Sentences with phrase «up immune cell responses»

Inflammation is a known feature of heart failure, and it is associated with high levels of inflammatory proteins called cytokines — including one called tumor necrosis factor alpha or TNF - a — that ramp up immune cell responses.

Not exact matches

In December, SQZ partnered with global pharma firm and cancer treatment leader F. Hoffmann - La Roche in a deal that could be worth $ 500 million or more — a large undisclosed upfront payment, and additional sums when SQZ meets certain milestones — to speed up the development of its technology specifically to inject a person's immune cells with a protein to activate a «killer T» cell response to fight off cancer.

The tattooing process works by injecting ink into the skin, which stimulates an immune response in which cells called «macrophages» move into the area and «eat up» the ink.

Avoid foods and drinks with lots of sugar as sugar can interfere with immune response (white blood cells) for up to 6 hours after consumption.

A drug used to stop immune cells from gobbling up transplanted organs and bone marrow has been caught boosting the immune response to a virus in mice and monkeys.

«While transient disruption of this pathway may have therapeutic benefit because it temporarily «revs up» the immune response, permanent loss of PD - 1 signals seems to result in a «flame out» where T cells can't sustain higher level activation and become more dysfunctional,» Wherry says.

CANTOS grew out of years of ups and downs in the heart disease field, as scientists tried to trace the role of inflammation, a complex cascade of immune signals and various white blood cells that occurs in response to wounds, infections, and more.

In this study, we examined the effectiveness of a vaccination targeting tumors that produced IL - 15 and its cell surface receptor called IL - 15R - alpha -LRB--RRB- and examined their ability to up - regulate (or increase) immune responses to tumor antigens,» Morris says.

IFN - I triggers many different immune responses, but can also speed up the replacement of epithelial cells.

Several previous studies have explored whether drugs can shock cells that are infected with latent HIV to make new viruses, setting them up for the kill by the natural immune response.

Instead of stirring up powerful T cells through an injected amyloid vaccine, they used a nasal spray containing two drugs that provoke a less robust but more manageable immune response.

Up until now, efforts in generating a vaccine against TB have been mainly focused on T cells (cells from the adaptive arm of our immune response with memory capacity), with very disappointing outcomes in both pre-clinical as well as clinical trials.

The pumped - up cells are then given back to the patient as reinforcements to the body's natural anti-tumor immune response.

To trigger a vigorous immune response, antigen - presenting cells (APCs) put on display chopped - up peptides from pathogens or tumor cells.

The result indicates that T cells and HLA, which together regulate much of the body's immune response, gang up in a unique way to destroy narcoleptics» hypocretin cells, the team reports online this week in Nature Genetics.

Other immune cells, the specific killer cells, which are also known as CD8 + T cells and multiply prodigiously and mature in response to an infection, can also exhibit stress symptoms and thereby potentially end up on the NK cells» hit list.

Thanks to decades of work by Dr. Steinman and other CRI investigators, it is now known that DCs are exceptionally powerful initiators of immunity, with the ability to activate an immune response up to 100 times more potent than any other cell in the immune repertoire.

As fibrin builds up in the brain, it triggers an immune response that leads to the degradation of the nerve cells» myelin sheath, over time contributing to the progression of MS.

Immune Design is a clinical - stage biotechnology company made up of collaborative, «can do», experienced professionals passionate about leveraging the company's leading - edge technologies that target dendritic cells for a more precise immune response for the treatment of cancer and other chronic conditions.

NK cells are one of the innate immune systems «first responders» that help to control an infection while the adaptive immune responses are gearing up.

If someone has an immune response to wheat, but it does not result in celiac, they will manifest that in other ways, such as becoming Type 1 diabetic because the immune response has killed the islet cells, or their thyroid becomes inactive or cancerous... or their spleen swells up, or they manifest arthritis or rheumatic illness of some kind....

Another potential mechanism through which iodine exacerbates or induces Hashimoto's is by up - regulating Th17 cells, the immune cell subset responsible for tissue destruction in autoimmune disease, and by suppressing development of regulatory T cells, the population that invokes oral tolerance to arrest autoimmune responses (31).

«Because 70 percent of the cells that make up the body's immune system are found in the wall of the gut, what we eat also may affect the body's immune response.»