Gao said the idea is exciting, as
urate levels can be raised easily and inexpensively, but it must also be done cautiously, as excessively high levels of urate can cause kidney stones and gout.
«This study provided clear evidence that, in people with early Parkinson disease, inosine treatment can safely elevate
urate levels in the blood and cerebrospinal fluid for months or years,» says Michael Schwarzschild, MD, PhD, principal investigator of the study and an MGH neurologist.
Studies by Schwarzschild's team and others have found that healthy people with naturally occurring blood levels of urate within the high normal range appear to have a reduced risk of developing Parkinson's and that the disease may progress more slowly in those with higher
urate levels.
One month after the study ended,
urate levels for all participants had returned to their original levels.
The tested dosages successfully increased blood and cerebrospinal fluid
urate levels into the target ranges, with greater increases in the moderate - elevation group.
«Inosine treatment safely elevates
urate levels in Parkinson's disease patients.»
Three participants receiving inosine did develop symptomatic kidney stones — a known consequence of high
urate levels — but two of those were not clearly urate - related stones, and all were successfully treated.
Blood tests measured
the urate level of participants.
Not exact matches
A clinical trial assessing the potential of the nutritional supplement inosine to treat Parkinson disease has found that the studied dosages successfully raised participants»
levels of the antioxidant
urate without producing serious side effects.
Primarily supported by a $ 5.6 million grant from the The Michael J. Fox Foundation for Parkinson's Research and conducted at 17 sites across the U.S., SURE - PD (Safety of
URate Elevation in Parkinson's Disease) enrolled 75 recently diagnosed Parkinson disease patients with relatively low blood
levels of
urate (less than 6 mg / dL).
Among the men with Parkinson's disease, 45 men had the highest
level of
urate and 58 men had the lowest
level of
urate.
Among the healthy men, 111 were in the group with the highest
level of
urate; 107 were in the group with the lowest
level.
«High
levels of
urate in blood associated with lower risk of Parkinson's disease.»
There was no relationship between the
level of
urate in women and whether they developed Parkinson's disease.
«The findings support more research on whether raising the
level of
urate in people with early Parkinson's may slow the disease down.»
The men with the lowest
level of
urate had
levels of less than 4.9 milligrams per deciliter.
The men who had the highest
levels of
urate were nearly 40 percent less likely to develop Parkinson's disease than those with the lowest
levels.
Serum uric acid
levels in normal pregnancy with observations on the renal excretion of
urate in pregnancy.