Sentences with phrase «upstream regions of»

The distribution of Alu repeats in 5» upstream regions of housekeeping (Hkg) and tissue specific genes (Tsg) is represented in terms of the number of copies and basepairs covered by Alu repeats.

Post-stagnation behaviour in the upstream regions of Ice Stream C, West Antarctica.

Here they identified the transition when the stretch of field was detected in the downstream region of the MN, whereas the plasma state diverging the MN (i.e., thrust generation by the MN) was still maintained at the upstream region of the MN.

Not exact matches

Approximately $ 1.6 billion, or roughly two - thirds, of the Company's 2018 capital upstream budget will be allocated to the Permian region.

Residents of Ewusiejo, a rural community in the Ahanta West District of the Western Region, are reeling under the negative effects of illegal mining upstream.

Data from the GIPC, which registers all the formal FDI inflows, indicates that about 90 % of it (excluding investment in the solid mineral mining and upstream oil and gas sectors) ends up in just three of Ghana's 10 regions: Greater Accra, Ashanti and Western.

Importantly, countries such as Jordan that are dependent on waterways flowing downstream to them are vulnerable to the consequences of drought and land - use change in upstream regions.

A Nature Genetics study from August 2008 found a link between Crohn's disease and a 20,000 base - pair deletion in a region upstream of a gene called IRGM, which is involved in fighting invasive bacteria.

Now, John Chaput and his colleagues at Arizona State University's Biodesign Institute have produced the first genome - wide investigation of cap - independent translation, identifying thousands of mRNA sequences that act as Translation Enhancing Elements (TEEs), which are RNA sequences upstream of the coding region that help recruit the ribosome to the translation start site.

Copy number loss upstream of RAI1 uncovers gene expression regulatory region that may impact Potocki - Lupski syndrome diagnosis.

Andy Peters and Ursula Storb show that the initiation of Ig gene transcription targets Ig gene somatic hypermutation (SHM), by duplicating the variable (V) region promoter upstream of the constant (C) region and showing that a second wave of mutations occurs over the C region.

mAb 246 - D binds to overlapping hexapeptides which identified its core epitope as qqLLGIwg (aa 591 - 598) which is located in the immunodominant region (cluster I) of gp41, just upstream from

low to moderate upstream water use or levels of water development representative of the region (note that the vast majority of rivers in Montana are influenced to some degree by water use, and these data do reflect some human modification).

We recommend targeting the guides to a region less than 200 bp upstream of TSS for best results but up to 400 bp works reasonably well.

The role of αCaMKII autophosphorylation in the establishment of alcohol addiction Alanna Easton, King's College, UK Novel age - dependent learning deficits in a mouse model of Alzheimer's disease: implications for translational research Karienn Montgomery, University of Florida, USA Microsatellite regions upstream of the vole Avpr1a gene contribute to both individual and species differences in receptor expression Zoe Donaldson, Columbia University, USA Per Genes and Addiction Stephanie Perreau - Lenz, Central Institute of Mental Health, Germany

For some of these «differentially methylated regions» (DMRs), such as the region upstream of H19, the 5» - portion of Snrpn and the 5» - UTR of U2af1 - rs1, the allelic methylation originates from the germ line and is maintained throughout development.

He identified several of them within a 300 - kb genomic region located upstream of SOX9.

We sought to define this upstream methylation boundary and investigate whether Wilms» tumors with loss of imprinting are biallelically methylated in this upstream region.

As part of this repeat region upstream of H19, we identified an evolutionarily conserved 42 bp sequence present in human, mouse and rat which is a good candidate for an H19 imprint control element.

However, the methylation status of this upstream region has not yet been investigated in Wilms» tumors, and the upstream boundary of the potential paternal methylation imprint of the H19 gene has yet to be defined.

We constructed a targeting vector by deleting a ~ 2.6 kb region containing exons 1 and 2 and ~ 1 kb of the sequence upstream of exon1 and used the vector to generate the knockout mouse.

Wilms» tumors with loss of imprinting showed varying degrees of biallelic methylation in the H19 upstream repeat region also affecting one of the 42 bp elements which leads us to suggest that pathological methylation in this region may be the epigenetic error that initiates H19 silencing.

An imprinting mark region characterized by paternal allele specific methylation has been suggested to reside in a GC - rich region of 400 bp direct repeats starting at -2 kb relative to the H19 transcription start and extending upstream.

Noncoding transcripts originating upstream of the immunoglobulin constant region (I transcripts) are required to direct activation - induced deaminase to initiate class switching in B cells.

The shortest genomic region capable of rescuing forward and backward locomotion defects in unc - 7 mutants encompassed the coding region of unc - 7 and 1 kb of promoter sequence upstream of exon 2 (unc - 7 min; Figure 3B).

Conserved regions include the IR1 latency promoter (Wp), and one zone upstream of and two within BWRF1.IR1 is heterogeneous in 70 % of strains, and this heterogeneity arises from sequence exchange between strains as well as spontaneous mutation, with inter-strain recombination more common in tumour - derived viruses.

Derivatives of this basic construct included removal of the alternative exon 4 by deleting an Nhe I / Apa I fragment (nucleotides 12,259 — 12,543; Figure 3D); replacement of the genomic region covering exons 2 — 6 with the corresponding cDNA sequence (Sal I to Nco I; nucleotides 14,412 — 11,736; Figure 3E) plus additional upstream sequence to allow for recombination with F56B12 (to the Xho I site at nucleotide 15,574); and introduction of a Met to Leu mutation (M121L, ATG to CTG) by PCR amplification with primers that included the sequence change (nucleotides 11,968 — 11,970; Figure 3F).

The latest BBM Beta brought it with it several new features including the all new BBM Sticker Club, BlackBerry OS 10.3.2.2639 began rolling out to multiple regions and devices, John Chen will be speaking at Code / Mobile in October, and there was a another edition of the BerryFlow Upstream Podcast.

Their observations were that the region of lightly grounded ice at the glacier terminus is extending upstream, and the changes inland are consistent with the effects of a prolonged disturbance to the ice flow, such as the effects of ocean - driven melting.

Such deals, notes Hesse, sprang from lower oil prices and production revenues, plus the inability of many upstream players to bear the burden of development costs, especially in geographically challenging regions; and the desire to fund development costs in one project exiting, in whole or in part, into another project.

Among adult offspring of animals that had received relatively low levels of maternal care, we identified several hypermethylated RDme and hyperacetylated RDac upstream of the 5 ′ NR3C1 exon variants as well as in intronic regions, where transcription was also detected.

Allelic variation in this transporter's gene expression, regulated by a 43 bp indel in the upstream region termed 5 - HTTLPR, was initially associated with anxiety - related traits (23) and has since been investigated in many fields of serotonin - related human genetics (24).

RESULTS: Transcription of the MAOA gene in rhesus monkeys is modulated by an orthologous polymorphism (rhMAOA - LPR) in its upstream regulatory region.