Germs in biofilms
use efflux pumps that flush antibiotics out.
The TB bacteria
use efflux pumps as a strategy to remove drugs and other threats from the cell before they can work against the bacteria.
Not exact matches
To address this challenge, our research group is
using nanoparticles not only to deliver more chemotherapy drugs to the target site within cancer cells, but also to compromise the function of the
efflux pumps and thereby significantly improve safety and efficacy of cancer therapy.»
Bacteria that
use these «
efflux pumps» and that are treated with the new compound become sensitive to antibiotics they were previously resistant to.
One type of
efflux pump, which until recently had only been studied in parts, was recently modeled in its entirety and simulated
using supercomputers at Los Alamos National Laboratory.
One trick
used by some bacteria is to eject antibiotics through so - called
efflux pumps embedded in their cellular membranes.
In - vitro cell culture assays were
used to analyze the effect of MIA - 602 on
efflux pump function.