Sentences with phrase «ursolic acid»

The combination of ursolic acid with the antioxidant, antimicrobial actions of quercetin and epicatechin makes of apple a great ally against skin lesions and acne.

Combining ursolic acid with either curcumin or resveratrol prevents cancer cells from gobbling something that they need to grow, glutamine.

According to the team lead by Dr. Adams, apple peels contain ursolic acid, while the skin of green tomatoes contain tomatidine compounds.

Adams and his colleagues examined which genes in muscle cells were turned on and off as a result of the fasting, and identified ursolic acid as a compound that would counteract these genetic changes.

Previously, Adams and his team had identified ursolic acid, which is found in apple peel, and tomatidine, which comes from green tomatoes, as small molecules that can prevent acute muscle wasting caused by starvation and inactivity.

In addition, the researchers aren't sure whether ursolic acid consumed through the diet may be enough to have the effects seen in the study.

Increased consumption in ursolic acid leads to increased strength and endurance, ultimately helping prevent obesity.

Scientists have also been using the same research strategy in discovering ursolic acid, a substance found in apple peels, which promotes muscle tissue growth.

«We also thought we might be able to use ursolic acid and tomatidine as tools to find a root cause of muscle weakness and atrophy during aging.»

Elderly mice with age - related muscle weakness and atrophy were fed diets lacking or containing either 0.27 percent ursolic acid, or 0.05 percent tomatidine for two months.

The UI study was done in collaboration with Emmyon, Inc., a UI - based biotechnology company founded by Adams, that is now working to translate ursolic acid and tomatidine into foods, supplements, and pharmaceuticals that can help preserve or recover strength and muscle mass as people grow older.

Emerging research is linking ursolic acid to the ability to turn white adipose tissue - the normal fatty deposits carried under the skin - into brown adipose tissue, a special type of fat that is burned by the body to generate heat.

Mice given the compound, called ursolic acid, became leaner and had lower blood levels of glucose, cholesterol and triglycerides.

They also fed ursolic acid to mice that were fasting and found the compound protected against muscle weakening.

«Ursolic acid ups muscle and brown fat, which boosts calorie burning,» says lead researcher Christopher Adams, MD..

When scientists added ursolic acid (found in apple skin) to the high - fat diets of mice, the mice gained less weight.

The mice were subjected to a two month diet with high concentration of ursolic acid and / or tomatidine.

† This herb also typically contains ursolic acid, which has been shown to inhibit COX - 2 in in vitro research.

Included among these phytonutrients are proanthocyanidins and anthocyanins; flavan -3-ols like catechins and epicatechins; flavonols like isorhamnetin, kaempferol, myricetin, and quercetin; and terpenoids like ursolic acid.

Those studies set the stage for testing whether ursolic acid and tomatidine might be effective in blocking the largest cause of muscle weakness and atrophy: aging.

AppleActiv contains a rich polyphenol blend with high levels of antioxidants, flavonoids, quercetin, triterpenoids, ursolic acid, vitamins and minerals.

Ursolic acid is a dietary compound found in the waxy coating of fruits such as apples as well as herbal medicines like holy basil.

Exhibiting powerful anticancer potential, ursolic acid has been effectively shown to treat the following cancers: (1)

The most promising active ingredients were then tested on model animals: ursolic acid, a waxy natural chemical found in apple peels and rosemary; curcumin, the bright yellow plant compound in turmeric; and resveratrol, a natural compound common to red grapes or berries.

To get new, additional insights on the features of kahweol as an anti-angiogenic compound, we carried out a complete set of in vitro assays previously used by us to characterize the anti-angiogenic effects of other compounds from natural sources, including aeroplysinin - 1, homocysteine, ursolic acid, puupehenone, hypericin, hyperforin and aloe - emodin, among others [11], [12], [13], [19], [20], [21].

The promising results of the study, the research into the effectiveness of ursolic acid and tomatidine compounds is to continue with human trials, ultimately resulting into new supplements for prolonging muscle growth.

Marjoram has the same two active components of oregano and a third, ursolic acid, that act to slow the rate of Alzheimer's disease, thin the blood to prevent heart attacks, and aid digestion.

Tomatidine has been shown to be tremendously more powerful than ursolic acid and it seems that it has a different manner of functioning.

It is widely believed in the scientific community that several natural substances found in common foods, like ursolic acid and tomatidine may, in the near future, be put together in food supplements or incorporated into people's diets to improve their general health.

In addition, basil has shown promise in reducing blood glucose levels as well due to its content of ursolic acid — which helps to reduce the glucose absorption that raises blood sugar levels.

Second in importance is the presence of ursolic acid, a triterpenoid with a strong anti-inflammatory activity that also helps with glucose metabolism.

The peel contains most of the fruit's metabolism - boosting fiber, as well as ursolic acid, a compound that may prevent the pounds from piling on, according to a new study from University of Iowa.

In the laboratory animal study, ursolic acid, the active compound in holy basil, combined with radiation was more effective at inducing skin cancer cell death and inhibiting new tumors from forming than radiation alone.

Primarily via stimulating protein synthesis, although some researchers are even looking for ways to activate it to prevent atrophy (eg, Dyle et al., 2014)(eg, ursolic acid & tomatidine).

Like old muscles that were treated with ursolic acid and tomatidine, old muscles lacking ATF4 were resistant to the effects of aging.

«By reducing ATF4 activity, ursolic acid and tomatidine allow skeletal muscle to recover from effects of aging,» says Adams, who also is a member of the Fraternal Order of Eagles Diabetes Research Center and the Pappajohn Biomedical Institute, and is a staff physician with the Iowa City Veterans Affairs Medical Center.

«Based on these results, ursolic acid and tomatidine appear to have a lot of potential as tools for dealing with muscle weakness and atrophy during aging,» Adams says.

In their latest study, Adams» team found that ursolic acid and tomatidine dramatically reduce age - related muscle weakness and atrophy in mice.

Adams» team investigated the molecular effects of ursolic acid and tomatidine in aged skeletal muscle.

Providing 500 mg per capsule and standardized to contain a minimum.2 % Ursolic acid, Now's Holy Basil has been shown to help inhibit COX - 2 (inflammatory enzyme); reduce the negative effects stress has on the body by supporting the adrenals; help to maintain normal blood sugar levels and protect the nervous system.