A major clue to
understanding schizophrenia came with the development of phencyclidine (PCP) in 1956.
The study also reinforces the potential value of brain scans for identifying and
understanding schizophrenia in individual patients, for finding promising new therapeutic approaches, and for helping clinicians track a patient's progress during therapy.
Not exact matches
Professor Jianfeng Feng commented that new technology has made it possible to conduct this trail - blazing study: «human intelligence is a widely and hotly debated topic and only recently have advanced brain imaging techniques, such as those used in our current study, given us the opportunity to gain sufficient insights to resolve this and inform developments in artificial intelligence, as well as help establish the basis for
understanding and diagnosis of debilitating human mental disorders such as
schizophrenia and depression.»
Bierut: I am trained as a psychiatrist, so I have my medical degree and specialized training in psychiatric disorders such as alcoholism, depression,
schizophrenia, and I also have training in genetics so to
understand how illnesses are transmitted through families, and so we are trying to look at how mental illnesses and addictions are transmitted in families and
understand the underlying genetic causes of them.
Using iPSCs, researchers developed a novel cellular disease model to probe the neurobiological causes of
schizophrenia, which are not well
understood (ChangHui Pak, abstract 032.29, see attached summary).
However, recent laboratory studies have shown that hedonic experience is actually intact in people with
schizophrenia, calling for new approaches to better
understand these motivational deficits.
Standing in the way of a definitive answer was a researcher's Catch - 22: Many experiments designed to
understand cognitive disorders such as
schizophrenia or Alzheimer's require a participant's conscious attention - yet these disorders interfere with attention.
Researchers hope that figuring out handedness will help them better
understand brain organization and the causes of conditions such as dyslexia, stuttering, autism and
schizophrenia.
Advances in our
understanding of the biological pathways and mechanisms involved will help uncover new targets for treatment, which could one day translate into better, more personalised care for people living with
schizophrenia.»
The results of this study not only advance science's
understanding of the links between genes, the brain and behavior, but may lead to new insight into such disorders as autism, Down syndrome and
schizophrenia.
In addition to running his own lab, he directs the Applied Neurotherapeutic Research Group, a collaborative research initiative funded jointly by SFI and Wyeth, to
understand the molecular underpinnings of changes in behavior and to identify new drug targets for diseases such as
schizophrenia.
«Determining the role of ZNF804A is the first step in
understanding how
schizophrenia - associated genes contribute to abnormal brain development,» said Mao.
Understanding the function of this gene — described this month in journal Molecular Psychiatry — could lead to more effective treatments for
schizophrenia.
We may soon
understand the exact links between genes and
schizophrenia, genes and fear, even genes and love.
A bearded, professorial figure, McFarlane has long been on the leading edge of advancements in the psychiatric
understanding of
schizophrenia.
This result is significant for the
understanding of neurobiological factors contributing to
schizophrenia.
A neuroscientist at Rutgers University - Newark says the human brain operates much the same whether active or at rest — a finding that could provide a better
understanding of
schizophrenia, bipolar disorder and other serious mental health conditions that afflict an estimated 13.6 million Americans.
Researchers are far from a complete
understanding of what causes
schizophrenia and how it affects the brain, and some psychiatrists contend that treating a patient for a disease not yet manifest is a clear violation of a basic tenet of medicine: to do no harm.
Precisely how such stress can lead to a psychotic break isn't
understood, but scientists do know
schizophrenia has complex genetic and environmental components.
«We knew this gene's alteration likely contributed to
schizophrenia and we wanted to better
understand how,» said Mei, chairman of the Department of Neuroscience and Regenerative Medicine at the Medical College of Georgia at Augusta University, Georgia Research Alliance Eminent Scholar in Neuroscience and a corresponding author of the study in the journal PNAS.
Could they help people with depression,
schizophrenia or alcoholism
understand their illness?
Christianson said his team uses neuroscience techniques «to investigate the biological basis for social cognition with the hope that we can better
understand and treat people with conditions marked by aberrant social cognition such as autism or
schizophrenia.»
The surprise finding could have implications for our
understanding of
schizophrenia, a psychological disorder which often appears in early adulthood.
This helps us in everyday life, but it also holds great potential when trying to
understand why people with autism and
schizophrenia have difficulties with social interaction.
A new study from Aarhus University, Denmark, helps us
understand why people with autism and
schizophrenia have difficulties with social interaction.
The findings suggest a new avenue of exploration for
understanding the origin of disorders such as autism and
schizophrenia.
The root cause of psychiatric illnesses such as bipolar disorder, major depressive disorder
schizophrenia, autism and ADHD is not fully
understood.
One of the most striking contrasts between autism and
schizophrenia is how they affect the ability to
understand others.
Yet experts have lately come to
understand that the prognosis for patients with
schizophrenia is not uniformly dire.
Clearly, we have made considerable progress in our
understanding of
schizophrenia's course and are more optimistic than we have ever been about the future of those afflicted.
Only half of identical twins whose siblings have
schizophrenia develop the disease, making it critical to better
understand how known risk factors such as urban environments and complications at birth contribute, he says.
These structures are not sole determinants of
schizophrenia or autism, Bearden said, but rather, more dots in the connect - the - dots puzzle of
understanding these disorders.
It makes more sense to study the genesis of hallucinations, for example, than to expect to
understand the diverse causes of
schizophrenia, which does not present in one uniform way.
«These results are important for
understanding the onset of illness in conditions such as
schizophrenia, depression or ADHD, which mostly occur at the threshold of adulthood.
So if we can
understand synapses a little bit better, we'll be able to
understand the normal function of the brain, how it processes information, how it learns, and what goes wrong when you have, say,
schizophrenia.»
Yoshizawa, now an evolutionary developmental biologist at the University of Hawaii, Manoa, has been testing whether these fish might be useful in
understanding the genetic basis of
schizophrenia or autism.
The drug — a mood stabilizer called valproate — is commonly prescribed to treat bipolar disorder and
schizophrenia, though its mechanism of action is poorly
understood and only some patients respond to the treatment.
Clearly, more research is necessary, but this new study adds to the growing and substantial effort to
understand how the gene variants that contribute to the development of
schizophrenia give rise to the cognitive disability commonly associated with it.
With further research into how these genes affect the brain, it could become possible to
understand how genes linked to
schizophrenia affect people's cognitive function,» said McIntosh.
By
understanding how neuregulin 3 acts in the brain, researchers could conceivably design drugs to restore its function during
schizophrenia.
«They might not arise from the same brain areas, but these observations are of importance in efforts to
understand hallucinations that commonly occur in psychiatric disorders such as
schizophrenia,» says Matcheri Keshavan, a psychiatrist at Harvard Medical School.
Because despite the advances in
understanding autism and
schizophrenia, treatment is limited and difficult, and a cure remains elusive.
The technique may be able to help neurologists
understand the progression of diseases such as Alzheimer's,
schizophrenia and multiple sclerosis.
Although it isn't possible to make true mouse models of
schizophrenia, the study is «elegant» and an «important new building block» toward a better
understanding of the MD's role in
schizophrenia's cognitive deficits, says psychiatrist John Krystal of Yale University.
The prototype is already helping doctors and relatives of people with
schizophrenia get a better
understanding of the disorder.
He now sees HERV - W as key to
understanding many cases of both MS and
schizophrenia.
Over the last decade, important contributions to our
understanding of
schizophrenia have come from two different types of studies.
The evidence from MRI scans suggests that such Neanderthal - derived genetic variation may affect the way our brains work today — and may hold clues to
understanding deficits seen in
schizophrenia and autism - related disorders, say the researchers.
«The ultimate goal of the study was to see if evolution may help provide additional insights into the genetic architecture of
schizophrenia so that we can better
understand and diagnose the disease,» Dudley explains.
«The approach may be extended to additional complex disorders and diseases for which we don't
understand the underlying biology but do have drugs that may have some beneficial actions, such as depression, anxiety,
schizophrenia and others in need of more effective therapies.