Sentences with phrase «up of amyloid»

But studying it in mice (easier to examine the brains of) that fasting or otherwise restricted food actually accelerates the process of autophagy in the brain, removing or impeding the build up of Amyloid - B.

More recently, as scientists realized that IDE was also involved in clearance of amyloid - beta, they have begun searching for ways to supercharge the enzyme to see if it could prevent the build - up of the amyloid plaques that are a hallmark of Alzheimer's disease.

One of the early signs of Alzheimer's disease is the build - up of amyloid - beta fragments in a patient's brain.

Scientists have debated for years whether the build - up of amyloid - β causes the memory loss and other symptoms of Alzheimer's.

A decade ago, these similarities prompted neuroscientist Mathias Jucker at the University of Tübingen in Germany to test whether injecting brain extracts containing misfolded amyloid - β into mice could seed an abnormal build - up of amyloid in the animals» brains.

A plaque is an accumulation of proteins that are primarily made up of Amyloid beta (A-beta), a small structure that splits off from the Amyloid Precursor Protein (APP).

Using a special imaging technique, Northwestern Medicine scientists have discovered the toxic build - up of amyloid protein is greater on the left side of the brain — the site of language processing — than on the right side in many individuals living with PPA.

«Using nanoliposomes offers an alternative way to inhibit the toxic build - up of amyloid plaques without activating an immune response in the brain.

They found that the horse tissue contained proteins that are commonly seen in the brains of people with Alzheimer's disease — such as the build - up of amyloid protein.

Not exact matches

For example, Eli Lilly & Co. (NYSE: LLY) has a phase 3 study of solanezumab under way in mild to moderate Alzheimer's disease patients that may slow disease progression by breaking up amyloid plaque buildups thought to be a major cause of the disease.

They didn't seem to make up anything of a higher order, except when they unraveled into amyloid fibers, stuck together and blocked fluid flow,» Lieberman said.

«Amyloid is one of many substances that builds up in plaques as a result of dying cells and atrophy in the brain,» he says.

Curiously, though, one strain racked up tons of brain amyloid whereas another ended up with less than usual.

An analysis of the peptide's structure in semen indicated that it hooked up with similar fragments to create amyloid fibers (clusters of protein fragments that have also been implicated in diseases such as Alzheimer's).

Up to now researchers thought that the astrocytes migrated towards the amyloid plaques and devoured them, so that reinforcing their activity could be a good remedy against development of the disease.

Recent studies in those with an inherited form of early Alzheimer's detected the presence of rogue amyloid proteins up to two decades before symptoms emerged, suggesting that we're intervening too late, when the damage is irreparable.

But Holtzman and other researchers previously demonstrated that plaques of amyloid - beta protein build up faster in the brains of APOE4 carriers (SN: 7/30/11, p. 9).

These plaques, which are believed to cause the dementia associated with the disease, are made up of tangles of amyloid beta (Aβ), a protein that is found in soluble form in healthy individuals.

Brains of patients with Alzheimer's disease clog up too, but with plaques made from a different protein called amyloid beta peptide.

Several factors have been implicated in Alzheimer's, including the build - up of an abnormal protein called beta amyloid, fibrous tangles in the brain involving abnormal forms of a protein called tau, and — most recently — an association between the disease and a gene called ApoE.

One look at an image of an Alzheimer's afflicted brain is unflinching testimony to the disease's cruelty: It destroys of up to 30 percent of a brain's mass, carving out ravines and depositing piles of molecular junk, most visibly amyloid plaque.

b - secretase acts like a pair of molecular scissors, snipping a piece off a large protein to produce b - amyloid, a smaller protein that builds up in plaques in the brains of Alzheimer's patients and is thought to kill neurons.

They also showed in mice studies and in the laboratory that NCAM2 was broken down by another protein called beta - amyloid, which is the main component of the plaques that build up in the brains of people with the disease.

That variety cropped up in a different part of the brain than the other strains, and it also produced clumps of proteins akin to the amyloid plaques found in sporadic Creutzfeldt - Jakob disease, a fatal brain disease of unknown origin that usually affects those over age 55.

Instead of stirring up powerful T cells through an injected amyloid vaccine, they used a nasal spray containing two drugs that provoke a less robust but more manageable immune response.

Researchers believe the disease progresses because of sticky clumps of beta - amyloid proteins that form and build up between neurons, eventually killing them.

Now, a new technology called Amyloid PET Imaging allows researchers to study the build - up of the toxic amyloid durinAmyloid PET Imaging allows researchers to study the build - up of the toxic amyloid durinamyloid during life.

The nerve cell death in Alzheimer s patients is linked to the build - up of plaques in their brains, which consist mostly of an insoluble protein called β - amyloid.

Plaques are the build up of sticky proteins called beta amyloid, and tangles are twisted strands of a protein called tau.

Insulin plays many roles in the brain — it is involved in memory formation, and it helps to keep synapses free of protein debris, including the tau tangles and amyloid plaques that build up in Alzheimer's, Craft says.

Just a few years ago, William Klunk and his colleagues at the University of Pittsburgh, Pennsylvania, announced that they had come up with a compound that binds selectively to amyloid, the protein from which up the characteristic Alzheimer's plaques are formed.

The amount of beta - amyloid proteins, which make up the characteristic Alzheimer's plaques, was also much lower in the brains of the mice on the low - calorie diet.

One of the main ingredients in these plaques, a peptide called beta amyloid, is created when enzymes cut up a protein called APP.

The condition is characterised by a build - up of a protein called beta - amyloid, which forms...

More important, the antibody treatment reduced levels of amyloid - β by up to half.

The new protein helps prepare one of the raw materials that builds up in amyloid plaques.

They report that their method can reduce levels of amyloid - β, the prime suspect in Alzheimer's disease, by up to 50 % in the brains of mice.

Until now, scientists haven't thought this build - up was important to the disease process because it looked different from the types of protein accumulations — such as tau, amyloid and alpha synuclein — that are clearly toxic and always found in patients with Alzheimer's, Parkinson's and some forms of dementia.

But the findings do match up with studies in mice where PPIs increased a protein called beta - amyloid in their brains, the hallmark of Alzheimer's disease.

Other studies identified additional ways to make the brain more resistant to amyloid - beta peptides that impair neuronal function as they build up in brains of those with Alzheimer's.

IT TURNS OUT THAT the sequence of amino acids that makes up the amyloid - beta protein isn't unique to humans.

In the lab, protein amyloids, like those that clog up the brains of people who died from Alzheimer's disease, are impervious to just about anything, including extreme heat and cold and powerful detergents.

A probe invented at Rice University that lights up when it binds to a misfolded amyloid beta peptide — the kind suspected of causing Alzheimer's disease — has identified a specific binding site on the protein that could facilitate better drugs to treat the disease.

But if additional studies confirm amyloid - beta's antimicrobial function — and the role of infections in causing amyloid - beta plaques to form — this model might open up new ways of thinking about Alzheimer's therapies.

Amyloid fibers are best known as the plaque that gunks up neurons in people with neurodegenerative illnesses such as Alzheimer's and Creutzfeldt - Jacob disease — the human analog of mad cow disease.

CAMBRIDGE, Mass. (June 8, 2005)-- Amyloid fibers are best known as the plaque that gunks up neurons in people with neurodegenerative illnesses such as Alzheimer's and Creutzfeldt - Jacob disease — the human analog of mad cow disease.

«There is currently a strong focus on developing treatments for Alzheimer's that aim to stop the build - up of the hallmark Alzheimer's protein, amyloid, in the brain.

This very small study suggests that one night of sleep deprivation can raise levels of the hallmark Alzheimer's protein amyloid, strengthening suggestions that sleep is important for limiting the build - up of this protein in the brain.

«Though several studies have suggested that amyloid beta builds up when we lack sleep, and previous evidence has shown sleep may give the brain a chance to clear out clumps of amyloid beta, unfortunately none have been able to confirm that sleep deprivation can cause dementia.

Using blood collected from elderly persons aged up to one hundred and demonstrating no cognitive impairment, the researchers isolated precisely those immune cells whose antibodies are able to identify toxic beta - amyloid plaques but not the amyloid precursor protein that is present throughout the human body and that presumably plays an important role in the growth of nerve cells.