Sentences with word «upregulation»

Inhibitory effects of antagonists of growth hormone releasing hormone on experimental prostate cancers are associated with upregulation of wildtype p53 and decrease in p21 and mutant p53 proteins.

Ontological analyses showed significant upregulation of a large number of genes in the glutamate receptor family, including 3 of the 5 NMDA subunits.

Downregulation of microRNA - 448 inhibits IL - 1ß - induced cartilage degradation in human chondrocytes via upregulation of matrilin - 3.

Increased expression of JAG1, a ligand and downstream target of the Notch pathway (40), in ER - α — positive lines, as well as upregulation of HES1, HEY2, and HEYL, gave further evidence for activation of Notch signaling (Fig. 3B and C).

Citation: Chrostek E, Marialva MSP, Yamada R, O'Neill SL, Teixeira L (2014) High Anti-Viral Protection without Immune Upregulation after Interspecies Wolbachia Transfer.

Review: Microbiome - Mediated Upregulation of MicroRNA - 146a in Sporadic Alzheimer's Disease — Yuhai Zhao — Frontiers in Neurology

Interestingly, we detected upregulation of p16 and p15 in Polycomb - null skin epithelial stem cells in young mice where it is normally detected only in aged animals.

Immune upregulation has been shown to occur after transfer of Wolbachia into a new insect species [29]--[35].

In rat offspring exposed to 300 or 1,000 micrograms of FM550, the researchers found dose - dependent upregulation of multiple genes related to inflammatory and endocrine processes.

We and others have shown that the Polycomb chromatin complex represses the Ink4a / b locus in various adult stem cells and p15 / p16 upregulation during aging is linked to loss of Polycomb repression.

Thus, BIM upregulation and protein expression should predict a response to therapy and synergy of the two drugs, he says.

Although B - and T - cell development were normal, CD4 (+) T cells lacking Emk exhibited a marked upregulation of the memory marker CD44 / pgp -1 and produced more gamma interferon and interleukin - 4 on stimulation through the T - cell receptor in vitro.

Notably, they observed that MITF expression correlates with CDK2 upregulation in patients; thus, dinaciclib would warrant consideration for treatment of patients unresponsive to BRAF ‐ MEK and / or Hsp90 inhibitors and / or harboring MITF amplification / overexpression.

Gerard's lab also sees PD - L1 upregulation by MYC, but intriguingly, how this happens varies depending on cancer type: when MYC is switched on in pancreatic cancer models, PD - L1 is upregulated on the tumour cells themselves, whereas in a non-small cell lung cancer model, it is switched on solely in the macrophages that flood the tumour, despite MYC being activated only in the tumour cells.

These experiments show that mechanically induced Twist upregulation in stomodeal cells is necessary for subsequent midgut differentiation.

The Horch lab previously correlated upregulation of sema2a — the gene that codes for a diffusible semaphorin protein in invertebrates — with this compensatory growth.

The delayed and gradual upregulation of MHC antigens contributed to the immune privilege of these cells in the allogenic setting.

The generalized upregulation of macrophage and immunity - related genes observed in the MPS I arteries indicate that inflammation may play a prominent role in the pathogenesis of MPS I cardiovascular disease.

Although LPS causes CCR7 upregulation on splenic DCs and promotes their movement to the T zone (De Becker et al., 2000; De Trez et al., 2005; Seul et al., 2012) we found that LPS - mediated repositioning happened more slowly and with a more uniform distribution of DCs through the T zone than occurred following SRBC immunization.

Since the ubiquitin - proteasome system (UPS) is another prominent mechanism for recycling of accumulated proteins, the observed upregulation of proteasomal genes may indicate diversion of protein catabolism towards the UPS.

It's best to «pulse» the treatments because your body can't sustain upregulation for very long.

It also tends to act in the body's production of IL - 10 if it is taken during infection, downregulating the levels of other cytokines and necessary, but if taken early in the disease process, it inhibits viral upregulation of IL - 10 and increases antiviral cytokine production and activity.»

In the absence of the natural upregulation and downregulation of the TSH, the feedback mechanism regulating thyroid hormone levels may become inefficient with disuse.

Because the further improvement in muscle glucose transport in the combined group was not associated with additional upregulation of GLUT - 4 protein or a further reduction in oxidative stress, the mechanism for this interaction must be due to additional, as yet unidentified, factors.