Sentences with phrase «upstream regulators of»

Frank Mercurio and Anjana Rao report the cloning of the IκB kinases IKK - 1 and IKK - 2, the essential upstream regulators of the transcription factor NFκB.

Researchers also found that levels of cAMP and pCREB, possible upstream regulators of some circadian genes, were correlated with locomotor activity.

The results also established a hierarchy within the key pluripotency factors such that Klf4 serves as an upstream regulator of feed - forward circuits involving Oct4, Sox2, Nanog and Myc.

Not exact matches

Since the three main Westminster political parties all endorse the conclusions of Sir Ian Wood's recent review on how to maximise the economic recovery of oil and gas from the UK Continental Shelf (Search for UKCS Maximising Recovery Review Final Report, here), and its tacit underlying fiscal premises (namely that there is a need for a simplified fiscal regime to incentivise investment and drilling activity, as well as to ease the burden upon the new regulator of the upstream sector), it does not take the gift of prophecy to appreciate that the ultimate outcome of this subsequent review on the shape of the UK fiscal regime seems foreordained; namely, a return to the situation that prevailed before the introduction of SC, whereby the only levy on income from oil and gas fields is to be Corporation Income Tax at the standard rate levied on the likes of Starbucks and Amazon.

«A beautiful aspect of our findings is that we don't need an upstream regulator for AP2 - G.

The sequences of these enhancers were enriched for many of the same transcription factor (TF) binding motifs; the authors could propose upstream regulators for about half of the enhancer modules they observed.

Inactivating mutations in either p53 or in some of its upstream regulators, notably ATM and p19ARF, are common in human cancers.

We conclude that p21 plays a significant role in tumor suppression, which is more important than that of Bax but weaker than that of p53 or its upstream regulators ATM and p19ARF.

Western blot analysis showed that phosphoinositide - dependent protein kinase 1, the upstream kinase that phosphorylates Akt, and several phosphatases (phosphatase and tensin homolog deleted on chromosome 10, protein phosphatase 1, and protein phosphatase 2A), known as negative regulators of the PI3K / Akt signaling pathway, were unchanged upon VPA treatment (Supplemental Fig. 4E), indicating that VPA might act on Akt directly.