Sentences with phrase «up of amyloid plaques»

More recently, as scientists realized that IDE was also involved in clearance of amyloid - beta, they have begun searching for ways to supercharge the enzyme to see if it could prevent the build - up of the amyloid plaques that are a hallmark of Alzheimer's disease.

«Using nanoliposomes offers an alternative way to inhibit the toxic build - up of amyloid plaques without activating an immune response in the brain.

Not exact matches

For example, Eli Lilly & Co. (NYSE: LLY) has a phase 3 study of solanezumab under way in mild to moderate Alzheimer's disease patients that may slow disease progression by breaking up amyloid plaque buildups thought to be a major cause of the disease.

«Amyloid is one of many substances that builds up in plaques as a result of dying cells and atrophy in the brain,» he says.

Up to now researchers thought that the astrocytes migrated towards the amyloid plaques and devoured them, so that reinforcing their activity could be a good remedy against development of the disease.

But Holtzman and other researchers previously demonstrated that plaques of amyloid - beta protein build up faster in the brains of APOE4 carriers (SN: 7/30/11, p. 9).

These plaques, which are believed to cause the dementia associated with the disease, are made up of tangles of amyloid beta (Aβ), a protein that is found in soluble form in healthy individuals.

Brains of patients with Alzheimer's disease clog up too, but with plaques made from a different protein called amyloid beta peptide.

One look at an image of an Alzheimer's afflicted brain is unflinching testimony to the disease's cruelty: It destroys of up to 30 percent of a brain's mass, carving out ravines and depositing piles of molecular junk, most visibly amyloid plaque.

b - secretase acts like a pair of molecular scissors, snipping a piece off a large protein to produce b - amyloid, a smaller protein that builds up in plaques in the brains of Alzheimer's patients and is thought to kill neurons.

They also showed in mice studies and in the laboratory that NCAM2 was broken down by another protein called beta - amyloid, which is the main component of the plaques that build up in the brains of people with the disease.

That variety cropped up in a different part of the brain than the other strains, and it also produced clumps of proteins akin to the amyloid plaques found in sporadic Creutzfeldt - Jakob disease, a fatal brain disease of unknown origin that usually affects those over age 55.

The nerve cell death in Alzheimer s patients is linked to the build - up of plaques in their brains, which consist mostly of an insoluble protein called β - amyloid.

Plaques are the build up of sticky proteins called beta amyloid, and tangles are twisted strands of a protein called tau.

Insulin plays many roles in the brain — it is involved in memory formation, and it helps to keep synapses free of protein debris, including the tau tangles and amyloid plaques that build up in Alzheimer's, Craft says.

A plaque is an accumulation of proteins that are primarily made up of Amyloid beta (A-beta), a small structure that splits off from the Amyloid Precursor Protein (APP).

Just a few years ago, William Klunk and his colleagues at the University of Pittsburgh, Pennsylvania, announced that they had come up with a compound that binds selectively to amyloid, the protein from which up the characteristic Alzheimer's plaques are formed.

The amount of beta - amyloid proteins, which make up the characteristic Alzheimer's plaques, was also much lower in the brains of the mice on the low - calorie diet.

One of the main ingredients in these plaques, a peptide called beta amyloid, is created when enzymes cut up a protein called APP.

The new protein helps prepare one of the raw materials that builds up in amyloid plaques.

But if additional studies confirm amyloid - beta's antimicrobial function — and the role of infections in causing amyloid - beta plaques to form — this model might open up new ways of thinking about Alzheimer's therapies.

Amyloid fibers are best known as the plaque that gunks up neurons in people with neurodegenerative illnesses such as Alzheimer's and Creutzfeldt - Jacob disease — the human analog of mad cow disease.

CAMBRIDGE, Mass. (June 8, 2005)-- Amyloid fibers are best known as the plaque that gunks up neurons in people with neurodegenerative illnesses such as Alzheimer's and Creutzfeldt - Jacob disease — the human analog of mad cow disease.

Using blood collected from elderly persons aged up to one hundred and demonstrating no cognitive impairment, the researchers isolated precisely those immune cells whose antibodies are able to identify toxic beta - amyloid plaques but not the amyloid precursor protein that is present throughout the human body and that presumably plays an important role in the growth of nerve cells.

Stimulating neurons in the brains with electrodes can keep them active enough to slow down the build - up of toxic neurons like amyloid plaques.

Amyloid fibers, those clumps of plaque - like proteins that clog up the brains of Alzheimer's patients, have perplexed scientists with their robust structures.

Lilly scientists had hoped that their agent, an amyloid antibody, would soak up enough of the circulating amyloid so that there weren't enough fragments around to aggregate into the toxic plaques.

The brains of individuals having Alzheimer's have clumps of amyloid plaques which are made up of aggregates of misfolded proteins.

The compound sticks to the free - floating forms of the protein amyloid, which build up into damaging plaques in the brain.

Alzheimer's disease, which is characterized by a loss in motor, psychological, and cognitive function, is attributed to the build up of beta - amyloid plaque surrounding neurons.

In a study of older adults published in Annals of Neurology, blueberries enhanced the removal of amyloid beta plaques in the brain, delaying cognitive aging by up to two and a half years.

A plaque that builds up in the brain of Alzheimer's patients called beta - amyloid plaques is believed to be one of the primary causes of Alzheimer's disease.

Studies have indicated that lithium may inhibit the build up of beta - amyloid and tau proteins, the main components of the plaques and tangles that form in the brain with Alzheimer's disease.