In a
birth cohort study, risk of psychosis in adulthood was raised
by a factor of 4 if the mother, during pregnancy, reported that a baby was
unwanted.49 Separation from
parents in early life has been found to predict an increased risk of psychosis in genetically vulnerable children, 50,51 and the association between immigrant status and severe mental illness may be at least partially explained
by the high rates of early separation in migrant populations.52 Adolescents at high genetic risk of psychosis have also been found to be at increased risk of psychosis in later life if they report adverse relationships with their
parents.53