Sentences with phrase «use antibodies»

The flexibility and customizability of the new indirect EasySep ™ Release Positive Selection Kits enable researchers to use antibodies directed to virtually any targets of their choice.

Some cancer treatments use antibodies to target and destroy specific tumor cells.

The researchers hope these findings will elicit a sense of caution in future HIV clinical trials set out to use antibodies for prevention, especially in the mother - to - child setting.

Just as cells of the immune system use antibodies to recognize pathogens, researchers in this study designed antibodies to recognize a protein over-expressed by these cancer cells, namely the protein mesothelin.

The research, published in the September issue of Immunity, is part of a broad reverse - engineering effort by scientists around the world to use antibodies isolated from HIV - infected people to guide the development of a successful vaccine.

Immune checkpoint blockade therapies use antibodies to counter the defensive tactics of tumor cells.

The primary aim is to investigate the use of targeted therapy using antibodies and antibody - conjugates and remove toxic chemotherapy and radiation from the treatment to maintain high cure rates and decrease late effects.

The samples are whisked away to the laboratory, where a Spanish team headed by Felipe Gomez, from the Astrobiology Centre in Madrid, runs them through the immunoassay machine, using antibodies to latch onto the proteins that may represent a sign of life.

Researchers have made headway in understanding the H5N1 virus; they have created new vaccines and are looking into other possible treatments, such as using antibodies from survivors.

One approach uses an antibody called ipilimumab, which may block a molecule that inhibits the immune system.

«New approach could make bone marrow transplants safer: Using antibodies in place of radiation, chemotherapy.»

In earlier work, Demir Akin of Stanford University and his colleagues used antibodies and nanoparticles to attach molecules of DNA to weakened Listeria monocytogenes, which is a bacterium responsible for many cases of food poisoning.

In a study recently published in the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxic.

«In order to block tumor recurrence after radiation therapy, we used an antibody to target and inhibit these cancer stem cells,» said Dr. Xu.

In one, researchers working with mice at the Institute of Molecular and Cellular Biology in Singapore used antibodies to target proteins inside cancer cells — an impressive feat, since the antibodies were long considered too large to cross the cancer cell's outer membrane.

That is exactly what we are attempting to do, using this antibody therapy.»

Next, the researchers used antibodies recognizing Rh7 to determine its expression pattern.

CIEP and similar immunological methods «are based on detecting proteins by using antibodies that would recognize the protein by shape.

Katzelnick et al. used antibody - binding data to map structural divergence and antigenic variation among dengue viruses.

To track down the location of proteins inside human tissues, Uhlén's team of about 100 scientists breaks the problem into two parts — finding antibodies that target individual proteins and then using those antibodies to hunt for proteins inside tissues.

Using an antibody that binds and labels a specific viral protein, the researchers tracked the virus as it first infected nerves in the gut 2 or 3 days after the nasal spray and then successively appeared in the brain stem and midbrain and ultimately infected much of the rest of the brain within 10 days.

The current work, she explains, uses antibodies that were generated and characterized at CNDR previously to see if they would reduce the pathology both in cell culture and in animal models.

Since we were able to regulate the function of the PLVAP sieve using antibodies, our findings may also offer potential for restraining inappropriately strong inflammatory responses in certain inflammatory and infectious diseases,» say Auvinen and Rantakari.

Dr Hayley Luxton, lead researcher from the Molecular Diagnostics and Therapeutics Laboratory at University College London, said: «Using antibodies mounted with a toxic payload, we can exploit the fact that aggressive prostate cancer cells have more NAALADL2.

The researchers then tested each strain of the virus for susceptibility to two potent and commonly used antibodies in vaccine development experiments for HCV, HC33.4 and AR4A.

Critically, despite the detection of enhanced Zika infection in cell culture models using antibodies from macaques previously exposed to either yellow fever or dengue and then exposed to Zika, there were no signs of enhanced Zika infection seen in these macaques themselves.

Efforts are now under way to try to do this, says Harper, using antibody tests developed in several labs.

The new technique, pioneered by Wilson and fellow researchers at the Emory University School of Medicine in Atlanta, saves time by using antibodies produced by so - called B cells (white blood cells that produce and then ferry them to infection sites to battle invading germs) in response to vaccines instead of to actual infections.

Mice whose eosinophils had been incapacitated using antibodies exhibited poor defense mechanisms against tumors and soon succumbed to the disease.

To further confirm the importance of the interaction between Ly49H and m157, the research team used an antibody to block Ly49H activity in a third group of CMV - infected mice.

To investigate why checkpoint inhibitors so often stop working, Velculescu; Valsamo Anagnostou, M.D., Ph.D., instructor of oncology at the Johns Hopkins University School of Medicine; Kellie N. Smith, Ph.D., a cancer immunology research associate at the Johns Hopkins University School of Medicine; and their colleagues at the Bloomberg ~ Kimmel Institute for Cancer Immunotherapy studied tumors of four patients with non-small cell lung cancer and one patient with head and neck cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-CTLA4.

To prove this, he used antibodies to catch these attractants.

These biologic therapies use an antibody class called immunoglobulin - G (IgG) to bind to and prevent the activity of specific proteins or growth factors.

Past approaches that tried to neutralize HIV used antibodies that blocked only one receptor at a time.

M.T.: Since we are using antibody - based or mass spectrometer - based detection assays, it has been more or less invisible.

Anti-PD1 drugs use an antibody to block activation of PD1 by PD - L1, a ligand found on tumors and surrounding cells.

Red and blue were introduced with a technique called immunohistochemistry, which uses antibodies that bind to specific proteins in order to highlight certain cells or parts of cells.

It is a five - year study using an antibody called crenezumab, made by Genentech of South San Francisco, California.

Finally, Kurtis and colleagues used the antibody to develop a vaccine candidate that they gave to mice infected with a particularly lethal form of malaria.

Using an antibody test, the researchers found 40 % to 50 % fewer pyrimidine dimers in the treated skin samples.

«Strong maternal antibodies for HIV ineffective for protecting infants from HIV: Researchers caution against using antibodies to prevent transmission.»

Conventional isolation methods — ultracentrifugation, affinity purification using antibodies to surface antigens, and precipitation with polymer reagents — are not fully satisfactory for recovery efficiency, purity, and operability.

Immunotherapy is a promising strategy for the treatment of Alzheimer's that uses antibodies to stimulate the immune system to remove pieces of a protein called amyloid beta which accumulates in the brain (in deposits known as plaques) and is thought to be a major factor driving Alzheimer's neurodegenerative effects.

Using an antibody that recognizes the CD68 antigen we performed immunohistochemical analysis on these human samples and calculated the percentage of CD68 expressing cells (Figure 9).

However, despite this success, clinical trials using these antibodies caused inflammatory side effects in the brain of Alzheimer's patients, in particular amyloid - related imaging abnormalities (ARIA), which results in small bleeds and dangerous brain swelling.

The Monash BDI researchers worked in collaboration with Canadian - based company Kinexus, and used an antibody microarray to simultaneously investigate hundreds of factors involved in cell signalling that were modulated by HCV replication, including human protein kinases.

First author Dr Reza Haqshenas said the researchers then used gene silencing technology to determine whether the genes» cell factors identified using the antibody microarray were indeed important for HCV replication and therefore potential targets for anti-HCV compounds.

The analysis of doxorubicin resistance in human breast cancer cells using antibody microarrays.

We can tell which countries are investing most in research using antibodies, which companies are seeing growth or decline, which antibodies are most successful and which areas of research are seeing growth.

GigaGen focuses its activity on discovering new biological treatments by using antibodies derived from millions of cells within immune repertoires.