Sentences with phrase «uptake of»

When they caused FATP4 to be expressed in cells that do not normally make this protein, these cells increased their uptake of fatty acids in a manner that resembled that of normal cells.

CAMBRIDGE, Mass. (Sept. 23, 1999)-- Scientists at the Whitehead Institute for Biomedical Research and Millennium Pharmaceuticals, Inc. have identified a protein in the small intestine that plays a key role in the uptake of dietary fat into the body.

In conclusion, the data presented here collectively suggest that recent decreases in western Arctic Ocean Ωa can be predominantly attributed to recent melting of multiyear sea ice and the associated seawater freshening and uptake of atmospheric CO2; biogeochemical processes exert an additional influence.

9:45 — 10:15 Filippo Mancia (Columbia Uni) The molecular mechanisms underlying cellular uptake of vitamin A

They also suggest that the documented 30 % increase in global primary productivity over the 20th century has likely enhanced uptake of atmospheric mercury, thereby practically offsetting increasing mercury emissions.

How do communities in the nutrient - poor, so - called oligotrophic open ocean react, if the seawater gradually acidifies due to the uptake of human - induced carbon dioxide (CO2)?

Several factors like surface charge and particle size can contribute to the selective binding and uptake of nanomaterials [13], [14].

Global temperature in 2100 would be close to 1 °C in the 500 GtC scenario, and it is less than 1 °C if 100 GtC uptake of carbon by the biosphere and soil is achieved via improved agricultural and forestry practices (Fig. 9).

They suspected that this transporter may play a role in uptake of fat, and this led to the study reported this week.

To understand if leaf uptake of atmospheric mercury is important on the global scale, Martin Jiskra and Jeroen Sonke, from the Géosciences Environnement Toulouse laboratory, teamed up with scientists who monitor atmospheric mercury and CO2 levels across our planet.

Cooling by a few tenths of a degree in Fig. 9 is a result mainly of the 100 GtC biospheric uptake of CO2 during 2030 — 2080.

Binding and uptake of isolated [3H] TRLs (50 μg / ml) from control ASO - and ApoC - III ASO — treated Ldlr — / — Ndst1fl / fl Alb - Cre + mice in primary hepatocytes isolated from Ndst1fl / fl Alb - Cre + and Ldlr — / — Lrp1fl / fl Alb - Cre — mice after a 4 - hour incubation at 37 °C (n = 3 / condition).

The seasonal fluctuation is caused by variations in uptake of carbon dioxide by land plants.

Additionally, as this research uses proton nuclei within the probes, instead of heteronuceli such as carbon or nitrogen, any currently installed hospital MRI scanner can record these measurements which may ensure a rapid uptake of this technique.

SLC6A14 mediates Na + / Cl − - coupled concentrative uptake of a broad - spectrum of amino acids.

For over a century, distinctions between types of cells relied on how they appeared under a microscope: their shapes, sizes, locations and their uptake of staining dyes.

Models do a fairly poor job currently and this is a very important region for the uptake of heat and carbon from human activities.

«Warming of the oceans and increased uptake of CO2 is of increasing concern for the marine environment.

«That issue starts at the cellular - molecular level, with the actual testing and the understanding that biologists have of the pathology of colorectal cancer and diagnosis of colorectal cancer, all the way to the community uptake of that screening.»

The former causes uptake of viral genomes by host cells and leads to subsequent gene expression (25).

They found that female amniotic cells had significantly higher uptake of nanoparticles (quantum dots) than male cells.

«This amount is in the order of magnitude of the annual net uptake of carbon by the biosphere of the oceans,» notes Markus Reichstein.

With the aid of global Earth observations and data - driven models, the researchers show that on average, extreme events prevent the uptake of around 3 petagrams carbon per year by the vegetation.

The biological differences between male and female cells may influence their uptake of nanoparticles, which have been much discussed as specific delivery vehicles for medicines.

The treatment of uncertainty in the ocean's uptake of heat varies, from assuming a fixed value for a model's ocean diffusivity (Andronova and Schlesinger, 2001) to trying to allow for a wide range of ocean mixing parameters (Knutti et al., 2002, 2003) or systematically varying the ocean's effective diffusivity (e.g., Forest et al., 2002, 2006; Frame et al., 2005).

The oceanic uptake of anthropogenic CO2 leads to a gradual acidification of the ocean.

Meanwhile, the average price of a diabetes drug prescription increased from $ 56 in 2001 to $ 76 in 2007, due in large part to the rapid uptake of newly available oral medications, increasingly prescribed as alternatives to injectable insulin.

Oceanic uptake of anthropogenic carbon dioxide (CO2) causes pronounced shifts in marine carbonate chemistry and a decrease in seawater pH. Increasing evidence indicates that these changes — summarized by the term ocean acidification (OA)-- can significantly affect marine food webs and biogeochemical cycles.

The proliferation in gut bacteria of these markers would require first the uptake of the functional resistance gene by a gut bacterium, and then a selective advantage for that bacterium to survive and multiply.

We thus propose a molecular hypothesis — termed the GL - Lect hypothesis — on how GlycoLipids and Lectins drive the formation of compositional nanoenvrionments from which the endocytic uptake of glycosylated cargo proteins is operated via clathrin - independent carriers.

Dermal uptake of tetrabromobisphenol A TBBPA by female Wistar Han rat and human skin.

«We have to consider there are two sides of the coin: On the one hand, the uptake of carbon dioxide moderates climate change but, on the other hand, it affects life in the ocean — with consequences for economy and society.»

GYS2 encodes the rate - limiting enzyme in the synthesis of glycogen in adipose tissue, which permits continued uptake of glucose into cells (32).

Nanotechnology has the potential to satisfy these requirements if some of its intrinsic shortcomings can be solved: rapid uptake of nanocarriers by RES and the toxicity as a result, and drug release outside the tumor, especially the early burst release when the fast drug release is coupled with high blood... more»

Analyzing the ratios between two Strontium isotopes, 87Sr and 86Sr, researchers can determine differences from place to place on the landscape so uptake of Strontium over a wide area can be distinguished from uptake over a small area.

A research team working with mice has discovered that blood vessels and muscles in the heart can regulate the uptake of fatty acids from our diet, and has worked out how they do this.

This has led to an uptake of 80 % of test - positive individuals reaching GMI's Center for Personalized Genetic Healthcare, and an effective strategy for identifying the majority of adult - onset heritable colon cancer (Lynch syndrome).

Apart from the various biomedical applications of nanomaterials, especially in cancer therapy, cellular uptake of nanoparticles is a key factor in recent years for efficient drug delivery applications.

Changing living conditions caused by climate change or ocean acidification — the decrease of ocean pH due to the uptake of human - induced carbon dioxide from the atmosphere — pose serious threats to marine organisms.

Uptake of D - aspartate and L - glutamate in excitatory axon terminals in hippocampus: autoradiographic and biochemical comparison with gamma - aminobutyrate and other amino acids in normal rats and in rats with lesions

Taxt T, Storm - Mathisen J (1984) Uptake of D - aspartate and L - glutamate in excitatory axon terminals in hippocampus: autoradiographic and biochemical comparison with gamma - aminobutyrate and other amino acids in normal rats and in rats with lesions Neuroscience, 11 (1), 79 - 100 PubMed 6143283

To estimate the uptake of low - density lipoproteins (LDL) in enhanced hiPS - HEP cells (from C12, C18, and C22) on Days 4, 6, and 12 post-thawing, cells were incubated for 3 or 24 hr with LDL - DyLight (1:100).

Uptake of rabies virus into epithelial cells by clathrin - mediated endocytosis depends upon actin.

TLR2 activation by proteosomes promotes uptake of particulate vaccines at mucosal surfaces.

Feely says geoengineering does not stop the uptake of carbon and acidification of the seas.

In one striking example from Afghanistan, introducing better wheat varieties alone reduced women's work burden, showing how the uptake of technology — whether seeds or machinery — can improve the quality of life.

These rising atmospheric greenhouse gas concentrations have led to an increase in global average temperatures of ~ 0.2 °C decade — 1, much of which has been absorbed by the oceans, whilst the oceanic uptake of atmospheric CO2 has led to major changes in surface ocean pH (Levitus et al., 2000, 2005; Feely et al., 2008; Hoegh - Guldberg and Bruno, 2010; Mora et al., 2013; Roemmich et al., 2015).

For instance, three scavenger receptor genes were suggested to facilitate the cellular uptake of carotenoids in the adductor muscles of orange - adductor Yesso scallop [13].

Among their findings, they confirmed that a fatty acid called oleic acid can greatly increase the uptake of dietary cholesterol.

Mechanism of Cellular Uptake of Highly Fluorescent Conjugated Polymer Nanoparticles.