Sentences with phrase «untreated patients»

[21] In the recently presented FLAURA study, in which osimertinib was used in untreated patients with advanced EGFR - mutant NSCLC, the HR for systemic disease control and CNS control similarly favored osimertinib over erlotinib or gefitinib, supporting the preclinical data that showed osimertinib's penetration across the BBB and providing support for using this agent in first - line management of EGFR - mutant patients with brain metastases.

KEYNOTE - 024 investigated the efficacy of pembrolizumab compared to standard of care with platinum - based chemotherapy in untreated patients with advanced NSCLC and high PD - L1 expression (defined as expression in at least 50 % of tumour cells).

Choueiri and colleagues conducted the phase I trial to test the safety and efficacy of this combination in previously untreated patients with RCC.

It is estimated that about 60 % of Ebola infections remain undiagnosed in the community; while 60 - 90 % of untreated patients with Ebola die, supportive medical care could reduce this rate to below 30 %.

«Immunotherapy combination promising for untreated patients with advanced melanoma.»

«Additional studies are needed to assess the effects of those drugs, with larger numbers of treated and untreated patients as well as individuals who do not have Parkinson's.»

Duesberg doesn't see anything wrong with studying untreated patients.

But a late - stage clinical trial called CheckMate - 026 for the drug failed to meet its primary goal of halting cancer progression in advanced, untreated patients whose tumors consisted of at least 5 % PD - L1.

More than twice as many untreated patients died as those who received transfusions.

The infantile onset form of the disease is the most severe, with untreated patients experiencing significant heart and lung failure by the second year of life.

M184V mutations quickly revert to their «un-mutated» state in untreated patients because the mutation limits viral replication; as a result, M184V viruses multiply above all in treated patients, who can can transmit them to other persons.

Researchers in the study evaluated untreated patients with subclinical hypothyroidism along with patients taking a T4 hormone.

However, our effects were similar to those in other quality improvement effectiveness trials.52 Intervention effects were also averaged across the entire quality improvement group (including untreated patients), and patients in the usual care group were free to receive «usual care» treatments, likely attenuating intervention effects.

The median overall survival for previously untreated patients was 18.6 months.

«We were disappointed to see only a modest reduction in the number of untreated patients, which remained unacceptably high,» he said.

Milestones such as head control, rolling, and sitting, are rarely, if ever, achieved in untreated patients in the natural history of Type 1 SMA.3

Because osteocalcin levels in untreated patients with diabetes tend to be low, injections of the protein might alleviate the symptoms of diabetes in humans, an approach Karsenty is testing in mice.

The phenomenon was present in both untreated patients and patients who received a treatment, called tPA, to dissolve the blood clot responsible for their strokes.

The race is on not only to prove that patients are getting better — by comparing patients treated with stem cells with untreated patients in a blinded trial — but also to pinpoint the effects.

On average, untreated patients had two to three times as many immune cells producing GM - CSF as did patients being treated with INF - β, or normal subjects.

One successful compound, named Exel 647, that targets nonsmall - cell lung cancer in previously untreated patients is now in a phase 2 clinical trial.

In the study, researchers from Kansas City VA Medical Centre in Kansas City, USA, examined the effect of TRT on cardiovascular outcomes by comparing incidents of heart attack, stroke, and all - cause mortality among different sub-populations of treated and untreated patients.

The treatment group saw a 6.6 percent decrease in aortic inflammation, while the placebo group saw a 12 percent increase, meaning the drug is responsible for a 19 percent improvement relative to untreated patients.

The results of the trial, which compared a combination of checkpoint inhibitors ipilimumab and nivolumab against ipilimumab alone in previously untreated patients, were presented today at the 2015 Annual Meeting of the American Association for Cancer Research and have been simultaneously published in the New England Journal of Medicine.

«It's very encouraging to see that pattern reflected in this trial with previously untreated patients.»

A 1975 paper in the Journal of the American Medical Association, for instance, showed that people infected with a common cold virus called the rhinovirus shed more virus particles if they were treated with aspirin than untreated patients.

On the other hand, L90M and K103N can also multiply in the absence of drugs, which means that untreated patients can propagate these two types of resistance.

The study's main flaw, says Jonathan Cooper, a neuroscientist at King's College London in the United Kingdom, is the untreated patients used for comparison.

On measures of motor function, language, and seizure frequency, however, the children appeared to deteriorate more slowly compared with untreated patients, dropping about two points less on a nine - point scale than controls.

Dr Muraro explained the number of years this treatment prevented symptoms from worsening is far greater than would be expected in untreated patients with severe forms of relapsing MS.

Individuals treated with emicizumab experienced 87 % fewer bleeds compared to untreated patients and 79 % fewer bleeds compared to patients treated with bypassing agents.

A case - control study of metabolic therapy for fibromyalgia: long - term follow - up comparison of treated and untreated patients (abstract).