Sentences with phrase «understanding gene regulation»

Our laboratory focuses on understanding gene regulation in the cardiovascular system, skeletal muscle, and other metabolic tissues, with the ultimate goal of finding novel therapeutic strategies to prevent and treat cardio - metabolic and - myopathic diseases.

«Quantum machine shows promise for biological research: In first quantum machine learning study with biological data, researchers leverage D - Wave to understand gene regulation.»

The research that led to these findings is part of a larger effort to better understand gene regulation and expression, carried out by the GTEx Consortium, a National Institutes of Health - funded group that includes researchers from around 80 institutions founded in 2010.

To understand gene regulation, Panne works on a cell - free model of the human interferon beta response to viral infection.

The single - cell perspective has helped to better understand gene regulation and regulatory networks during exit from pluripotency, cell - fate determination as well as molecular mechanisms driving cellular reprogramming of somatic cells to induced pluripotent stage.

Not exact matches

This finding by Whitehead Institute scientists challenges current understandings of gene regulation via DNA methylation, from development through adulthood.

This research tool can be used to better understand the function of histone proteins, which play critical roles in the regulation of gene expression in animals and plants.

The quantum machine was also able to generate conclusions that were consistent with a biologist's current understanding of gene regulation.

However, to make use of that information required an understanding of gene expression and regulation, areas in which institute members made a conscious decision to invest and that became its strengths.

Thus, the discovery of DNA methylation in early diverging fungi helps the research community better understand regulation of genes that encode the parts for bio-based economy and bioenergy applications.»

Plants perform these regulations mainly by regulating nuclear gene expression and multiple intracellular signaling pathways have been shown to play a role in the genomic response of plants to stress, but the processes are not well understood.

At the nucleic acid level, understanding the precise regulation of genes through analysis of gene expression data will be of utmost importance.

While the study represents a strong start for understanding how eQTLs affect gene regulation and expression, Engelhardt pointed out that she and her colleagues still do not have enough samples to understand trans - eQTLs as deeply as they would like.

Building on years of mouse and gene regulation studies, they have developed a resource that can help scientists better understand how similarities and differences between mice and humans are written in their genomes.

She leads a multidisciplinary team integrating computational and experimental approaches to develop an understanding of gene regulation in immune cells.

The publication of the latest Canine genome build and annotation, CanFam3.1 provides an opportunity to enhance our understanding of gene regulation across tissues in the dog model system.

«Using this approach, we will eventually be able to do the same thing you would do in English class — pick up a book of haiku or Shakespeare and understand that «this is a love poem,» or «this is an elegy,» because we'll understand how the words — the DNA elements — are used in different contexts to convey different meanings on the regulation of genes,» Arnosti said.

Targeted gene therapies, however, had to wait for (1) the identification of the genes to target, (2) the cloning and / or sequencing of the relevant genes and in some cases, the specific disease - causing variant, (3) a full understanding of the normal gene function and regulation, and (4) the development of efficient ways to deliver genes to the relevant tissues at therapeutic levels.

Many miRNA genes, therefore, lack annotated features such as a promoter or splice sites, hindering progress in understanding their transcriptional and post-transcriptional regulation.

Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the regulation of gene expression and modulation of the host immune response during ¿ - herpesviral infection.

These results are a huge step towards understanding the basic molecular mechanism behind gene regulation.»

He has made fundamental contributions to our understanding of vertebrate developmental biology and microRNA - based gene regulation using the model organism zebrafish.

«The knowledge gained will help us understand many human disorders caused by malfunctions of gene regulation, a major goal of the NIH and of our new Institute for Genomics and Systems Biology in Chicago» White said.

To understand and analyze the regulation of gene expression patterns, quantitative RNA sequencing is used.

Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the regulation of gene expression and modulation of the host immune response during gammaherpesvirus infection.

Professor Segal's research has two major directions 1) Gene regulation — using quantitative and computational models to understand how DNA sequence variation among human individuals generates phenotypic diversity 2) Microbiome and Nutrition — understanding how the microbial composition of individuals affect their physiology and health.

Now that scientists understand how these genes control the heart, they can begin to piece together how heart disease disrupts this regulation.

RNA - based gene regulation is revealing itself as key to understanding cellular function, organismal development and homeostasis.

Several functions vary among the members of this group of bacteria, such as metabolism of nitrogen, respiration, cell wall and capsule, stress response, secondary metabolite biosynthesis, regulation and cell signaling; this variation in gene functions could help us understand the ability of colonization and adaptability of these rhizosphere - colonizing bacteria.

Throughout his postdoctoral years, at Memorial Sloane - Kettering Cancer Center, and into his tenure at the University of Michigan, Dr. Al - Hashimi remained steadfast in his determination to solve the problem of how to visualize atomic motion, «to obtain a deeper understanding of gene regulation and to build new technologies for drug discovery and biotechnology.»

A physicist turned computational scientist, Graber comes to the MDI Biological Laboratory from The Jackson Laboratory, also located in Bar Harbor, where he focused on computational approaches to understanding post-transcriptional gene regulation and interactions, while also working intensively to process, analyze and interpret the genome - scale data sets generated within the Patient Derived Xenograft (PDX) cancer study program.

We study learning and memory at the genetic level to understand the structure, regulation, evolution and biological function of genes that are required for normal learning and memory.

Research Focus: I dedicate my time and effort to develop high - throughput sequencing technologies such as single cell transcriptomic, ChIP - Seq, ChIA - PET, and many more... The scientific rational is to understand better and with a different angle, the mechanisms of epigenetic regulation of gene expression in (rare) immune cells, pathologically relevant in many diseases such as asthma, SLE, tuberculosis...

We have a longstanding interest in understanding gene expression regulation, and in our wetlab at the Sanger Institute use mouse T helper cells as a model of cell differentiation.

Methylation of mammalian DNA and histone residues are known to regulate transcription, and the discovery of demethylases that remove methylation in DNA and histones provide a basis for the understanding of dynamic regulation of mammalian gene expression.

- The work, published in Nature Genetics, represents an important advance in our understanding of gene regulation and reveals a new layer of complexity that needs to be studied to properly interpret genomics and gene expression in the future.

Major areas of activity in our lab include 1) identification and characterization of Sgenes, 2) genomic analyses to identify the diversity of TAL effectors in pathogen populations and understand their evolution, and 3) structural and biochemical studies to better harness the unique properties of these proteins for applications such as targeted gene regulation and genome editing.

The current findings could provide important clues to determine the culture conditions for promoting the differentiation of primate ES cells into mature gametes, and to understand molecular mechanisms of primate gametogenesis including the timing of germ cell induction, the regulation of germ cell gene expression, and the response to growth factors for germ cell differentiation.

Her scientific expertise lies in understanding the epigenetic basis of gene regulation during embryonic development and disease ontology.

His group work on understanding the regulation of gene expression, especially at the single - cell level where he has pioneered analytical approaches.

To uncover molecular processes in individual cells and to understand the full complexity of biological systems, our lab applies and develops novel microscopy and genomics based techniques to study the regulation of gene - expression in single cells.

A basic understanding on the set of genes and gene networks responsible from directly regulating lifespan and the mechanisms used in this regulation is also missing.

The focus of the Mar lab is to understand how variability in gene expression contributes to the regulation of cellular phenotypes.

High fibre diets also contain various fatty acids such as the short chain fatty acids (SCFA) and the understanding of synergistic effects of SCFA and phytosterols in glucose regulation and cholesterol homeostasisis important to our understanding of diet, lifestyle and drugs in relation to peripheral amyloidosis and gene expression

High fibre diets also contain various fatty acids such as the short chain fatty acids (SCFA) and the understanding of synergistic effects of SCFA and phytosterols in glucose regulation and cholesterol homeostasisis important to our understanding of diet, lifestyle and drugs in relation to peripheral amyloidosis and gene expression that play an early role in the development of AD.

We want to understand this observation through the investigation of gene regulation in the context of the epigenetic landscape.

Respiratory sinus arrhythmia in the fourth decade of life depends on birth weight and the DRD4 gene: Implications for understanding the development of emotion regulation.