Sentences with phrase «up of amyloid protein»

Using a special imaging technique, Northwestern Medicine scientists have discovered the toxic build - up of amyloid protein is greater on the left side of the brain — the site of language processing — than on the right side in many individuals living with PPA.

They found that the horse tissue contained proteins that are commonly seen in the brains of people with Alzheimer's disease — such as the build - up of amyloid protein.

Not exact matches

An analysis of the peptide's structure in semen indicated that it hooked up with similar fragments to create amyloid fibers (clusters of protein fragments that have also been implicated in diseases such as Alzheimer's).

Recent studies in those with an inherited form of early Alzheimer's detected the presence of rogue amyloid proteins up to two decades before symptoms emerged, suggesting that we're intervening too late, when the damage is irreparable.

But Holtzman and other researchers previously demonstrated that plaques of amyloid - beta protein build up faster in the brains of APOE4 carriers (SN: 7/30/11, p. 9).

These plaques, which are believed to cause the dementia associated with the disease, are made up of tangles of amyloid beta (Aβ), a protein that is found in soluble form in healthy individuals.

Brains of patients with Alzheimer's disease clog up too, but with plaques made from a different protein called amyloid beta peptide.

Several factors have been implicated in Alzheimer's, including the build - up of an abnormal protein called beta amyloid, fibrous tangles in the brain involving abnormal forms of a protein called tau, and — most recently — an association between the disease and a gene called ApoE.

b - secretase acts like a pair of molecular scissors, snipping a piece off a large protein to produce b - amyloid, a smaller protein that builds up in plaques in the brains of Alzheimer's patients and is thought to kill neurons.

They also showed in mice studies and in the laboratory that NCAM2 was broken down by another protein called beta - amyloid, which is the main component of the plaques that build up in the brains of people with the disease.

That variety cropped up in a different part of the brain than the other strains, and it also produced clumps of proteins akin to the amyloid plaques found in sporadic Creutzfeldt - Jakob disease, a fatal brain disease of unknown origin that usually affects those over age 55.

Researchers believe the disease progresses because of sticky clumps of beta - amyloid proteins that form and build up between neurons, eventually killing them.

The nerve cell death in Alzheimer s patients is linked to the build - up of plaques in their brains, which consist mostly of an insoluble protein called β - amyloid.

Plaques are the build up of sticky proteins called beta amyloid, and tangles are twisted strands of a protein called tau.

Insulin plays many roles in the brain — it is involved in memory formation, and it helps to keep synapses free of protein debris, including the tau tangles and amyloid plaques that build up in Alzheimer's, Craft says.

A plaque is an accumulation of proteins that are primarily made up of Amyloid beta (A-beta), a small structure that splits off from the Amyloid Precursor Protein (APP).

Just a few years ago, William Klunk and his colleagues at the University of Pittsburgh, Pennsylvania, announced that they had come up with a compound that binds selectively to amyloid, the protein from which up the characteristic Alzheimer's plaques are formed.

The amount of beta - amyloid proteins, which make up the characteristic Alzheimer's plaques, was also much lower in the brains of the mice on the low - calorie diet.

One of the main ingredients in these plaques, a peptide called beta amyloid, is created when enzymes cut up a protein called APP.

The condition is characterised by a build - up of a protein called beta - amyloid, which forms...

The new protein helps prepare one of the raw materials that builds up in amyloid plaques.

Until now, scientists haven't thought this build - up was important to the disease process because it looked different from the types of protein accumulations — such as tau, amyloid and alpha synuclein — that are clearly toxic and always found in patients with Alzheimer's, Parkinson's and some forms of dementia.

But the findings do match up with studies in mice where PPIs increased a protein called beta - amyloid in their brains, the hallmark of Alzheimer's disease.

IT TURNS OUT THAT the sequence of amino acids that makes up the amyloid - beta protein isn't unique to humans.

In the lab, protein amyloids, like those that clog up the brains of people who died from Alzheimer's disease, are impervious to just about anything, including extreme heat and cold and powerful detergents.

A probe invented at Rice University that lights up when it binds to a misfolded amyloid beta peptide — the kind suspected of causing Alzheimer's disease — has identified a specific binding site on the protein that could facilitate better drugs to treat the disease.

«There is currently a strong focus on developing treatments for Alzheimer's that aim to stop the build - up of the hallmark Alzheimer's protein, amyloid, in the brain.

This very small study suggests that one night of sleep deprivation can raise levels of the hallmark Alzheimer's protein amyloid, strengthening suggestions that sleep is important for limiting the build - up of this protein in the brain.

Using blood collected from elderly persons aged up to one hundred and demonstrating no cognitive impairment, the researchers isolated precisely those immune cells whose antibodies are able to identify toxic beta - amyloid plaques but not the amyloid precursor protein that is present throughout the human body and that presumably plays an important role in the growth of nerve cells.

Related studies have elucidated how proteins that build up to abnormally high levels in the brain of Alzheimer's patients — amyloid beta, tau and alpha - synuclein — interact to disrupt brain function and promote memory loss.

It also showed that their immune cells were increasing noticeably in both size and activity, suggesting that these cells were cleaning up the high levels of amyloid proteins.

These studies revealed that loss of NEU1 activity was associated with a build - up in lysosomes of the amyloid precursor protein (APP), which they identified as a natural target of the enzyme.

Amyloid fibers, those clumps of plaque - like proteins that clog up the brains of Alzheimer's patients, have perplexed scientists with their robust structures.

This important process, called neurotransmission, is impaired by amyloid proteins, which build up to abnormally high levels in brains of Alzheimer's disease patients and are widely thought to cause the disease.

The brains of individuals having Alzheimer's have clumps of amyloid plaques which are made up of aggregates of misfolded proteins.

The compound sticks to the free - floating forms of the protein amyloid, which build up into damaging plaques in the brain.

Brain cells pick up the labeled leucine over the course of hours and it's incorporated into new copies of amyloid - beta and other proteins they make.

A 2014 study published in the Journal of the American Medical Association discovered that people with high levels of bad cholesterol and low levels of good cholesterol had a higher chance of developing a build - up of beta - amyloid proteins in their brain, which are indications of Alzheimer's disease and dementia.

Deep sleep plays an important role in memory, and research shows that missing out on rest can contribute to a build up of beta - amyloid protein in the brain, associated with the development of Alzheimer's disease.

Alzheimer's Disease involves the accumulation of abnormal protein — either amyloid beta or Tau protein which gums up the brain system.

Studies have indicated that lithium may inhibit the build up of beta - amyloid and tau proteins, the main components of the plaques and tangles that form in the brain with Alzheimer's disease.

That's the build - up of a certain protein called amyloid that happens in the livers of some Siamese cats, and it causes liver failure.