Several factors have been implicated in Alzheimer's, including the build -
up of an abnormal protein called beta amyloid, fibrous tangles in the brain involving abnormal forms of a protein called tau, and — most recently — an association between the disease and a gene called ApoE.
Not exact matches
Payne keyed in the symptoms, and the computer program suggested a handful
of potential conditions, including a rare disease called amyloidosis, in which
abnormal proteins build
up in the body, interfering with normal organ function and causing nerve damage.
Several
of the
proteins characteristic
of cancer cells seem to show
up in these nerve cells, and this is very
abnormal.
This turned out to be a normal
protein in the cells
of organisms throughout the animal kingdom — but in brains infected with scrapie and related diseases it turns
up in both a normal, soluble form and an
abnormal, insoluble form which accumulates in deposits that eventually kill the cells.
Gambetti, who was not involved in the new study, is co-author on a second NEJM paper appearing online today that shows that an assay similar to the CSF — based RT - QuIC test can pick
up very small amounts
of abnormal prion
protein in the urine
of people who have contracted a rare variant
of CJD that is transmitted by consuming contaminated meat.
It also clumped
up in the same location as
abnormal clumps
of nuclear pore
proteins NUP88 and NUP62.
• Keeping
abnormal proteins from building
up and potentially shutting down major organs (heart, liver and nervous system, to name a few) • Protecting the brain's functions
of learning and memory against neurotransmitter toxicity • Activating or increasing the activity
of proteins that promote the initial growth, maintenance and survival
of brain neurons • Enhancing the movement
of proteins, lipids and other cell parts through the cytoplasm
of cell bodies.
Deep inside the brains
of people with dementia and Lou Gehrig's disease, globs
of abnormal protein gum
up the inner workings
of brain cells — dooming them to an early death.
Alzheimer's Disease involves the accumulation
of abnormal protein — either amyloid beta or Tau
protein which gums
up the brain system.