In summary, our study demonstrates that inactivating mutations of KDM6A, which are common in
urothelial bladder carcinoma, are potentially targetable by inhibiting EZH2.
Not exact matches
Saying current noninvasive approaches for detection of
urothelial cancer are suboptimal, researchers wanted to develop a test for
bladder and UTUC cancer that would allow it to be found sooner and cheaper than current methods using cytology, which is not particularly sensitive and does not do well in detecting low - grade
bladder cancer or UTUC.
UroSEEK uses urine samples to seek out mutations in 11 genes or the presence of abnormal numbers of chromosomes that would indicate the presence of DNA associated with
bladder cancer or upper tract
urothelial cancer (UTUC).
He described the procedure to Luke and his parents: He would take some healthy cells from Luke,
urothelial cells that line the urinary tract and
bladder.
Research Interests:
bladder cancer; upper tract
urothelial cancer; epigenetics; chromatin; histones; methylation; drug response; drug resistance; urology
My lab is focused on investigating the mechanisms by which chromatin modifier gene mutations contribute to the initiation and progression of
urothelial carcinomas of the
bladder and upper tract.
I am a urologic oncologist and surgeon - scientist focused on using modern scientific tools to improve the management of
urothelial cancers of the
bladder and upper tract.
Chronic
bladder infection also leads to inflammation and can manifest
Urothelial Carcinoma.