding the cellular mechanisms» behind the brain damage, she says.

«The goal of our work is to understand the cellular mechanisms responsible for beta cell destruction so that we can identify the best targets for beta cell protection,» Costes said.

«It's critical to understand the cellular mechanism by which the liver renews itself.

«This could be the basis to understand the cellular mechanism» of sleep, she says, and ultimately why humans need their nightly zzzzs.

Not exact matches

In their years - long quest to understand the cellular and genetic mechanisms that may trigger SUDEP, Noebels and his colleagues have studied the genes that are involved in the heart beat.

A research team from Wayne State University recently published a paper in the Journal of Clinical Investigation that provides a paradigm shift in the understanding of cellular and molecular mechanisms underlying diabetic peripheral neuropathy (DPN) and wound healing in the treatment of corneal and skin diabetic ulcers.

«While rodents are essential for understanding mechanisms at a cellular or molecular level, at a higher cognitive level, the best you could do was a sort of rough analogy.

«We are trying to understand the causes of aging by linking the mechanisms that control the oxidation of proteins at the cellular level with the mechanisms that determine the lifespan of the whole organism,» Apfeld says.

Valproic acid is widely used to treat various types of seizure disorders, but to this point, the cellular mechanism affected by its anticonvulsant properties were not well understood.

«We reasoned that if we could identify microRNAs that regulate the progression of colorectal cancer, we could use them as molecular probes to better understand the molecular and cellular mechanisms that govern liver colonization,» says Tavazoie, who is Leon Hess Associate Professor and head of the Elizabeth and Vincent Meyer Laboratory of Systems Cancer Biology.

Yet the molecular and cellular mechanisms that underlie these problems are still only partly understood.

Dr. Monteggia's lab focuses on the molecular and cellular bases of neural plasticity, the fundamental property of nerve cells to alter their communication, as they pertains to neuropsychiatric disorders, as well as understanding the mechanisms underlying antidepressant efficacy.

For example, Perry says, «There is a great deal of interest in people who understand the basic mechanisms of cellular biology, genetics, and proteins.»

Understanding mechanisms of vocal learning at a cellular level is a huge step toward being able to someday address the biological issues behind the behavioral issues,» said Sarah Bottjer, senior author of an article on the research that appears in the Journal of Neuroscience on Sept. 4.

For instance, this device can help us understand the mechanisms by which various inputs and treatments alter plant growth at the cellular level.

Dr. Maria Iribarne, first author of this study, commented: «The gosh mutant is a good model for understanding the molecular and cellular mechanism of cone cell death and the pathological process of human LCA.

To gain an understanding of the mechanism that connects low mtDNA levels with a cellular change that leads to cancer and metastasis, Guha, Avadhani and their colleagues set up two systems by which they could purposefully reduce the amount of mtDNA in a cell.

«While it is well - established that obesity generates cellular and molecular stress leading to abnormal functioning of many cellular processes, the mechanisms remain incompletely understood,» said senior author Gökhan S. Hotamisligil, chair of the Department of Genetics and Complex Diseases and the Sabri Ülker Center for Nutrient, Genetic, and Metabolic Research.

The findings add a new level of complexity to our understanding of the cellular mechanisms of taste perception, which may ultimately lend insight into individual differences in food preferences and dietary choices.

Identifying these functional couplings is an important step in the understanding of higher level mechanisms performed by complex cellular processes.

It supports proposals that use different technologies to build up knowledge of functional mechanisms and intracellular dynamics with atomic structure information and integrate these into an understanding of cellular processes in the native environment and in real time.

At Weizmann, Dr. Spiegel will be establishing his own independent research group which will attempt to identify the molecular and cellular mechanisms through which experience alters the structure and function of neural circuits in the brain in behaviorally relevant ways and to understand how these processes, when they go awry, might give rise to psychiatric disorders.

Studying coral calcification with antagonists can provide further information and knowledge to better understand the role and function of genes that participate in the cellular control mechanism, and in the coral organic matrix.

In recent years, our laboratory has focused much effort on understanding the molecular and cellular mechanisms regulating muscle cell fusion.

We are interested in understanding the molecular mechanisms of proteins involved in cellular signalling, especially protein kinases.

Work in our group is aimed to understand the cellular, molecular and genetic mechanisms that control the establishment and maintenance of epithelial cell polarity.

The question of how cellular behavior is controlled is at the center of stem cell biology, and understanding the mechanisms of cell fate regulation is key for treating diseases that occur upon dysregulation, such as cancer or diabetes.

She has pioneered the intergration of large - scale genome and transcriptome sequencing data to understand how genetic variation affects gene expression, providing insight to cellular mechanisms underlying genetic risk for disease.

The Kaufman lab is focused on understanding the fundamental mechanisms that regulate protein folding and the cellular responses to the accumulation of unfolded proteins within the Endoplasmic Reticulum (ER).

Understanding the underlying mechanisms allows identifying putative sites for pharmacological intervention and opens the prospect of engineering artificial molecular switches derived from the highly efficient systems that have evolved for cellular signal transduction.

Our ultimate goals in this activity include (1) a better understanding of the molecular mechanisms governing cellular processes and especially those involved in certain kinds of diseases such as cancer and (2) the development of computational tools that can be used for diagnostic / prognostic purposes based on genomic data.

Scott Henderson, who has been directing microscopy core facilities for nearly 25 years, loves to talk about how such facilities help scientists explore essential cellular functions and gain a better understanding of the mechanisms associated with disease.

The goal of our research is to better understand the cellular and molecular mechanisms involved in neuronal and synaptic dysfunctions characterizing neuropsychiatric diseases.

My research interest is to understand the neuroendocrine mechanisms that regulate reproductive function and behaviors at molecular, cellular, and systemic levels.

As we gain a deeper understanding of the cellular regulation mechanisms of Tau function, we will shed more light on the complex role of Tau in the aetiopathogenesis of neurodegeneration.

It is widely believed that cellular senescence is a tumor suppressor mechanism; however, it has not been understood why it is advantageous for organisms to retain mutant cells is a postmitotic state rather than simply eliminating them by apoptosis.

The genomic era as greatly advanced our understanding of cellular processes and disease mechanisms.

This understanding of the cellular and molecular mechanism of recovery from acute promyelocytic leukaemia opens prospects for activating this same PML / p53 pathway in other types of cancers.

These isogenic cell lines can be used not only to understand the cellular consequences of disease mutations, but also to perform high throughput genetic and pharmacological screens to both understand the underlying pathological mechanisms and to develop novel therapeutic agents to prevent or treat such diseases.

Therefore, the identification of cellular and molecular mechanisms underlying neuron - astrocyte communication will help to a better understanding of the mechanisms of brain phsyiology as well as to appropriately identify cellular targets to direct therapeutic approaches for the future treatment of several brain diseases.

However, the molecular and cellular mechanisms controlling interactions within the metaorganisms are poorly understood and many key interactions between the associated organisms remain unknown.

The single - cell perspective has helped to better understand gene regulation and regulatory networks during exit from pluripotency, cell - fate determination as well as molecular mechanisms driving cellular reprogramming of somatic cells to induced pluripotent stage.

To understand the mechanism (s) underlying the MELK function in BBC cells, we examined how inducible shRNA - mediated MELK depletion affects various cellular processes.

Our laboratory uses in vivo and in vitro techniques to understand the physiological, cellular and molecular mechanism of metabolic therapies.

Molecular medicine and molecular biochemistry provide the what and how these changes, especially deleterious ones may be treated, cured, suppressed, or understood in context with other gene regulatory mechanisms and transcription and translation coupled systems within the actual cellular environment.