The most broadly useful methods for chemical and biochemical samples
use electrospray ionization - mass spectrometry (ESI - MS).
The new technique
uses an electrospray jet differently, to shoot ionized droplets of solvent at a sample.
Not exact matches
That approach — known as
electrospray ionization — ionizes large molecules by dissolving them in a solvent and
using an intense electric field to pull tiny charged droplets of solution from the end of a needle.
«We have demonstrated that we can
electrospray liquid precursors inside a high vacuum environment of an electron microscope and then
use electrons to facilitate useful chemical transformations,» said Fedorov.
The process involving liquid chromatography -
electrospray ionization - tandem mass spectrometry relies on a vital step called «charge derivatization» or
using a permanently charged reagent to selectively trap the estrogens and isolate them from the lipids and proteins that could interfere with estrogen detection, Schug said.
Two - dimensional polyacrylamide gel electrophoresis combined with chromatographic phosphoprotein pre-enrichment and
electrospray ionization mass spectrometry - based protein identification was
used to reveal changes of phosphoproteins in cells exposed to cyclic stretching.
Liquid chromatography mass spectrometry (LCMS) was carried out
using a Shimadzu LC - 20AD spectrometer at The Scripps Research Institute (La Jolla, CA, USA), and
electrospray ionization (ESI) mass analysis with a Thermo Scientific LTQ Orbitrap - XL spectrometer at the Salk Institute.