The Skin Cancer Foundation says melanoma develops when
unrepaired DNA damage to skin cells triggers mutations.
«However, for the whole organism, adaptation is often dangerous, as
the unrepaired DNA may lead to diseases such as cancer,» points out Dr. Luke.
Not exact matches
Left
unrepaired, these
DNA lesions could lead to induction of senescence, cell death or mutations, which could be responsible for the development of cancer, neurodegeneration and several other diseases.
Despite the efficiency of
DNA repair mechanisms, some
DNA damage is left
unrepaired leading to the gradual accumulation of
DNA lesions in cells.
Mutations or deficiencies in these genes can cause
DNA to go
unrepaired, which increases the chance of developing cancer.
Oxidative stresses induced by free radicals cause
DNA damage, which, when left
unrepaired, can lead to base mutation, single and double strand breaks,
DNA cross-linking, and chromosomal breakage and rearrangement.