In vitro, Pds has been shown to produce β - glucosidase, N - acetyl - β - glucosaminidase, acid and alkaline phosphatases, esterase / esterase lipase / lipase, leucine and vailine arylamidase, naphthol -
AS - B1 - phophohydrolase, various proteinases (albumin / casein / gelatin), and
urease, while no enzymatic activity was indicated for cystine arylamidase, α - chymotrypsin, alpha / beta galactosidase, trypsin, β - glucoronidase, α - fucosidase, and α - mannosidase [11].
The byproduct of the
urease and stomach acid is toxic to epithelial cells
as are the other chemicals produced by this bacterium, leading to damage to cells, a disruption of tight junctions and inflammation.