Sentences with phrase «unrepaired leading»
Despite the efficiency of DNA repair mechanisms, some DNA damage is left unrepaired leading to the gradual accumulation of DNA lesions in cells.
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«However, for the whole organism, adaptation is often dangerous, as the unrepaired DNA may lead to diseases such as cancer,» points out Dr. Luke.
Left unrepaired, these DNA lesions could lead to induction of senescence, cell death or mutations, which could be responsible for the development of cancer, neurodegeneration and several other diseases.
Oxidative stresses induced by free radicals cause DNA damage, which, when left unrepaired, can lead to base mutation, single and double strand breaks, DNA cross-linking, and chromosomal breakage and rearrangement.