Sentences with phrase «untreated mice»

Researchers needed more sound to spark brain activity in untreated mice compared with treated mice, the team found.

The hair cells of untreated mice, in contrast, looked damaged and sparse.

These mice did not perform significantly differently from untreated mice in many tests of learning and memory, but did improve their memory of places where they had previously received mild electrical shocks.

The vaccinated animals lived almost twice as long, and, in one trial, had about one - fourth as many parasites as untreated mice.

Untreated mice died after 83 days on average.

Aged mice given modified TFAM showed improvements in memory and exercise performance compared with untreated mice.

They found the scarred corneas of mice healed and became clear again within four weeks of treatment, while those of untreated mice remained clouded.

Treated mice had more muscle mass in their hind legs than untreated mice did.

Moreover, the researchers report, lithium chloride - treated mice were much less likely to show the 25 percent drop in memory and cognitive test scores seen in untreated mice given the same amount of alcohol.

Infected, untreated mice showed clear signs of sickness ∼ 4 — 5 d after infection and perished by day 8 — 9.

In additional tests, the scientists found they could restore the norovirus infections by transplanting fecal material from untreated mice into mice that earlier had been treated with the antibiotics.

«The treated mice ran 1600 metres in 2 hours, compared with 800 metres for untreated mice,» Auwerx says (Cell, DOI: 10.1016 / j.cell.2011.10.017).

The study also showed six months after an injury, mice treated with ECM showed signs of new muscle growth while untreated mice appeared to form typical scars.

Interestingly, Xiong et al. further showed that the GDF15 regimen altered food preferences in mice — leading the animals to opt for lower calorie chow when offered a choice between standard food and an extra-rich condensed - milk diet (untreated mice gorged themselves on the high - calorie eats).

Accompanying these abrogated neuroinflammatory changes in the brain, the levels of multiple anti-inflammatory cytokines were elevated in treated - vs. untreated mice.

When exposed to UV rays, the mice with dark pigment had less DNA damage and sunburn, as well as fewer skin tumors, compared with untreated mice (SN: 9/23/06, p. 196).

Villeda emphasized that the effects on learning observed in the B2M - administration experiments were reversible: 30 days after the B2M injections, the treated mice performed as well on tests as untreated mice, indicating that B2M - induced cognitive decline in humans could potentially be treated with targeted drugs.

Upon IL - 23 stimulation, ILCs isolated from untreated mice had a greater percentage of cells expressing IL - 22 than lethal toxin treated mice (Fig 6C).

Alzheimer's mice that received AF267B, they found, performed significantly better on this test than untreated mice did.

Among the study's key findings was that mice given lithium chloride after alcohol consumption and mice that never consumed alcohol had the same duration of undisrupted sleep of about 10 hours per day, while untreated mice given alcohol woke up as many as 50 times per hour.

Infected, untreated mice showed clear signs of sickness around day 4 — 5 after infection and perished by day 8 — 9.

They gave the mice oral doses of an inhibitor that blocks CSF1R and found that it could prevent the rise in microglia numbers seen in untreated mice as the disease progressed.

While only 25 percent of untreated mice were alive at 55 days, 90 percent of the mice treated with the galectin - 9 antibody survived.

When B2M was administered to young mice, either via the circulatory system or directly into the brain, the mice performed poorly on tests of learning and memory compared to untreated mice, and neurogenesis was also suppressed in these mice.

Residual tumors, spawned from the remaining cancer cells, were 3.5 times smaller in the treated mice than in untreated mice.

All untreated mice died.

But after the elderly animals were given THC, their performances improved to the point that they resembled those of young, untreated mice.

«Indeed, in a second tumor model of metastatic breast cancer, we demonstrated that mice treated with the EphA2 - targeting paclitaxel conjugate presented nearly no lung metastases, while a large numbers of lesions were observed in both untreated mice and in mice treated with just paclitaxel.»

A few days later, there were on average 90 per cent fewer metastatic tumours in this group than there were in untreated mice, and the average weights of original pancreatic tumours had decreased by 64 per cent.

No improvements were observed in untreated mice.

When the researchers injected myelin - deficient regions in the mice with a drug that prevents destruction of the AXIN2 protein, the mice grew myelin sheaths faster than untreated mice, repairing the damage.

By the time all the untreated mice had died, around 90 per cent of the treated mice were still alive.

Mice who received the modified buckyballs had their symptoms delayed by 10 days and survived 8 to 10 days longer than untreated mice.

In contrast, the untreated mice saw a general decline in pumping efficiency at the end of the same three month period,» he said.

Treating the mice with antibodies against CD4 + T - cells four weeks after experimental heart attacks — to deplete that subset of T - cells — prevented the progressive abnormal enlargement of the left ventricle that leads to heart failure, as compared with untreated mice.

Mice pretreated with these engineered APCs expressed a foreign gene for 50 days after adenovirus infection, more than twice as long as in untreated mice.

They injected both the knockout mice and normal mice with AAV vector and found that 33 % -56 % had liver tumors, compared to 4 % -8 % of untreated mice.

Post mortems showed that brain connections lost in the untreated mice remained healthy, and completely normal protein production had resumed in the treated animals, even though the prions continued to accumulate.

Treated mice formed fewer tumors and showed less angiogenesis, and half survived to day 40, whereas all untreated mice died within 30 days, the group reports in Science.

After 27 days, both the untreated mice and those with the non-FlaB version of S. typhimurium had dozens of metastases.

The researchers demonstrated this by isolating phage from either antibiotic - treated mice or untreated mice, then adding those phage to gut bacteria from untreated mice.

But he points out that although there is a statistical difference between the performance of the treated and untreated mice, that difference is small.

Treated mice retained several times more myelination and oligodendrocytes than untreated mice.

And after 3 weeks, untreated mice in a control group (left) remained bald, while those given tofacitinib or ruxolitinib (right) had hair - covered right sides.