Abatacept, when added to the standard drug regimen used to prevent GvHD, reduced the occurrence of acute, grade III - IV GvHD from 32 to 3 percent in pediatric and adult patients who underwent mismatched
unrelated donor stem cell transplants to treat advanced cancer and other blood disorders.
Another study is testing whether
unrelated donor stem cell transplant can provide better long - term outcomes than traditional immunosuppressive therapy (IST) for children with severe aplastic anemia.
Not exact matches
Ildstad and her colleagues report that five of eight people who underwent the treatment were able to stop all immunosuppressive therapy within a year after their kidney and
stem -
cell transplants, four of which came from
unrelated donors.
Concerned that the drug by itself might not keep his aggressive cancer at bay, Wartman opted for a second
transplant — this time with
stem cells isolated from peripheral blood from an
unrelated donor.
Patients receive one of two types of
stem cell - based
transplants: autologous, in which a patient donates and receives back his / her own
stem cells; or allogeneic, in which bone marrow - derived
stem cells come from a related or
unrelated donor whose human leukocyte antigens (HLA) are genetically matched with those of a patient.