Sentences with phrase «understanding of cancer biology»
We find out how advances are deepening our understanding of cancer biology and resistance processes, which will lead to new clinical applications such as non-invasive biomarkers and drug development.
https://www.technologynetworks.com/
Dr Iain Foulkes, Cancer Research Technology's CEO, said: «This bold and exciting collaboration between one of industry's leading innovators, Celgene, and CRT is part of our theme - based drug discovery approach and helps leverage our understanding of cancer biology and the needs of patients to drive the most promising discoveries into the clinic.
Studying rare familial syndromes can have broad implications to our understanding of cancer biology.
He believes that as our understanding of cancer biology improves, we will use cancer tests more judiciously — and treat less.
Strahl said, «We think this work will lead to a greater understanding of cancer biology, and open the door to future therapeutic approaches for patients in need of better treatment options.»
«Thanks to a deeper understanding of cancer biology, we have a potential new targeted therapy for multiple myeloma, and can better tailor treatment for kids with Wilms tumor.
Not exact matches
We're also making progress on our liquid biopsy program since our last update, including the recently announced collaboration with Memorial Sloan Kettering Cancer Center, which is focused on furthering the basic understanding of the biology of circulating tumor DNA, or ctDNA, in different cancer Cancer Center, which is focused on furthering the basic understanding of the biology of circulating tumor DNA, or ctDNA, in different cancer cancer types.
Improved understanding of the biology of cancer cells has led to the development of biological agents that mimic some of the natural signals that the body uses to regulate growth.
One of the key questions in cancer biology is to understand the mechanisms that control tumor heterogeneity and to determine to which extend tumor heterogeneity influences clinical outcome.
In addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapies.
«Everything we talked about was about research directly on the embryo,» for example, to improve on infertility treatment or better understand cancer biology, says R. Alta Charo, a law professor and bioethicist at the University of Wisconsin Law School who was a member of the NIH Human Embryo Research Panel in the mid-1990s, which considered how embryos might be used in research.
Outcomes of children and young adults with cancer have improved, primarily due to enhanced understanding of tumor biology and due to the clinical application of biological discoveries through multicenter clinical trials.
GIS's DNA analysistechnique has allowed the researchers to further study the biology of Opisthorchis viverrini to understand the cause and the eventual development of treatments for bile duct cancer, a condition caused by the parasite.
Co-author Dr. David Hinds from 23andMe said: «While the genetics of hair colour is an interesting problem in itself, we hope that better understanding of the biology of melanin pigmentation will be applicable to studies of diseases that interact with pigmentation, such as skin cancer or vitiligo.»
If we want to change the death rate, we need to increase the investment in understanding the biology of pancreatic cancer and identifying novel treatment strategies,» said co-author and pancreatic cancer surgeon Dr. Michael Choti, Chairman of Surgery, who holds the Hall and Mary Lucile Shannon Distinguished Chair in Surgery.
The investigators caution that application of their findings to the treatment of pancreatic cancer must await further understanding of the complicated genetics and biology of metastases.
It is vital that we get a better understanding of the biology of DCIS as well as what makes it return in some women and become invasive breast cancer.
«Students used to say, «I want to understand basic biology,»» says Tom Curran, a former president of the American Association of Cancer Research.
Most of the research into breast cancer has focused on primary breast cancer, and there is little understanding of the biology underpinning breast cancer that has spread to other parts of the body, known as metastatic cancer.
In fact, how the protein becomes part of cancer cell biology isn't well understood.
This led to development of newer technology, called single cell sequencing (SCS), that has had a major impact in many areas of biology, including cancer research, neurobiology, microbiology, and immunology, and has greatly improved understanding of certain tumor characteristics in cancer.
By understanding the underlying biology of aging, she notes, it may be possible to develop drugs in the future that will promote healthy aging and delay age - related diseases such as some cancers, arthritis, diabetes, high blood pressure and heart disease.
Petris says that understanding the roles of copper in biology may have far - reaching health implications for the general population because copper underpins many facets of biology, including the growth of cancer tumors and the formation of toxic proteins in Alzheimer's disease.
We really don't understand the basic biology of prostate cancer and that makes it very difficult to find targeted therapies,» Liu says.
«The findings advance our understanding of the role of lncRNAs in cancer biology and, importantly, broaden the opportunity to use lncRNAs as biomarkers to detect prostate cancer.»
New understanding of the biology behind a successful cancer therapy may lead to a drug that can treat an array of solid tumors
«This will help us better understand the biology of cancer, guide therapeutic decisions and develop novel therapies.»
On Capitol Hill last week, Weinberg, an expert in the molecular biology of cancer, pointed out to the Congressional Biomedical Research Caucus that the major advances in understanding human cancer genetics had come, not from studying breast tissue, but from studying cow warts, worm vulvas, fruitfly retinas, and a chicken virus.
Focused both on discovery and on mentoring future generations of researchers, Salk scientists make groundbreaking contributions to our understanding of cancer, aging, Alzheimer's, diabetes and infectious diseases by studying neuroscience, genetics, cell and plant biology and related disciplines.
The authors conclude that their six hallmarks — sustained proliferative signaling, evading growth suppression, resisting cell death, replicative immortality, induction of angiogenesis, and invasion / metastasis — continue to provide a useful conceptual framework for understanding the biology of cancer.
«The exciting research carried out by Dr Michael Allen and Professor Louise Jones makes significant steps forward in our understanding of the biology of DCIS (ductal carcinoma in situ) and its progression to invasive cancer.
Prostate Cancer Laboratory: The laboratory's research focus is on understanding the biology of abnormal prostate growth.
CSHL is a private, non-profit research and education institution dedicated to exploring molecular biology and genetics in order to advance the understanding and ability to diagnose and treat cancers, neurological diseases, and other causes of human suffering.
The characterization of the genetic alterations observed in neuroblastoma led to the identification of major players of neuroblastoma oncogenesis that has considerably improved our understanding of the biology of this pediatric cancer.
Through understanding the biology of cancer cells and their interaction with the immune system we are able to discover and trial novel therapies to induce the immune system to detect and fight cancer cells.
For understanding the biology of gene - gene, gene - drug and gene - microenvironment interactions, a considerably broader range of in vitro and in vivo model systems is required — we are generating 1,000 organoid cultures from human cancers, characterising their genomes, functional dependencies and drug response, and we are expanding our in vivo models to study the interface between cancer and the immune system and microenvironment.
The question of how cellular behavior is controlled is at the center of stem cell biology, and understanding the mechanisms of cell fate regulation is key for treating diseases that occur upon dysregulation, such as cancer or diabetes.
«Thanks to improvements in the understanding of AML biology, a multiplicity of so - called targeted therapies and therapies based on differential pathophysiology of leukemic stem cells compared with normal counterparts have emerged,» noted Richard M. Stone, MD, clinical director of the Adult Leukemia Program at Dana - Farber Cancer Institute in Boston, and colleagues, writing in a review for the ASCO 2017 Educational Book.
«These findings show that our cancer model will not only allow us to start understanding the biology of glioblastoma but will also allow us to answer many questions surrounding cancer stem cells,» says Verma.
Altieri and his team are currently focused on three programs to understand the biology of survivin with respect to cell cycle progression, in particular, mitosis, cell survival and the cellular stress response and how exploiting these pathways may provide new cancer therapeutics.
While their work has been critical to advancing our understanding of cancer, we do ourselves a disservice to limit the scope of research to biology alone.
More recently, we have learned that it is critical to understand the biology of cancer plasticity to identify the mechanisms that allow tumours to resist or escape immune control.
This may bring us closer to understanding the underlying biology of a very common form of cancer, and KRT5 in particular may point us to new pathways for developing new drugs or skin care products.
«When we think about radiation therapy, it is high technology, but the complexity of cancer requires that we have a better understanding of the biology,» says Marikki Laiho, the Willard and Lillian Hackerman Professor of Radiation Oncology and Vice Chair of Research for the Department of Radiation Oncology and Molecular Radiation Sciences.
Research in my laboratory is dedicated to understanding the molecular biology of cancer metastasis and translating this knowledge to clinical application.
Genentech has long been a leader in understanding and advancing the fields of cancer biology, cancer immunology and oncology drug discovery.
Investigations of this phenomenon may provide unique access to understanding genomic disorders, structural variant mutagenesis, human evolution, and cancer biology.
«Visualizing how cancer cells interact with a tumor microenvironment that accurately reflects the complex biology of ovarian cancer should help us understand the mechanisms underlying metastatic progression as well as identify new therapeutics that can inhibit this process,» said clinical gynecologic oncologist Ernst Lengyel, MD, PhD, senior author of the study and a professor of obstetrics and gynecology at the University of Chicago.
However, with our increasing understanding of lung cancer biology has come the advent of targeted therapies to combat this devastating disease.
They are, as such, the first dividend of a profound understanding of the biology of cancer rather than scatter - gun molecular test activity.