Sentences with phrase «use cytokine levels»
He says the finding is key, because it could pave the way to use cytokine levels to gauge the effectiveness of new therapies developed to fight Huntington's.
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Using high resolution peripheral computed tomography (XtremeCT)-- an imaging method known as virtual bone biopsy — they observed that psoriasis patients had bone loss when compared to healthy people, and this correlated with increased levels of cytokine IL - 17A in blood.
Mouse serum was collected on days 7, 14, and 28 after BMT, and the levels of cytokines were measured using ProcartaPlex Multiplex Immunoassays (eBioscience).
That suggests doctors could use high cytokine levels to help diagnose the disease in its early stages.
For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.
To analyze relationships among behavior (high vs low hostile) on the cytokine levels of each subject at each visit (social support or conflict) and each point, mixed models from SAS 9.1 (SAS Institute Inc, Cary, NC) were used with repeated measures across spouse, visit, and time of day.