AA is implicated in multiple cancer types, sometimes with very high mutational burdens, especially in
upper tract urothelial cancers (UTUCs).
Of 56 patients
with upper tract urothelial cancer, 75 percent tested positive using UroSEEK, including 79 percent of those with noninvasive tumors.
UroSEEK uses urine samples to seek out mutations in 11 genes or the presence of abnormal numbers of chromosomes that would indicate the presence of DNA associated with bladder cancer or
upper tract urothelial cancer (UTUC).
Inclusion Criteria: • Histologically documented metastatic or surgically unresectable urothelial carcinoma; may include primary site from ureters,
upper tract, renal pelvis, and bladder.
Research Interests: bladder cancer;
upper tract urothelial cancer; epigenetics; chromatin; histones; methylation; drug response; drug resistance; urology
I am a urologic oncologist and surgeon - scientist focused on using modern scientific tools to improve the management of urothelial cancers of the bladder and
upper tract.
Our lab is focused on understanding the effects of chromatin modifier mutations on the initiation and progression of urothelial cancers of the bladder and
upper tract.
In the case of the digestive tract, reduced risk seems more likely in
the upper tract (stomach and small intestine) than in the lower digestive tract (large intestine, including the colon).
The upper tract consists of two kidneys, which handle the biochemical processes; and two slender tubes (ureters)-- one leading from each kidney — that deliver waste - containing urine from the kidneys down to the lower tract.
X-rays or ultrasound may be used if the formation of a stone is suspected in
the upper tract.
HOW IS
THE UPPER TRACT WEST VIRGINIA ONLINE DRIVING SCHOOL DIFFERENT?